Suppression of RIZ in biologically unfavourable neuroblastomas

  • Authors:
    • Janos Geli
    • Nimrod Kiss
    • Per Kogner
    • Catharina Larsson
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/ijo_00000784
  • Pages: 1323-1330
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Abstract

Neuroblastoma is a paediatric solid tumor characterized by recurrent genomic abnormalities of prognostic importance. One of the most commonly observed abnormalities is deletion of the short arm of chromosome 1 and reduced expression of cancer related genes in this chromosomal arm. The long isoform of the retinoblastoma protein-interacting zink finger gene (RIZ1) is a known tumor suppressor and a candidate neuroblastoma gene located at 1p36.2. The present study was undertaken to further assess the possible involvement of RIZ in neuroblastoma development. Expression of RIZ transcripts were quantified in a panel of neuroblastoma cell lines and tumors (33 neuroblastomas and 3 ganglioneuromas). Methylation status of promoter P1 driving RIZ1 expression was quantified by bisulfite Pyrosequencing. Only low mean levels of promoter methylation (<10%) were observed in all samples. However, RIZ1 and RIZ1+2 mRNA were significantly under-expressed in biologically unfavourable tumors characterized by 1p loss (p<0.005) or MYCN amplification (p<0.005). Suppression of RIZ1 is likely to contribute to the pathogenesis of biologically unfavourable neuroblastomas. In contrast to multiple other neoplasias, RIZ1 promoter methylation is not a common event in neuroblastoma.

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November 2010
Volume 37 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Geli J, Kiss N, Kogner P and Larsson C: Suppression of RIZ in biologically unfavourable neuroblastomas. Int J Oncol 37: 1323-1330, 2010
APA
Geli, J., Kiss, N., Kogner, P., & Larsson, C. (2010). Suppression of RIZ in biologically unfavourable neuroblastomas. International Journal of Oncology, 37, 1323-1330. https://doi.org/10.3892/ijo_00000784
MLA
Geli, J., Kiss, N., Kogner, P., Larsson, C."Suppression of RIZ in biologically unfavourable neuroblastomas". International Journal of Oncology 37.5 (2010): 1323-1330.
Chicago
Geli, J., Kiss, N., Kogner, P., Larsson, C."Suppression of RIZ in biologically unfavourable neuroblastomas". International Journal of Oncology 37, no. 5 (2010): 1323-1330. https://doi.org/10.3892/ijo_00000784