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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2010 Volume 37 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2010 Volume 37 Issue 5

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Article

Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells

  • Authors:
    • Jiumao Lin
    • Youqin Chen
    • Lihui Wei
    • Xuzhen Chen
    • Wei Xu
    • Zhenfeng Hong
    • Thomas J. Sferra
    • Jun Peng

  • View Affiliations / Copyright

    Affiliations: Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350108, P.R. China
  • Pages: 1331-1338
    |
    Published online on: November 1, 2010
       https://doi.org/10.3892/ijo_00000785
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Abstract

Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. However, the molecular mechanism of the anti-cancer activity of Hedyotis Diffusa Willd remains unclear. In the present study, we investigated the cellular effects of the ethanol extract of Hedyotis Diffusa Willd (EEHDW) in the HT-29 human colon carcinoma cell line. We found that EEHDW inhibited the growth of HT-29 cells demonstrating EEHDW-induced cell morphological changes and reduced cell viability in a dose- and time-dependent manner. Furthermore, we observed that EEHDW treatment resulted in DNA fragmentation, loss of plasma membrane asymmetry, collapse of mitochondrial membrane potential, activation of caspase-9 and caspase-3, and increase of the ratio of pro-apoptotic Bax to anti-apoptotic Bcl-2, suggesting that the HT-29 cell growth inhibitory activity of EEHDW was due to mitochondrion-mediated apoptosis, which may partly explain the anti-cancer activity of Hedyotis Diffusa Willd.

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Copy and paste a formatted citation
Spandidos Publications style
Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, Sferra TJ and Peng J: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol 37: 1331-1338, 2010.
APA
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z. ... Peng, J. (2010). Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. International Journal of Oncology, 37, 1331-1338. https://doi.org/10.3892/ijo_00000785
MLA
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z., Sferra, T. J., Peng, J."Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells". International Journal of Oncology 37.5 (2010): 1331-1338.
Chicago
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z., Sferra, T. J., Peng, J."Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells". International Journal of Oncology 37, no. 5 (2010): 1331-1338. https://doi.org/10.3892/ijo_00000785
Copy and paste a formatted citation
x
Spandidos Publications style
Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, Sferra TJ and Peng J: Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. Int J Oncol 37: 1331-1338, 2010.
APA
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z. ... Peng, J. (2010). Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells. International Journal of Oncology, 37, 1331-1338. https://doi.org/10.3892/ijo_00000785
MLA
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z., Sferra, T. J., Peng, J."Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells". International Journal of Oncology 37.5 (2010): 1331-1338.
Chicago
Lin, J., Chen, Y., Wei, L., Chen, X., Xu, W., Hong, Z., Sferra, T. J., Peng, J."Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells". International Journal of Oncology 37, no. 5 (2010): 1331-1338. https://doi.org/10.3892/ijo_00000785
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