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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2010 Volume 37 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 37 Issue 6

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Article

Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence

  • Authors:
    • Jean-Louis Kraus
    • Filippo Conti
    • Sébastien Madonna
    • Aurelie Tchoghandjian
    • Christophe Beclin
  • View Affiliations / Copyright

    Affiliations: CNRS, IBDML-UMR-6216, Campus de Luminy Case 907, 13288 Marseille cedex 09, France
  • Pages: 1463-1470
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/ijo_00000798
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Abstract

N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA) represent a new class of compounds showing anti-cancer activity. At the chemical level the compounds were shown to react preferentially with thiol radicals which may lead to unfolded cysteine containing proteins and subsequent ER-stress. At the molecular level, treatment of U87 cells with this class of derivatives induced an over-expression of stress genes, including P53 and numerous P53 target genes. By generating shRNA U87 cell clones impaired in P53 expression we found that P53 mediates neither proliferation arrest of treated U87 cells nor over-expression of potential P53 targets. Moreover, we discovered that a representative HQNBA derivative (JLK1486) induces strong but transient senescence in U87 cells in a P53-independent manner. We demonstrate that, in contrast to its effect on established glioblastoma cell lines, JLK1486 induces extensive death of primary glioblastoma cells. We provide evidence that both caspase 3, and 7 activation, and cathepsin B and D activities account for at least part of this cell death.

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Copy and paste a formatted citation
Spandidos Publications style
Kraus J, Conti F, Madonna S, Tchoghandjian A and Beclin C: Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence. Int J Oncol 37: 1463-1470, 2010.
APA
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., & Beclin, C. (2010). Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence. International Journal of Oncology, 37, 1463-1470. https://doi.org/10.3892/ijo_00000798
MLA
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., Beclin, C."Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence". International Journal of Oncology 37.6 (2010): 1463-1470.
Chicago
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., Beclin, C."Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence". International Journal of Oncology 37, no. 6 (2010): 1463-1470. https://doi.org/10.3892/ijo_00000798
Copy and paste a formatted citation
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Spandidos Publications style
Kraus J, Conti F, Madonna S, Tchoghandjian A and Beclin C: Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence. Int J Oncol 37: 1463-1470, 2010.
APA
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., & Beclin, C. (2010). Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence. International Journal of Oncology, 37, 1463-1470. https://doi.org/10.3892/ijo_00000798
MLA
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., Beclin, C."Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence". International Journal of Oncology 37.6 (2010): 1463-1470.
Chicago
Kraus, J., Conti, F., Madonna, S., Tchoghandjian, A., Beclin, C."Alternative responses of primary tumor cells and glioblastoma cell lines to N,N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: Cell death versus P53-independent senescence". International Journal of Oncology 37, no. 6 (2010): 1463-1470. https://doi.org/10.3892/ijo_00000798
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