Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation

  • Authors:
    • Michael Woods
    • Rima Pant
    • Sanjay M. Mallya
  • View Affiliations

  • Published online on: December 1, 2010     https://doi.org/10.3892/ijo_00000799
  • Pages: 1471-1475
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Abstract

Maintenance of oral epithelial homeostasis requires a fine balance between cell proliferation and differentiation. However, the molecular mechanisms that couple these processes, and its deregulation in tumorigenesis are not fully understood. Cyclin D1 and its kinase partners CDK4 and CDK6 play an important role in regulating the G1-S phase of the cell cycle. Deregulation of cyclin D1 is a frequent event in oral squamous cell carcinoma. Here, we examined whether overexpression of cyclin D1, CDK4 and CDK6 can deregulate the link between oral keratinocyte proliferation and differentiation. Our results show that cyclin D1 and its kinase partners CDK4 and CDK6 enhance keratinocyte proliferation, but are not sufficient to block calcium-induced keratinocyte differentiation and suggest that deregulation of these G1-regulatory kinases alone is insufficient to uncouple the link between proliferation and differentiation.

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December 2010
Volume 37 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Woods M, Pant R and Mallya SM: Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation. Int J Oncol 37: 1471-1475, 2010
APA
Woods, M., Pant, R., & Mallya, S.M. (2010). Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation. International Journal of Oncology, 37, 1471-1475. https://doi.org/10.3892/ijo_00000799
MLA
Woods, M., Pant, R., Mallya, S. M."Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation". International Journal of Oncology 37.6 (2010): 1471-1475.
Chicago
Woods, M., Pant, R., Mallya, S. M."Cyclin D1 and cyclin D-dependent kinases enhance oral keratinocyte proliferation but do not block keratinocyte differentiation". International Journal of Oncology 37, no. 6 (2010): 1471-1475. https://doi.org/10.3892/ijo_00000799