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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2010 Volume 37 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 37 Issue 6

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Article

E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents

  • Authors:
    • Ana R. Rama
    • Jose Prados
    • Consolacion Melguizo
    • Raul Ortiz
    • Pablo J. Álvarez
    • Fernando Rodríguez-Serrano
    • Fidel Hita
    • Juan L. Ramos
    • Miguel Burgos
    • Antonia Aranega

  • View Affiliations / Copyright

    Affiliations: Institute of Biopathology and Regenerative Medicine (IBIMER), E-18071 Granada, Spain
  • Pages: 1503-1514
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/ijo_00000803
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Abstract

The E gene from ΦX174 encodes a membrane protein with a toxic domain that leads to a decrease in the tumour cell growth rate. With the aim of improving the antitumour effect on lung and colon cancer cells of the currently used chemotherapeutic drugs such as gemcitabine, carboplatin and paclitaxel, and 5-fluorouracil (5FU) plus folinic acid (FA) with irinotecan or oxaliplatine, we investigated a new combined therapy using these drugs associated to the transfection of E gene. Our results showed that E gene was able to decrease proliferation rate in A-549 and T-84 cells by inducing apoptotic the mitochondrial pathway. Significantly greater inhibition of proliferation was obtained using drugs in combination with E gene in comparison to single-agent treatments or controls. E gene combined with paclitaxel had the greatest effect on A-549 cells and combined with 5FU/FA/oxaliplatin on T-84 cells. Antitumour mechanisms of the chemotherapeutic drugs were enhanced by E gene, which itself has direct oncolytic effects inducing A-549 and T-84 apoptosis. Our in vitro results indicate that the combined therapy of E gene and cytotoxic drugs may be of potential therapeutic value as a new strategy for patients with advanced lung and colon cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Rama AR, Prados J, Melguizo C, Ortiz R, Álvarez PJ, Rodríguez-Serrano F, Hita F, Ramos JL, Burgos M, Aranega A, Aranega A, et al: E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents. Int J Oncol 37: 1503-1514, 2010.
APA
Rama, A.R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P.J., Rodríguez-Serrano, F. ... Aranega, A. (2010). E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents. International Journal of Oncology, 37, 1503-1514. https://doi.org/10.3892/ijo_00000803
MLA
Rama, A. R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P. J., Rodríguez-Serrano, F., Hita, F., Ramos, J. L., Burgos, M., Aranega, A."E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents". International Journal of Oncology 37.6 (2010): 1503-1514.
Chicago
Rama, A. R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P. J., Rodríguez-Serrano, F., Hita, F., Ramos, J. L., Burgos, M., Aranega, A."E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents". International Journal of Oncology 37, no. 6 (2010): 1503-1514. https://doi.org/10.3892/ijo_00000803
Copy and paste a formatted citation
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Spandidos Publications style
Rama AR, Prados J, Melguizo C, Ortiz R, Álvarez PJ, Rodríguez-Serrano F, Hita F, Ramos JL, Burgos M, Aranega A, Aranega A, et al: E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents. Int J Oncol 37: 1503-1514, 2010.
APA
Rama, A.R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P.J., Rodríguez-Serrano, F. ... Aranega, A. (2010). E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents. International Journal of Oncology, 37, 1503-1514. https://doi.org/10.3892/ijo_00000803
MLA
Rama, A. R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P. J., Rodríguez-Serrano, F., Hita, F., Ramos, J. L., Burgos, M., Aranega, A."E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents". International Journal of Oncology 37.6 (2010): 1503-1514.
Chicago
Rama, A. R., Prados, J., Melguizo, C., Ortiz, R., Álvarez, P. J., Rodríguez-Serrano, F., Hita, F., Ramos, J. L., Burgos, M., Aranega, A."E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents". International Journal of Oncology 37, no. 6 (2010): 1503-1514. https://doi.org/10.3892/ijo_00000803
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