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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2010 Volume 37 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2010 Volume 37 Issue 6

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Article

Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women

  • Authors:
    • Sophia Brismar Wendel
    • Tove Kaldensjö
    • Pernilla Peterson
    • Sonia Andersson
    • Kristina Broliden
    • Taha Hirbod

  • View Affiliations / Copyright

    Affiliations: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Huddinge, Sweden
  • Pages: 1565-1573
    |
    Published online on: December 1, 2010
       https://doi.org/10.3892/ijo_00000810
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Abstract

Persistent human papillomavirus (HPV) infection is a prerequisite for cervical cancer and results from bypassing the local immune response. Twenty-four volunteers underwent an ectocervical biopsy, Pap smear, tests for sexually transmitted infections including HIV and HPV genotyping. All answered a questionnaire regarding medical history. Repeat Pap smear and HPV genotyping was performed 9-26 months later. Quantitative reverse transcriptase (qRT-)PCR was used to assess expression of CD3, CD4, CD8, CD19, CD27, IL-2, IL-12, IL-4, IL-10, IL-17, HLA-DRα, TGFβ, IFNγ, PD-1, PD-L1, CTLA-4, LAG3, IgA, IgG, CCR5, CCL5/RANTES and the IL-7 receptor in the biopsies. Eleven of 24 volunteers were HPV DNA-positive at baseline. Four of 10 were infected with a persistent HPV genotype at follow-up. All target molecules were successfully amplified and quantified except for IL-4. We found no difference in mRNA expression of these molecules when comparing HPV DNA-positive and -negative women, neither when comparing persistently infected individuals or those who cleared the infection. However, mRNA expression of the B cell phenotypic marker CD19 was higher in women using hormonal contraception than those not (p<0.05). HPV infection does not evoke a local inflammatory immune response in the ectocervix measurable with qRT-PCR. Hormonal contraception may influence B cell activity in the cervix.

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Copy and paste a formatted citation
Spandidos Publications style
Brismar Wendel S, Kaldensjö T, Peterson P, Andersson S, Broliden K and Hirbod T: Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women. Int J Oncol 37: 1565-1573, 2010.
APA
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., & Hirbod, T. (2010). Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women. International Journal of Oncology, 37, 1565-1573. https://doi.org/10.3892/ijo_00000810
MLA
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., Hirbod, T."Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women". International Journal of Oncology 37.6 (2010): 1565-1573.
Chicago
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., Hirbod, T."Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women". International Journal of Oncology 37, no. 6 (2010): 1565-1573. https://doi.org/10.3892/ijo_00000810
Copy and paste a formatted citation
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Spandidos Publications style
Brismar Wendel S, Kaldensjö T, Peterson P, Andersson S, Broliden K and Hirbod T: Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women. Int J Oncol 37: 1565-1573, 2010.
APA
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., & Hirbod, T. (2010). Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women. International Journal of Oncology, 37, 1565-1573. https://doi.org/10.3892/ijo_00000810
MLA
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., Hirbod, T."Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women". International Journal of Oncology 37.6 (2010): 1565-1573.
Chicago
Brismar Wendel, S., Kaldensjö, T., Peterson, P., Andersson, S., Broliden, K., Hirbod, T."Slumbering mucosal immune response in the cervix of human papillomavirus DNA-positive and -negative women". International Journal of Oncology 37, no. 6 (2010): 1565-1573. https://doi.org/10.3892/ijo_00000810
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