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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2011 Volume 38 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2011 Volume 38 Issue 1

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Article Open Access

Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia

  • Authors:
    • Eisaku Iwanaga
    • Tomoko Nanri
    • Hiroaki Mitsuya
    • Norio Asou

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Kumamoto University Graduate School of Biosciences, Kumamoto 860-8556, Japan. sakusaku6554@fc.kuh.kumamoto-u.ac.jp
  • Pages: 25-31
    |
    Published online on: January 1, 2011
       https://doi.org/10.3892/ijo_00000820
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Abstract

TIS11D is an AU-rich element binding protein that is involved in RNA metabolism and definitive hematopoiesis. Although disruption of genes related to hematopoiesis often leads to the development of leukemia and lymphoma, the involvement of TIS11D in hematological malignancies remains to be determined. In the present study, we identified a heterozygous frameshift mutation (I373fsX91) in the carboxy-terminus of the TIS11D gene in leukemic cells from a patient with acute myeloid leukemia. Moreover, biallelic inactivation of the TIS11D gene resulting from a hemizygous frameshift mutation (G107fsX80) was identified in the Burkitt's lymphoma cell line DG75. In HeLa cells, overexpression of wild-type TIS11D protein (TIS11DWT) induced growth inhibition and an S phase checkpoint response, while the mutant protein (TIS11DI373fsX91) showed a diminished effect. Interestingly, this response was accompanied by p21 downregulation, which is frequently seen in the cellular response to ultraviolet irradiation. These data suggest that the dysregulation of TIS11D function is associated with the pathogenesis of certain types of leukemia.

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Copy and paste a formatted citation
Spandidos Publications style
Iwanaga E, Nanri T, Mitsuya H and Asou N: Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. Int J Oncol 38: 25-31, 2011.
APA
Iwanaga, E., Nanri, T., Mitsuya, H., & Asou, N. (2011). Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. International Journal of Oncology, 38, 25-31. https://doi.org/10.3892/ijo_00000820
MLA
Iwanaga, E., Nanri, T., Mitsuya, H., Asou, N."Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia". International Journal of Oncology 38.1 (2011): 25-31.
Chicago
Iwanaga, E., Nanri, T., Mitsuya, H., Asou, N."Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia". International Journal of Oncology 38, no. 1 (2011): 25-31. https://doi.org/10.3892/ijo_00000820
Copy and paste a formatted citation
x
Spandidos Publications style
Iwanaga E, Nanri T, Mitsuya H and Asou N: Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. Int J Oncol 38: 25-31, 2011.
APA
Iwanaga, E., Nanri, T., Mitsuya, H., & Asou, N. (2011). Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. International Journal of Oncology, 38, 25-31. https://doi.org/10.3892/ijo_00000820
MLA
Iwanaga, E., Nanri, T., Mitsuya, H., Asou, N."Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia". International Journal of Oncology 38.1 (2011): 25-31.
Chicago
Iwanaga, E., Nanri, T., Mitsuya, H., Asou, N."Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia". International Journal of Oncology 38, no. 1 (2011): 25-31. https://doi.org/10.3892/ijo_00000820
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