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Molecular and Clinical Oncology
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Review

Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review)

  • Authors:
    • Makoto Adachi
    • Ligy Thomas
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  • Pages: 12-14
    |
    Published online on: September 3, 2012
       https://doi.org/10.3892/mco.2012.17
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Abstract

Despite advances in surgical techniques, radiotherapy, and chemotherapy, 5‑year survival in patients with late‑stage head and neck squamous cell carcinoma (HNSCC) have not improved significantly over the past decades. HNSCC tumors are commonly associated with hypoxia, which is characterized by an acute and/or chronic decline in oxygen tension. Hypoxia is an important cancer‑aggravating microenvironmental factor that contributes to malignant behaviors such as acquisition of antiapoptotic ability by cancer cells and tumor progression, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Numerous studies have assessed tumor hypoxia and identified molecular markers that are promising therapeutic targets in HNSCC cases. Moreover, investigators have suggested a number of molecular strategies to target cell processes critical to hypoxia development in HNSCC patients via the direct or indirect regulation of hypoxia‑inducible factor-1α expression in cancer cells. In this review, we described recent advances in the identification and development of molecular-targeted therapy targeting hypoxia in HNSCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Adachi M and Thomas L: Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review). Mol Clin Oncol 1: 12-14, 2013.
APA
Adachi, M., & Thomas, L. (2013). Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review). Molecular and Clinical Oncology, 1, 12-14. https://doi.org/10.3892/mco.2012.17
MLA
Adachi, M., Thomas, L."Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review)". Molecular and Clinical Oncology 1.1 (2013): 12-14.
Chicago
Adachi, M., Thomas, L."Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review)". Molecular and Clinical Oncology 1, no. 1 (2013): 12-14. https://doi.org/10.3892/mco.2012.17
Copy and paste a formatted citation
x
Spandidos Publications style
Adachi M and Thomas L: Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review). Mol Clin Oncol 1: 12-14, 2013.
APA
Adachi, M., & Thomas, L. (2013). Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review). Molecular and Clinical Oncology, 1, 12-14. https://doi.org/10.3892/mco.2012.17
MLA
Adachi, M., Thomas, L."Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review)". Molecular and Clinical Oncology 1.1 (2013): 12-14.
Chicago
Adachi, M., Thomas, L."Molecular-targeted therapy hypoxia in head and neck squamous cell carcinoma patients (Review)". Molecular and Clinical Oncology 1, no. 1 (2013): 12-14. https://doi.org/10.3892/mco.2012.17
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