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Article

Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia

  • Authors:
    • Izumi Inoue
    • Jun Kato
    • Noriko Yoshimura
    • Yoshimasa Maeda
    • Kosaku Moribata
    • Naoki Shingaki
    • Hisanobu Deguchi
    • Shotaro Enomoto
    • Takao Maekita
    • Kazuki Ueda
    • Mikitaka Iguchi
    • Hideyuki Tamai
    • Mitsuhiro Fujishiro
    • Nobutake Yamamichi
    • Tatsuya Takeshita
    • Masao Ichinose
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan, Department of Joint Disease Research, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Public Health, School of Medicine, Wakayama Medical University, Wakayama 641-0012, Japan
  • Pages: 75-82
    |
    Published online on: September 11, 2012
       https://doi.org/10.3892/mco.2012.22
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Abstract

In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the recurrence of colorectal neoplasia was prospectively investigated. The stage of H. pylori-associated chronic gastritis in each subject was evaluated using a combination of two serum tests: H. pylori antibody and pepsinogen. In the present cohort, colorectal neoplasia recurred at a rate of 15,296/100,000 person-years during the study period. After adjusting for the confounding factors, chronic atrophic gastritis (CAG) was identified as an independent risk factor [adjusted hazard ratio (HR), 2.72; 95% confidence interval, 1.33-5.57], while H. pylori-infected non-atrophic gastritis was not identified as an independent risk factor for recurrent colorectal neoplasia. Colorectal neoplasia recurred earlier and was significantly more frequent in patients with CAG (22,573/100,000 person-years) compared to patients without CAG (11,089/100,000 person-years; P=0.029, log‑rank test). Patients with more extensive CAG showed a higher risk of recurrence. These results demonstrated a significant elevation of the risk of recurrent colorectal neoplasia with the establishment and progression of CAG, indicating the involvement of H. pylori infection in the development of colorectal neoplasia. The two serum tests were useful clinical markers for non-invasively evaluating the risk of each individual for recurrent colorectal neoplasia subsequent to endoscopic resection.
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Copy and paste a formatted citation
Spandidos Publications style
Inoue I, Kato J, Yoshimura N, Maeda Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Maekita T, Ueda K, Ueda K, et al: Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia. Mol Clin Oncol 1: 75-82, 2013.
APA
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N. ... Ichinose, M. (2013). Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia. Molecular and Clinical Oncology, 1, 75-82. https://doi.org/10.3892/mco.2012.22
MLA
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N., Deguchi, H., Enomoto, S., Maekita, T., Ueda, K., Iguchi, M., Tamai, H., Fujishiro, M., Yamamichi, N., Takeshita, T., Ichinose, M."Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia". Molecular and Clinical Oncology 1.1 (2013): 75-82.
Chicago
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N., Deguchi, H., Enomoto, S., Maekita, T., Ueda, K., Iguchi, M., Tamai, H., Fujishiro, M., Yamamichi, N., Takeshita, T., Ichinose, M."Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia". Molecular and Clinical Oncology 1, no. 1 (2013): 75-82. https://doi.org/10.3892/mco.2012.22
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue I, Kato J, Yoshimura N, Maeda Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Maekita T, Ueda K, Ueda K, et al: Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia. Mol Clin Oncol 1: 75-82, 2013.
APA
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N. ... Ichinose, M. (2013). Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia. Molecular and Clinical Oncology, 1, 75-82. https://doi.org/10.3892/mco.2012.22
MLA
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N., Deguchi, H., Enomoto, S., Maekita, T., Ueda, K., Iguchi, M., Tamai, H., Fujishiro, M., Yamamichi, N., Takeshita, T., Ichinose, M."Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia". Molecular and Clinical Oncology 1.1 (2013): 75-82.
Chicago
Inoue, I., Kato, J., Yoshimura, N., Maeda, Y., Moribata, K., Shingaki, N., Deguchi, H., Enomoto, S., Maekita, T., Ueda, K., Iguchi, M., Tamai, H., Fujishiro, M., Yamamichi, N., Takeshita, T., Ichinose, M."Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia". Molecular and Clinical Oncology 1, no. 1 (2013): 75-82. https://doi.org/10.3892/mco.2012.22
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