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Molecular and Clinical Oncology
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Article

Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma

  • Authors:
    • Daisuke Toiyama
    • Natsuki Takaha
    • Masahide Shinnoh
    • Takashi Ueda
    • Yasunori Kimura
    • Terukazu Nakamura
    • Fumiya Hongo
    • Kazuya Mikami
    • Kazumi Kamoi
    • Akihiro Kawauchi
    • Tsuneharu Miki
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan, Department of Translational Cancer Drug Development, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto 602-8566, Japan
  • Pages: 69-74
    |
    Published online on: October 15, 2012
       https://doi.org/10.3892/mco.2012.35
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Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is endogenously expressed in immune cells and contributes to immunosurveillance for cancer. TRAIL induces apoptosis preferentially in various cancer cells, including renal cell carcinoma (RCC) cells. In this study, the serum TRAIL level was examined using an enzyme-linked immunosorbent assay in 52 healthy controls and in 84 RCC patients prior to surgery and its significance as a biomarker was evaluated. The median serum TRAIL level was lower in RCC patients compared to the healthy controls (55.9 vs. 103.1 pg/ml; P=0.019). RCC with lymph node metastasis (N1-2), distant metastasis (M1), stage III-IV, or microscopic venous invasion was associated with decreased serum TRAIL levels (P=0.032, 0.067, 0.020 and 0.011). When comparing serum TRAIL levels in the same RCC patients prior and subsequent to surgery (n=11), the levels were significantly higher after surgery (P=0.031). The cause‑specific survival rate was significantly higher in RCC patients with high serum TRAIL levels compared to those with low serum TRAIL levels (P=0.0451). TRAIL was estimated to contribute 64 and 13% of the lymphocyte-mediated cytotoxicity against human RCC ACHN and Caki-1 cells, respectively. These data suggest that the serum TRAIL level may be useful as a prognostic biomarker in RCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Toiyama D, Takaha N, Shinnoh M, Ueda T, Kimura Y, Nakamura T, Hongo F, Mikami K, Kamoi K, Kawauchi A, Kawauchi A, et al: Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma. Mol Clin Oncol 1: 69-74, 2013.
APA
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T. ... Miki, T. (2013). Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma. Molecular and Clinical Oncology, 1, 69-74. https://doi.org/10.3892/mco.2012.35
MLA
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T., Hongo, F., Mikami, K., Kamoi, K., Kawauchi, A., Miki, T."Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma". Molecular and Clinical Oncology 1.1 (2013): 69-74.
Chicago
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T., Hongo, F., Mikami, K., Kamoi, K., Kawauchi, A., Miki, T."Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma". Molecular and Clinical Oncology 1, no. 1 (2013): 69-74. https://doi.org/10.3892/mco.2012.35
Copy and paste a formatted citation
x
Spandidos Publications style
Toiyama D, Takaha N, Shinnoh M, Ueda T, Kimura Y, Nakamura T, Hongo F, Mikami K, Kamoi K, Kawauchi A, Kawauchi A, et al: Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma. Mol Clin Oncol 1: 69-74, 2013.
APA
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T. ... Miki, T. (2013). Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma. Molecular and Clinical Oncology, 1, 69-74. https://doi.org/10.3892/mco.2012.35
MLA
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T., Hongo, F., Mikami, K., Kamoi, K., Kawauchi, A., Miki, T."Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma". Molecular and Clinical Oncology 1.1 (2013): 69-74.
Chicago
Toiyama, D., Takaha, N., Shinnoh, M., Ueda, T., Kimura, Y., Nakamura, T., Hongo, F., Mikami, K., Kamoi, K., Kawauchi, A., Miki, T."Significance of serum tumor necrosis factor-related apoptosis-inducing ligand as a prognostic biomarker for renal cell carcinoma". Molecular and Clinical Oncology 1, no. 1 (2013): 69-74. https://doi.org/10.3892/mco.2012.35
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