Histological profile and age at diagnosis of breast and ovarian tumors: A register-based study in Espirito Santo, Brazil

De Vargas Wolfgramm,Eldamária; Biancardi Gavioli,Camila   Fátima; Entringer,Mayara   Lemos; Alves,Lyvia  Neves Rebello; Stur,Elaine; De Castro Neto,Allan   Kardec; Da Motta,Luciene  Lage; Pereira,Fausto  Edmundo Lima; Louro,Iuri  Drumond

doi:10.3892/mco.2012.38

March-April 2013 Volume 1 Issue 2

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March-April 2013 Volume 1 Issue 2

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Article

Histological profile and age at diagnosis of breast and ovarian tumors: A register-based study in Espirito Santo, Brazil

Authors:
- Eldamária De Vargas Wolfgramm
- Camila Fátima Biancardi Gavioli
- Mayara Lemos Entringer
- Lyvia Neves Rebello Alves
- Elaine Stur
- Allan Kardec De Castro Neto
- Luciene Lage Da Motta
- Fausto Edmundo Lima Pereira
- Iuri Drumond Louro
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Affiliations: Center of Molecular and Human Genetics, Department of Biology, Federal University of Espirito Santo, Vitória 29043-900, Espirito Santo, Brazil, Pathology Laboratory, Santa Rita de Cássia Hospital, Vitória 29043-260, Espirito Santo, Brazil , Pathology Laboratory, Santa Casa de Misericórdia de Vitoria Hospital, Vitória 29018-180, Espirito Santo, Brazil
Pages: 353-358
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Published online on: November 5, 2012

https://doi.org/10.3892/mco.2012.38
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Abstract

Breast and ovarian cancers are important public health problems in Brazil. However, in various locations in the Brazilian territory these types of cancer remain poorly characterized. Therefore, this study aimed to compare data collected from the Pathology Services of two Oncology Reference Hospitals in Espirito Santo state (Brazil) with the data in previous Brazilian studies. Histological type frequency and age at diagnosis of breast and ovarian tumors between 2001‑2004 and 2009‑2010 were analyzed. Tumor size, histological grade, lymph node status, hormone receptor status [estrogen (ER) and progesterone receptors (PR)] as well as HER2 and Ki-67 marker status were obtained for the cases of infiltrating ductal carcinomas of the breast during the period 2009‑2010. Categorical variables were described by their absolute and/or relative frequencies, while quantitative variables were expressed as the mean ± standard deviation and median, using 95% confidence intervals. Chi-square tests were performed to examine whether or not the studied variables differed by age at the time of diagnosis. Malignant breast tumors (1,758) and 119 malignant ovarian tumors were examined. Mean ages for malignant breast and ovarian tumors were 53.59 and 52.98 years, respectively. An increased tumor frequency in the age group of ≤35 years was observed for other malignant tumors of the breast during the period of 2009‑2010, compared to 2001‑2004. When considering only infiltrating ductal carcinomas with immunohistochemistry records available, there were 82.1% (133 cases) of ER+/PR+ tumors, 1.9% (3 cases) of ER-/PR-/HER2 3+ and 16.04% (26 cases) of ER-/PR-/HER2- tumors. The findings of this study demonstrated detailed information concerning breast and ovarian tumor behavior in the Espirito Santo state (Brazil), allowing for a precise comparison with other populations (Brazilian or international), which may be helpful in the planning of prevention and treatment strategies.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Histological profile and age at diagnosis of breast and ovarian tumors: A register-based study in Espirito Santo, Brazil

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