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Article

Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients

  • Authors:
    • Takuya Akahane
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Teikyo University School of Medicine, Tokyo 173-0003, Japan
  • Pages: 267-273
    |
    Published online on: November 22, 2012
       https://doi.org/10.3892/mco.2012.43
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Abstract

The cytoplasmic ribonuclease DICER1 is one of the key enzymes in microRNA (miRNA) processing, essential for the production of mature miRNA. The effect of DICER1 expression in tumor cells on the prognosis of patients with several cancers has been examined with controversial results in various cancer types. In particular, the clinical significance of DICER1 expression in colorectal cancer (CRC) patients has yet to be determined. The aim of this study was to evaluate the correlation between the DICER1 mRNA levels and the clinicopathological characteristics and prognostic significance in CRC patients. Tumor and normal adjacent tumor tissues from 260 patients with CRC (Dukes' stage A: 40 cases, Dukes' B: 68 cases, Dukes' C: 88 cases and Dukes' D: 64 cases) were examined. The DICER1 mRNA levels were measured using the TaqMan real‑time reverse transcription polymerase chain reaction (RT‑PCR) method. The expression levels of DICER1 mRNAs showed a significant decrease in CRC tissues as compared to normal ones (P=0.039). A statistically significant association was observed between DICER1 mRNA expression and tumor size, depth of invasion, lymph node metastasis, lymphatic invasion and Dukes' stage. In Kaplan‑Meier survival curve analysis, overall survival (OS) and disease‑free survival (DFS) rates of patients with a low DICER1 mRNA expression were significantly worse compared to patients with a high DICER1 mRNA expression (OS P<0.001; DFS P<0.001). In the Cox multivariate analysis, DICER1 mRNA expression in CRC tissues was identified as an independent prognostic factor for OS [hazard ratio (HR), 0.30; 95% confidence interval (CI), 0.13-0.64; P=0.001] and DFS (HR, 0.23; 95% CI, 0.10-0.48; P=0.001). This study demonstrated that a reduced DICER1 mRNA expression is associated with poor prognosis in CRC patients.
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1 

Gill S, Thomas RR and Goldberg RM: Review article: colorectal cancer chemotherapy. Aliment Pharmacol Ther. 18:683–692. 2003. View Article : Google Scholar

2 

Aggarwal S and Chu E: Current therapies for advanced colorectal cancer. Oncology. 19:589–595. 2005.PubMed/NCBI

3 

Caldas C and Brenton JD: Sizing up miRNAs as cancer genes. Nat Med. 11:712–714. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar

5 

Jovanovic M and Hengartner MO: miRNAs and apoptosis: RNAs to die for. Oncogene. 25:6176–6187. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Mott JL: MicroRNAs involved in tumor suppressor and oncogene pathways: implications for hepatobiliary neoplasia. Hepatology. 50:630–637. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH and Kim VN: MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23:4051–4060. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Lee Y, Ahn C, Han J, et al: The nuclear RNase III Drosha initiates microRNA processing. Nature. 6956:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Lund E, Güttinger S, Calado A, Dahlberg JE and Kutay U: Nuclear export of microRNA precursors. Science. 5654:95–98. 2004. View Article : Google Scholar

10 

Yi R, Qin Y, Macara IG and Cullen BR: Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17:3011–3016. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Hutvágner G, McLachlan J, Pasquinelli AE, Bálint E, Tuschl T and Zamore PD: A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science. 5531:834–838. 2001.PubMed/NCBI

12 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Cullen BR: Transcription and processing of human microRNA precursors. Mol Cell. 16:861–865. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Carmell MA and Hannon GJ: RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol. 11:214–218. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Cummins JM, He Y, Leary RJ, et al: The colorectal microRNAome. Proc Natl Acad Sci USA. 103:3687–3692. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ambros V, Bartel B, Bartel DP, et al: A uniform system for microRNA annotation. RNA. 9:277–279. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Karube Y, Tanaka H, Osada H, et al: Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci. 96:111–115. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Merritt WM, Lin YG, Han LY, et al: Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 359:2641–2650. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Chiosea S, Jelezcova E, Chandran U, Acquafondata M, McHale T, Sobol RW and Dhir R: Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol. 169:1812–1820. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW and Dacic S: Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 67:2345–2350. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Grelier G, Voirin N, Ay AS, et al: Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer. 101:673–683. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Stratmann J, Wang CJ, Gnosa S, Wallin A, Hinselwood D, Sun XF and Zhang H: Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. BMC Cancer. 11:3452011. View Article : Google Scholar : PubMed/NCBI

23 

Faggad A, Kasajima A, Weichert W, Stenzinger A, Elwali NE, Dietel M and Denkert C: Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer. Histopathology. 20: View Article : Google Scholar : 2012.PubMed/NCBI

24 

Faber C, Horst D, Hlubek F and Kirchner T: Overexpression of Dicer predicts poor survival in colorectal cancer. Eur J Cancer. 47:1414–1419. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Wiemer EA: The role of microRNAs in caner: no small matter. Eur J Cancer. 43:1529–1544. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Nelson P, Kiriakidou M, Sharma A, Maniataki E and Mourelatos Z: The microRNA world: small is mighty. Trends Biochem Sci. 28:534–540. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Calin GA and Croce CM: MicroRNA-cancer connection: the beginning of a new tale. Cancer Res. 66:7390–7394. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Zheng ZH, Sun XJ, Fu WN, Guan Y, Gao F, Wang Y and Sun KL: Decreased expression of DICER1 in gastric cancer. Chin Med J. 120:2099–2104. 2007.PubMed/NCBI

29 

Pampalakis G, Diamandis EP, Katsaros D and Sotiropoulou G: Down-regulation of dicer expression in ovarian cancer tissues. Clin Biochem. 43:324–327. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Papachristou DJ, Korpetinou A, Giannopoulou E, et al: Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas. Virchows Arch. 459:431–440. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Flavin RJ, Smyth PC, Finn SP, et al: Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients. Mod Pathol. 21:676–684. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Martin MG, Payton JE and Link DC: Dicer and outcomes in patients with acute myeloid leukemia (AML). Leuk. Res. 33:e1272009. View Article : Google Scholar : PubMed/NCBI

33 

Guo X, Liao Q, Chen P, et al: The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasoparyngeal carcinoma. J Cancer Res Clin Oncol. 138:49–56. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Zhu DX, Fan L, Lu RN, et al: Downregulation Dicer expression predicts poor prognosis in chronic lymphocytic leukemia. Cancer Sci. 103:875–881. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Sarasquete M, Gutierrez NC, Misiewicz-Krzeminska I, et al: Upregulation of Dicer is more frequent in monoclonal gammopathies of undetermined significance than in multiple myeloma patients and is associated with longer survival in symptomatic myeloma patients. Haematologica. 96:468–471. 2011. View Article : Google Scholar

36 

Faggad A, Budczites J, Tchemitsa O, et al: Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression. J Pathol. 220:382–391. 2010.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Akahane T: Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients. Mol Clin Oncol 1: 267-273, 2013.
APA
Akahane, T. (2013). Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients. Molecular and Clinical Oncology, 1, 267-273. https://doi.org/10.3892/mco.2012.43
MLA
Akahane, T."Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients". Molecular and Clinical Oncology 1.2 (2013): 267-273.
Chicago
Akahane, T."Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients". Molecular and Clinical Oncology 1, no. 2 (2013): 267-273. https://doi.org/10.3892/mco.2012.43
Copy and paste a formatted citation
x
Spandidos Publications style
Akahane T: Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients. Mol Clin Oncol 1: 267-273, 2013.
APA
Akahane, T. (2013). Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients. Molecular and Clinical Oncology, 1, 267-273. https://doi.org/10.3892/mco.2012.43
MLA
Akahane, T."Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients". Molecular and Clinical Oncology 1.2 (2013): 267-273.
Chicago
Akahane, T."Clinicopathological and prognostic significance of the microRNA processing enzyme DICER1 mRNA expression in colorectal cancer patients". Molecular and Clinical Oncology 1, no. 2 (2013): 267-273. https://doi.org/10.3892/mco.2012.43
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