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Molecular and Clinical Oncology
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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy

  • Authors:
    • Hong-Bo Zhang
    • Ping Lu
    • Wen-Bo Cao
    • Zhen-Hua Zhang
    • Xiang-Lei Meng
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Cell Biology, School of Medicine, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450008, P.R. China, Department of Cancer Biology, School of Medicine, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China
  • Pages: 395-399
    |
    Published online on: December 17, 2012
       https://doi.org/10.3892/mco.2012.52
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Abstract

Chinese herbs are potential sources of antitumor drugs with immunoregulatory activity and few adverse effects. In the present study, we investigated whether the Hypericum japonicum Thunb. (HJT) extract enhanced the efficacy of 5‑fluorouracil (5‑FU) treatment in murine liver tumor xenografts and reduced toxicity of chemotherapy in hepatoma H22‑bearing mice. Tumor weight and inhibition rate, thymus and spleen indices, as well as white blood cell (WBC) count were calculated. The phagocytic function of macrophages was assessed by observing peritoneal macrophages phagocytized chicken red blood cells (RBC). Body weight and toxic reactions of the chemotherapeutic and life prolongation rate were investigated in the mice. Results demonstrated that the HJT extract significantly enhanced the tumor inhibition rate of 5‑FU, improved the immune function, reduced the toxic effects and prolonged the survival time in the tumor‑bearing mice. Taken together, these results indicated that the HJT extract has a synergistic tumor‑inhibiting effect with 5‑FU, is able to reduce the toxic side effects and is likely to be safe and efficacious for use in antitumor therapy.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar

2 

Dai LC, Wang X, Yao X, Lu YL, Ping JL and He JF: Enhanced therapeutic effects of combined chemotherapeutic drugs and midkine antisense oligonucleotides for hepatocellular carcinoma. World J Gastroenterol. 13:1989–1994. 2007. View Article : Google Scholar

3 

Yu J, Liu H, Lei J, Tan W, Hu X and Zou G: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res. 21:817–822. 2007. View Article : Google Scholar

4 

Vickers A: Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Invest. 20:1069–1079. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Liu F, Wang JG, Wang SY, Li Y, Wu YP and Xi SM: Antitumor effect and mechanism of Gecko on human esophageal carcinoma cell lines in vitro and xenografted sarcoma 180 in Kunming mice. World J Gastroenterol. 14:3990–3996. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Wu SL, Sun ZJ, Yu L, Meng KW, Qin XL and Pan CE: Effect of resveratrol and in combination with 5-FU on murine liver cancer. World J Gastroenterol. 10:3048–3052. 2004.PubMed/NCBI

7 

Cao Y, Xia QH, Meng H and Zhong AP: Antitumor and synergistic effect of Chinese medicine ‘bushen huayu jiedu recipe’ and chemotherapy on transplanted animal hepatocarcinoma. World J Gastroenterol. 11:5218–5220. 2005.

8 

Dongre SH, Badami S, Natesan S and H RC: Antitumor activity of the methanol extract of Hypericum hookerianum stem against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci. 103:354–359. 2007.PubMed/NCBI

9 

Radulović N, Stankov-Jovanović V, Stojanović G, Šmelcerović A, Spiteller M and Asakawa Y: Screening of in vitro antimicrobial and antioxidant activity of nine Hypericum species from the Balkans. Food Chem. 103:15–21. 2007.

10 

Jayasuriya H, Clark AM and McChesney JD: New antimicrobial filicinic acid derivatives from Hypericum drummondii. J Nat Prod. 54:1314–1320. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Jayasuriya H, McChesney JD, Swanson SM and Pezzuto JM: Antimicrobial and cytotoxic activity of rottlerin-type compounds from Hypericum drummondii. J Nat Prod. 52:325–331. 1989. View Article : Google Scholar : PubMed/NCBI

12 

Helgason CM, Frank JL, Johnson DR, Frank MG and Hendricks SE: The effects of St. John’s Wort (Hypericum perforatum) on NK cell activity in vitro. Immunopharmacology. 46:247–251. 2000.

13 

Ishiguro K, Yamaki M, Kashihara M and Takagi S: Sarothralen A and B, new antibiotic compounds from Hypericum japonicum. Planta Med. 52:288–290. 1986. View Article : Google Scholar

14 

Wu QL, Wang SP, Du LJ, Yang JS and Xiao PG: Xanthones from Hypericum japonicum and H. henryi. Phytochemistry. 49:1395–1402. 1998.PubMed/NCBI

15 

Wang XW, Mao Y, Wang NL and Yao XS: A new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb. Molecules. 13:2796–2803. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Dai Y, Desano J, Qu Y, Tang W, Meng Y, Lawrence TS and Xu L: Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer. Am J Cancer Res. 1:128–143. 2011.PubMed/NCBI

17 

Ding M, Zhao J, Bowman L, Lu Y and Shi X: Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin. Int J Oncol. 36:59–67. 2010.PubMed/NCBI

18 

Lin JP, Yang JS, Lu CC, Chiang JH, Wu CL, Lin JJ, Lin HL, Yang MD, Liu KC, Chiu TH and Chung JG: Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo. Leuk Res. 33:823–828. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Lu P, Cao W, Zhang Z and Meng X: The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy. Mol Clin Oncol 1: 395-399, 2013.
APA
Zhang, H., Lu, P., Cao, W., Zhang, Z., & Meng, X. (2013). The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy. Molecular and Clinical Oncology, 1, 395-399. https://doi.org/10.3892/mco.2012.52
MLA
Zhang, H., Lu, P., Cao, W., Zhang, Z., Meng, X."The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy". Molecular and Clinical Oncology 1.2 (2013): 395-399.
Chicago
Zhang, H., Lu, P., Cao, W., Zhang, Z., Meng, X."The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy". Molecular and Clinical Oncology 1, no. 2 (2013): 395-399. https://doi.org/10.3892/mco.2012.52
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Lu P, Cao W, Zhang Z and Meng X: The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy. Mol Clin Oncol 1: 395-399, 2013.
APA
Zhang, H., Lu, P., Cao, W., Zhang, Z., & Meng, X. (2013). The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy. Molecular and Clinical Oncology, 1, 395-399. https://doi.org/10.3892/mco.2012.52
MLA
Zhang, H., Lu, P., Cao, W., Zhang, Z., Meng, X."The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy". Molecular and Clinical Oncology 1.2 (2013): 395-399.
Chicago
Zhang, H., Lu, P., Cao, W., Zhang, Z., Meng, X."The effect-enhancing and toxicity-reducing activity of Hypericum japonicum Thunb. extract in murine liver cancer chemotherapy". Molecular and Clinical Oncology 1, no. 2 (2013): 395-399. https://doi.org/10.3892/mco.2012.52
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