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Article

Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy

  • Authors:
    • Seung-Kwon Choi
    • Gyeong Eun Min
    • Seung Hyun Jeon
    • Hyung-Lae Lee
    • Sung-Goo Chang
    • Koo Han Yoo
  • View Affiliations / Copyright

    Affiliations: Department of Urology, School of Medicine, Kyung Hee University, Seoul 134-727, Republic of Korea
  • Pages: 365-368
    |
    Published online on: December 24, 2012
       https://doi.org/10.3892/mco.2012.55
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Abstract

The anti‑angiogenic properties of statins, widely used for the treatment of hyperlipidemia, have recently been reported. The aim of this study was to investigate the effects of use of statins for the management of post‑operative recurrence and progression of renal cell carcinoma (RCC). Of 306 patients diagnosed with kidney cancer between January, 2006 and June, 2012, 115 patients who showed no distant metastasis and had undergone radical or partial nephrectomy were selected. These patients were divided into a group that took statins and a group that did not. The effects of statins on the progression and recurrence of renal cancer were retrospectively analyzed. The demographics of the statins group showed that there were more males (P=0.039) and that they were of older age [mean age, 65.24 (±6.82) vs. 58.95 (±12.33) years; P=0.039] and of higher body mass index (BMI) [26.17 (±2.96) vs. 24.24 (±3.35), P=0.017]. Recurrence‑free survival in the two groups showed 59.44 and 66.72 months for the statin and non‑statin groups, respectively, with no statistically significant difference (P=0.586). Progression‑free survival also showed no statistically significant difference between the two groups (P=0.307). Results of the multivariate analysis using Cox's regression model revealed that gender, age and BMI had no significance as prognostic factors for the recurrence and progression of renal cancer (P>0.05). Findings of the present study demonstrated that statins do not have a marked effect on the recurrence and progression of renal cancer. Therefore, further investigation using a larger patient group should be conducted for future statistical analysis.
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1 

Liu W, Choueiri TK and Cho E: Statin use and the risk of renal cell carcinoma in 2 prospective US cohorts. Cancer. 118797–803. 2012.PubMed/NCBI

2 

Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 360:7–22. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Hebert PR, Gaziano JM, Chan KS and Hennekens CH: Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials. JAMA. 278:313–321. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Forrester JS and Libby P: The inflammation hypothesis and its potential relevance to statin therapy. Am J Cardiol. 99:732–738. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Demierre MF, Higgins PD, Gruber SB, Hawk E and Lippman SM: Statins and cancer prevention. Nat Rev Cancer. 5:930–942. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Goldstein JL and Brown MS: Regulation of the mevalonate pathway. Nature. 343:425–430. 1990. View Article : Google Scholar : PubMed/NCBI

7 

Woodard J, Sassano A, Hay N and Platanias LC: Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma. Clin Cancer Res. 14:4640–4649. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Khurana V, Caldito G and Ankem M: Statins might reduce risk of renal cell carcinoma in humans: case-control study of 500,000 veterans. Urology. 71:118–122. 2008. View Article : Google Scholar

9 

Sivaprasad U, Abbas T and Dutta A: Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells. Mol Cancer Ther. 5:2310–2316. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Shepherd J, Cobbe SM, Ford I, et al: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 333:1301–1307. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Sacks FM, Pfeffer MA, Moye LA, et al: The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. N Engl J Med. 335:1001–1009. 1996. View Article : Google Scholar

12 

Young-Xu Y, Jabbour S, Goldberg R, et al: Usefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery disease. Am J Cardiol. 92:1379–1383. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Cipollone F, Fazia M, Iezzi A, et al: Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans. Circulation. 107:1479–1485. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Krupski WC, Layug EL, Reilly LM, et al: Comparison of cardiac morbidity between aortic and infrainguinal operations. Study of Perioperative Ischemia (SPI) Research Group. J Vasc Surg. 15:354–365. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Bax L, Mali WP, Buskens E, et al: The benefit of STent placement and blood pressure and lipid-lowering for the prevention of progression of renal dysfunction caused by Atherosclerotic ostial stenosis of the Renal artery. The STAR-study: rationale and study design. J Nephrol. 16:807–812. 2003.

16 

Farmer JA: Pleiotropic effects of statins. Curr Atheroscler Rep. 2:208–217. 2000. View Article : Google Scholar

17 

Rao S, Lowe M, Herliczek TW, et al: Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53. Oncogene. 17:2393–2402. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Vincent L, Chen W, Hong L, et al: Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett. 495:159–166. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Cafforio P, Dammacco F, Gernone A, et al: Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 26:883–891. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Marcelli M, Cunningham GR, Haidacher SJ, et al: Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res. 58:76–83. 1998.PubMed/NCBI

21 

Hindler K, Cleeland CS, Rivera E and Collard CD: The role of statins in cancer therapy. Oncologist. 11:306–315. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Coogan PF, Rosenberg L, Palmer JR, et al: Statin use and the risk of breast and prostate cancer. Epidemiology. 13:262–267. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Poynter JN, Gruber SB, Higgins PD, et al: Statins and the risk of colorectal cancer. N Engl J Med. 352:2184–2192. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Strandberg TE, Pyorala K, Cook TJ, et al: Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet. 364:771–777. 2004.PubMed/NCBI

25 

ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs. usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). JAMA. 288:2998–3007. 2002. View Article : Google Scholar

26 

Simes RJ, Marschner IC, Hunt D, et al: Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Trial: to what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels? Circulation. 105:1162–1169. 2002. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Choi S, Min GE, Jeon SH, Lee H, Chang S and Yoo KH: Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy. Mol Clin Oncol 1: 365-368, 2013.
APA
Choi, S., Min, G.E., Jeon, S.H., Lee, H., Chang, S., & Yoo, K.H. (2013). Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy. Molecular and Clinical Oncology, 1, 365-368. https://doi.org/10.3892/mco.2012.55
MLA
Choi, S., Min, G. E., Jeon, S. H., Lee, H., Chang, S., Yoo, K. H."Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy". Molecular and Clinical Oncology 1.2 (2013): 365-368.
Chicago
Choi, S., Min, G. E., Jeon, S. H., Lee, H., Chang, S., Yoo, K. H."Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy". Molecular and Clinical Oncology 1, no. 2 (2013): 365-368. https://doi.org/10.3892/mco.2012.55
Copy and paste a formatted citation
x
Spandidos Publications style
Choi S, Min GE, Jeon SH, Lee H, Chang S and Yoo KH: Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy. Mol Clin Oncol 1: 365-368, 2013.
APA
Choi, S., Min, G.E., Jeon, S.H., Lee, H., Chang, S., & Yoo, K.H. (2013). Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy. Molecular and Clinical Oncology, 1, 365-368. https://doi.org/10.3892/mco.2012.55
MLA
Choi, S., Min, G. E., Jeon, S. H., Lee, H., Chang, S., Yoo, K. H."Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy". Molecular and Clinical Oncology 1.2 (2013): 365-368.
Chicago
Choi, S., Min, G. E., Jeon, S. H., Lee, H., Chang, S., Yoo, K. H."Effects of statins on the prognosis of local and locally advanced renal cell carcinoma following nephrectomy". Molecular and Clinical Oncology 1, no. 2 (2013): 365-368. https://doi.org/10.3892/mco.2012.55
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