Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2013 Volume 1 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system

  • Authors:
    • Masashi Nomura
    • Yoshitaka Narita
    • Yasuji Miyakita
    • Makoto Ohno
    • Shintaro Fukushima
    • Takashi Maruyama
    • Yoshihiro Muragaki
    • Soichiro Shibui
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery and Neuro‑Oncology, National Cancer Center, Tokyo 104‑0045, Japan, Division of Pathology and Clinical Laboratories, National Cancer Center, Tokyo 104‑0045, Japan, Department of Neurosurgery, Tokyo Women's Medical University, Tokyo 116‑8567, Japan
  • Pages: 655-660
    |
    Published online on: April 30, 2013
       https://doi.org/10.3892/mco.2013.110
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The majority of primary central nervous system (CNS) lymphomas are diffuse large B‑cell lymphomas (DLBCLs) and anaplastic large‑cell lymphoma (ALCL) is a type of T‑cell tumor that is rare in the CNS. The aim of this study was to elucidate the clinical presentation and standard therapy of ALCLs by investigating reported cases. Additionally, a case of anaplastic lymphoma kinase (ALK)‑positive ALCL in a 20‑year‑old man who exhibited no recurrence for >5 years following high‑dose methotrexate (HD‑MTX) treatment was described. Twenty‑six immunocompetent patients with ALCL of the CNS that were previously reported and 1 case of ALCL of the CNS treated at our hospital were investigated. Overall survival (OS) was analyzed in relation to survival factors such as age, ALK status and the treatment regimen. The male:female ratio of the patients was 19:8. Of the 27 patients, 13 (48.1%) were ALK‑positive, 9 (33.3%) were ALK‑negative and the ALK status was not determined in the remaining 5 patients (18.5%). ALK‑positive ALCL occurred at a younger age (median age, 17 years) and exhibited a favorable course (5‑year OS, 75.0%), whereas ALK‑negative ALCL presented at an older age (median age, 65 years) and resulted in fatal outcomes (5‑year OS, <12.5%). Similar to the findings for systemic ALCL, ALK positivity, age <40 years and chemotherapy are associated with long‑term survival for ALCL of the CNS. Chemoradiotherapy including methotrexate is recommended for ALCL and the possibility of treatment with chemotherapy alone for ALK‑positive ALCL is currently under consideration.
View Figures

Figure 1

Figure 2

View References

1. 

The committee of Brain Tumor Registry of Japan: Report of brain tumor registry of Japan (1984–2000) 12th edition. Neurol Med Chir (Tokyo). 49(Suppl): 1–101. 2009.

2. 

Ferreri AJ, Blay JY, Reni M, et al: Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol. 21:266–272. 2003. View Article : Google Scholar : PubMed/NCBI

3. 

Hayabuchi N, Shibamoto Y and Onizuka Y: Primary central nervous system lymphoma in Japan: a nationwide survey. Int J Radiat Oncol Biol Phys. 44:265–272. 1999. View Article : Google Scholar : PubMed/NCBI

4. 

Ferreri AJ, Reni M, Pasini F, et al: A multicenter study of treatment of primary CNS lymphoma. Neurology. 58:1513–1520. 2002. View Article : Google Scholar : PubMed/NCBI

5. 

Shenkier TN, Blay JY, O’Neill BP, et al: Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group. J Clin Oncol. 23:2233–2239. 2005. View Article : Google Scholar : PubMed/NCBI

6. 

Stein H, Mason DY, Gerdes J, et al: The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 66:848–858. 1985.

7. 

Jaffe ES, Harris NL, Stein H and Vardiman JW: Anaplastic large cell lymphoma. Pathology and Genetics: Tumors of Haematopoietic and Lymphoid Tissues. Jaffe ES, Harris NL, Stein H, Vardiman JW, et al: IARC Press; pp. 230–235. Lyon: 2001

8. 

Swerdlow S, Campo E, Harris N, et al: Anaplastic large cell lymphoma WHO classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. IARC Press; pp. 312–319. Lyon; 2008

9. 

Stein H, Foss HD, Durkop H, et al: CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 96:3681–3695. 2000.

10. 

Suzuki R, Kagami Y, Takeuchi K, et al: Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype. Blood. 96:2993–3000. 2000.PubMed/NCBI

11. 

Falini B, Pileri S, Zinzani PL, et al: ALK+ lymphoma: clinico-pathological findings and outcome. Blood. 93:2697–2706. 1999.

12. 

Abdulkader I, Cameselle-Teijeiro J, Fraga M, Rodriguez-Nunez A, Allut AG and Forteza J: Primary anaplastic large cell lymphoma of the central nervous system. Hum Pathol. 30:978–981. 1999. View Article : Google Scholar : PubMed/NCBI

13. 

George DH, Scheithauer BW, Aker FV, et al: Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression. Am J Surg Pathol. 27:487–493. 2003. View Article : Google Scholar : PubMed/NCBI

14. 

Kodama K, Hokama M, Kawaguchi K, Tanaka Y and Hongo K: Primary ALK-1-negative anaplastic large cell lymphoma of the brain: case report and review of the literature. Neuropathology. 29:166–171. 2009. View Article : Google Scholar : PubMed/NCBI

15. 

Havlioglu N, Manepalli A, Galindo L, Sotelo-Avila C and Grosso L: Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord. Am J Clin Pathol. 103:496–499. 1995.PubMed/NCBI

16. 

Buxton N, Punt J and Hewitt M: Primary Ki-1-positive T-cell lymphoma of the brain in a child. Pediatr Neurosurg. 29:250–252. 1998. View Article : Google Scholar : PubMed/NCBI

17. 

Ponzoni M, Terreni MR, Ciceri F, et al: Primary brain CD30+ ALK1+ anaplastic large cell lymphoma (‘ALKoma’): the first case with a combination of ‘not common’ variants. Ann Oncol. 13:1827–1832. 2002.

18. 

Rupani A, Modi C, Desai S and Rege J: Primary anaplastic large cell lymphoma of central nervous system - a case report. J Postgrad Med. 51:326–327. 2005.PubMed/NCBI

19. 

Cooper PB, Auerbach A, Aguilera NS, et al: Rare primary CNS anaplastic large cell lymphoma in an immunocompetent adult: a clinical-pathologic case report and review case of the literature. Clin Neuropathol. 25:232–236. 2006.PubMed/NCBI

20. 

Karikari IO, Thomas KK, Lagoo A, Cummings TJ and George TM: Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review. Pediatr Neurosurg. 43:516–521. 2007. View Article : Google Scholar : PubMed/NCBI

21. 

Abla O, Sandlund JT, Sung L, et al: A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Pediatr Blood Cancer. 47:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

22. 

Vivekanandan S, Dickinson P, Bessell E and O’Connor S: An unusual case of primary anaplastic large cell central nervous system lymphoma: an 8-year success story. BMJ Case Rep. Feb 24–2011.(Epub ahead of print). View Article : Google Scholar

23. 

Carmichael MG: Central nervous system anaplastic large cell lymphoma in an adult: successful treatment with a combination of radiation and chemotherapy. Mil Med. 172:673–675. 2007.PubMed/NCBI

24. 

Chuang SS, Huang W, Lin CN, et al: Primary cerebral anaplastic large cell lymphoma containing abundant reactive histiocytes and eosinophils. A case report and literature review. Pathol Res Pract. 197:647–652. 2001.

25. 

Paulus W, Ott MM, Strik H, Keil V and Muller-Hermelink HK: Large cell anaplastic (KI-1) brain lymphoma of T-cell genotype. Hum Pathol. 25:1253–1256. 1994. View Article : Google Scholar : PubMed/NCBI

26. 

Nuckols JD, Liu K, Burchette JL, McLendon RE and Traweek ST: Primary central nervous system lymphomas: a 30-year experience at a single institution. Mod Pathol. 12:1167–1173. 1999.PubMed/NCBI

27. 

Gonzales M: Primary meningeal anaplastic large cell lymphoma. Pathology. 35:451–452. 2003.PubMed/NCBI

28. 

Sugino T, Mikami T, Akiyama Y, Wanibuchi M, Hasegawa T and Mikuni N: Primary central nervous system anaplastic large-cell lymphoma mimicking lymphomatosis cerebri. Brain Tumor Pathol. Mar 18–2012.(Epub ahead of print).

29. 

Colen CB, Rayes M, Kupsky WJ and Guthikonda M: Synchronous meningioma and anaplastic large cell lymphoma. Neuropathology. 30:260–266. 2010. View Article : Google Scholar : PubMed/NCBI

30. 

Bergmann M and Edel G: Primary intracerebral non-Hodgkin’s lymphoma. Pathologe. 12:246–253. 1991.(In German).

31. 

Feldges A, Gerhard L, Reinhardt V and Budach V: Primary cerebral anaplastic T-cell-lymphoma (type Ki-1): review and case report. Clin Neuropathol. 11:55–59. 1992.PubMed/NCBI

32. 

Goldbrunner R, Warmuth-Metz M, Tonn JC, Vince GH and Roosen K: Primary Ki-1-positive T-cell lymphoma of the brain - an aggressive subtype of lymphoma: case report and review of the literature. Surg Neurol. 46:37–41. 1996. View Article : Google Scholar : PubMed/NCBI

33. 

Ozkaynak MF: Favorable outcome of primary CNS anaplastic large cell lymphoma in an immunocompetent patient. J Pediatr Hematol Oncol. 31:128–130. 2009. View Article : Google Scholar : PubMed/NCBI

34. 

Abla O and Weitzman S: Primary central nervous system lymphoma in children. Neurosurg Focus. 21:E82006. View Article : Google Scholar : PubMed/NCBI

35. 

O’Neill BP, O’Fallon JR, Earle JD, Colgan JP, Brown LD and Krigel RL: Primary central nervous system non-Hodgkin’s lymphoma: survival advantages with combined initial therapy? Int J Radiat Oncol Biol Phys. 33:663–673. 1995.

36. 

Schultz C, Scott C, Sherman W, et al: Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas: initial report of radiation therapy oncology group protocol 88-06. J Clin Oncol. 14:556–564. 1996.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nomura M, Narita Y, Miyakita Y, Ohno M, Fukushima S, Maruyama T, Muragaki Y and Shibui S: Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system. Mol Clin Oncol 1: 655-660, 2013.
APA
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T. ... Shibui, S. (2013). Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system. Molecular and Clinical Oncology, 1, 655-660. https://doi.org/10.3892/mco.2013.110
MLA
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T., Muragaki, Y., Shibui, S."Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system". Molecular and Clinical Oncology 1.4 (2013): 655-660.
Chicago
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T., Muragaki, Y., Shibui, S."Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system". Molecular and Clinical Oncology 1, no. 4 (2013): 655-660. https://doi.org/10.3892/mco.2013.110
Copy and paste a formatted citation
x
Spandidos Publications style
Nomura M, Narita Y, Miyakita Y, Ohno M, Fukushima S, Maruyama T, Muragaki Y and Shibui S: Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system. Mol Clin Oncol 1: 655-660, 2013.
APA
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T. ... Shibui, S. (2013). Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system. Molecular and Clinical Oncology, 1, 655-660. https://doi.org/10.3892/mco.2013.110
MLA
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T., Muragaki, Y., Shibui, S."Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system". Molecular and Clinical Oncology 1.4 (2013): 655-660.
Chicago
Nomura, M., Narita, Y., Miyakita, Y., Ohno, M., Fukushima, S., Maruyama, T., Muragaki, Y., Shibui, S."Clinical presentation of anaplastic large‑cell lymphoma in the central nervous system". Molecular and Clinical Oncology 1, no. 4 (2013): 655-660. https://doi.org/10.3892/mco.2013.110
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team