Clinicopathological significance of deoxycytidine kinase expression in esophageal squamous cell carcinoma

Shimada,Yutaka; Okumura,Tomoyuki; Sekine,Shinichi; Moriyama,Makoto; Hojo,Shozo; Matsui,Koshi; Sawada,Shigeaki; Nagata,Takuya; Fukuoka,Junya; Tsukada,Kazuhiro

doi:10.3892/mco.2013.114

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

Clinicopathological significance of deoxycytidine kinase expression in esophageal squamous cell carcinoma

Authors:
- Yutaka Shimada
- Tomoyuki Okumura
- Shinichi Sekine
- Makoto Moriyama
- Shozo Hojo
- Koshi Matsui
- Shigeaki Sawada
- Takuya Nagata
- Junya Fukuoka
- Kazuhiro Tsukada
View Affiliations / Copyright

Affiliations: Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan, Department of Surgical Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
Pages: 716-720
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Published online on: May 9, 2013

https://doi.org/10.3892/mco.2013.114
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Abstract

Deoxycytidine kinase (dCK) mediates the rate‑limiting catabolic step in the activation of gemcitabine. Gemcitabine is a key drug for pancreatic and biliary tract cancer. However, gemcitabine is not widely used for esophageal squamous cell carcinoma (ESCC). In this study, we analyzed the expression of dCK in ESCC and evaluated the possibility of gemcitabine treatment for ESCC. In total, 76 ESCC patients who underwent esophagectomy between 1990 and 2008 were analyzed. dCK expression was analyzed immunohistochemically using tissue microarray and compared to the clinocopathological characteristics of the patients. Results identified 41 patients positive for dCK and 35 patients negative for dCK. A significant association was observed between dCK expression and gender (P=0.01), whereas the remaining factors were not associated with dCK expression. Prognosis of the patients with a high dCK expression was significantly worse than that of the patients with a low dCK expression (P=0.022). Furthermore, dCK expression was an independent prognostic factor regarding cause‑specific prognosis (risk ratio, 2.2; P=0.031). In conclustion, the results of the present study suggested that dCK expression is a prognostic factor of the ESCC patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinicopathological significance of deoxycytidine kinase expression in esophageal squamous cell carcinoma

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Abstract

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