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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Epigenetics

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Article

Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth

  • Authors:
    • Yoshihiro Kano
    • Masamitsu Konno
    • Katsuya Ohta
    • Naotsugu Haraguchi
    • Shimpei Nishikawa
    • Yoshinori Kagawa
    • Atsushi Hamabe
    • Shinichiro Hasegawa
    • Hisataka Ogawa
    • Takahito Fukusumi
    • Yuko Noguchi
    • Miyuki Ozaki
    • Toshihiro Kudo
    • Daisuke Sakai
    • Taroh Satoh
    • Masaru Ishii
    • Eiichi Mizohata
    • Takeshi Inoue
    • Masaki Mori
    • Yuichiro Doki
    • Hideshi Ishii
  • View Affiliations / Copyright

    Affiliations: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan, Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan, Department of Otorhinolaryngology‑Head and Neck Surgery, Osaka University, Graduate School of Medicine, Suita, Osaka 565-0871, Japan, Laboratory of Cellular Dynamics, WPI‑Immunology Frontier Research Center, Osaka University, Suita, Osaka 565‑0871, Japan, Osaka University, Graduate School of Technology, Suita, Osaka 565-0871, Japan
  • Pages: 753-757
    |
    Published online on: May 21, 2013
       https://doi.org/10.3892/mco.2013.127
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Abstract

Although esophageal cancer is highly heterogeneous and the involvement of epigenetic regulation of cancer stem cells is highly suspected, the biological significance of epigenetically modified molecules that regulate different subpopulations remains to be firmly established. Using esophageal cancer cells, we investigated the functional roles of the H3K4 demethylase Jumonji/Arid1b (Jarid1b) (Kdm5b/Plu‑1/Rbp2‑h1), an epigenetic factor that is required for continuous cell growth in melanoma. JARID1B knockdown resulted in the suppression of esophageal cancer cell growth, sphere formation and invasion ability and was associated with loss of epithelial marker expression. However, these inhibitory effects observed on tumor formation were reverted subsequent to subcutaneous inoculation of these cells into immune‑deficient mice. These results indicated that JARID1B plays a role in maintaining cancer stem cells in the esophagus and justifies the rationale for studying the effects of continuous inhibition of this epigenetic factor in esophageal cancer.
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1. 

Hansson LE, Sparen P and Nyren O: Increasing incidence of both major histological types of esophageal carcinomas among men in Sweden. Int J Cancer. 54:402–407. 1993. View Article : Google Scholar : PubMed/NCBI

2. 

Ozols R: Esophageal cancer. Curr Problems Cancer. XVIII:191–246. 1994.

3. 

Conteduca V, Sansonno D, Ingravallo G, Marangi S, Russi S, Lauletta G and Dammacco F: Barrett’s esophagus and esophageal cancer: An overview. Int J Oncol. 41:414–424. 2012.

4. 

di Pietro M, Lao-Sirieix P, Boyle S, Cassidy A, Castillo D, Saadi A, Eskeland R and Fitzgerald RC: Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus. Proc Natl Acad Sci USA. 109:9077–9082. 2012.PubMed/NCBI

5. 

Coia LR: The esophagus. Moss’ Radiation Oncology: Rationale, Techniques, Results. Cox J: Mosby-Year Book; St. Louise: pp. 4091994

6. 

Follis RH Jr: The pathology of zinc deficiency. Zinc Metabolism. Prasad AS: Springfield; pp. 129–141. 1966

7. 

Taccioli C, Chen H, Jiang Y, Liu XP, Huang K, Smalley KJ, Farber JL, Croce CM and Fong LY: Dietary zinc deficiency fuels esophageal cancer development by inducing a distinct inflammatory signature. Oncogene. 31:4550–4558. 2012. View Article : Google Scholar : PubMed/NCBI

8. 

Alder H, Taccioli C, Chen H, Jiang Y, Smalley KJ, Fadda P, Ozer HG, Huebner K, Farber JL, Croce CM and Fong LY: Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. Carcinogenesis. 33:1736–1744. 2012. View Article : Google Scholar : PubMed/NCBI

9. 

Kaz AM and Grady WM: Epigenetic biomarkers in esophageal cancer. Cancer Lett. Mar 7–2012.(Epub ahead of print).

10. 

Shoji M, Ninomiya I, Makino I, Kinoshita J, Nakamura K, Oyama K, Nakagawara H, Fujita H, Tajima H, Takamura H, Kitagawa H, Fushida S, Harada S, Fujimura T and Ohta T: Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. Int J Oncol. 40:2140–2146. 2012.PubMed/NCBI

11. 

Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, Basu D, Gimotty P, Vogt T and Herlyn M: A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell. 141:583–594. 2010. View Article : Google Scholar : PubMed/NCBI

12. 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar

13. 

Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

14. 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J and Weinberg RA: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

15. 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

16. 

Dewi DL, Ishii H, Kano Y, Nishikawa S, Haraguchi N, Sakai D, Satoh T, Doki Y and Mori M: Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges. J Gastroenterol. 46:1145–1157. 2011. View Article : Google Scholar : PubMed/NCBI

17. 

Chicas A, Kapoor A, Wang X, Aksoy O, Evertts AG, Zhang MQ, Garcia BA, Bernstein E and Lowe SW: H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proc Natl Acad Sci USA. 109:8971–8976. 2012. View Article : Google Scholar : PubMed/NCBI

18. 

Rayess H, Wang MB and Srivatsan ES: Cellular senescence and tumor suppressor gene p16. Int J Cancer. 130:1715–1725. 2012. View Article : Google Scholar : PubMed/NCBI

19. 

Vurusaner B, Poli G and Basaga H: Tumor suppressor genes and ROS: complex networks of interactions. Free Radic Biol Med. 52:7–18. 2012. View Article : Google Scholar : PubMed/NCBI

20. 

Schrump DS, Chen GA, Consuli U, Jin X and Roth JA: Inhibition of esophageal cancer proliferation by adenovirally mediated delivery of p16INK4. Cancer Gene Ther. 3:357–364. 1996.PubMed/NCBI

21. 

Matsubara H, Tagawa M, Gunji Y, Takenaga K, Sugaya M, Urashima T, Koide Y, Suzuki T, Asano T, Ochiai T, Isono K, Kageyama H, Nakamura Y and Sakiyama S: Study of irradiation effects on cytokine secretion from retrovirally-transduced tumor cells: a model for tumor vaccination. Anticancer Res. 16:645–650. 1996.PubMed/NCBI

22. 

Matsubara H, Koide Y, Sugaya M, Gunji Y, Asano T, Ochiai T, Takegana K, Sakiyama S and Tagawa M: Antitumor response of genetically engineered IL-2 expression to human esophageal carcinoma cells in mature T cell-defective condition. Int J Oncol. 13:1217–1239. 1998.

23. 

Miyauchi M, Shimada H, Kadomatsu K, Muramatsu T, Matsubara S, Ikematsu S, Takenaga K, Asano T, Ochiai T, Sakiyama S and Tagawa M: Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy. Jpn J Cancer Res. 90:469–475. 1999. View Article : Google Scholar : PubMed/NCBI

24. 

Matsubara H, Kawamura K, Sugaya M, Koide Y, Gunji Y, Takenaga K, Asano T, Ochiai T, Sakiyama S and Tagawa M: Differential efficacy of suicide gene therapy by herpes simplex virus-thymidine kinase gene reflects the status of p53 gene in human esophageal cancer cells. Anticancer Res. 19:4157–4160. 1999.

25. 

Yamamoto T, Nakatani M, Narukawa K and Obika S: Antisense drug discovery and development. Future Med Chem. 3:339–365. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kano Y, Konno M, Ohta K, Haraguchi N, Nishikawa S, Kagawa Y, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Fukusumi T, et al: Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Mol Clin Oncol 1: 753-757, 2013.
APA
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y. ... Ishii, H. (2013). Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Molecular and Clinical Oncology, 1, 753-757. https://doi.org/10.3892/mco.2013.127
MLA
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H."Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth". Molecular and Clinical Oncology 1.4 (2013): 753-757.
Chicago
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H."Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth". Molecular and Clinical Oncology 1, no. 4 (2013): 753-757. https://doi.org/10.3892/mco.2013.127
Copy and paste a formatted citation
x
Spandidos Publications style
Kano Y, Konno M, Ohta K, Haraguchi N, Nishikawa S, Kagawa Y, Hamabe A, Hasegawa S, Ogawa H, Fukusumi T, Fukusumi T, et al: Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Mol Clin Oncol 1: 753-757, 2013.
APA
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y. ... Ishii, H. (2013). Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. Molecular and Clinical Oncology, 1, 753-757. https://doi.org/10.3892/mco.2013.127
MLA
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H."Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth". Molecular and Clinical Oncology 1.4 (2013): 753-757.
Chicago
Kano, Y., Konno, M., Ohta, K., Haraguchi, N., Nishikawa, S., Kagawa, Y., Hamabe, A., Hasegawa, S., Ogawa, H., Fukusumi, T., Noguchi, Y., Ozaki, M., Kudo, T., Sakai, D., Satoh, T., Ishii, M., Mizohata, E., Inoue, T., Mori, M., Doki, Y., Ishii, H."Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth". Molecular and Clinical Oncology 1, no. 4 (2013): 753-757. https://doi.org/10.3892/mco.2013.127
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