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Molecular and Clinical Oncology
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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer

  • Authors:
    • Xiaoyi Wang
    • Changing Gan
    • Hongyuan Li
    • Yuxian Wei
    • Donchang Zhu
    • Guanglun Yang
    • Xinliang Su
    • Jean-François Rodier
    • Guosheng Ren
  • View Affiliations / Copyright

    Affiliations: Department of Breast and Endocrine Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China, Department of Surgical Oncology, Paul Strauss Cancer Center, 67065 Strasbourg, France
  • Pages: 745-748
    |
    Published online on: May 23, 2013
       https://doi.org/10.3892/mco.2013.129
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Abstract

Intra‑arterial infusion chemotherapy for locally advanced breast cancer (LABC) has been previously performed. However, the main complications of this type of chemotherapy remain to be clarified. In the present study, catheterization chemotherapy was carried out for 53 LABC cases (stage Ⅲa-Ⅲc) between May, 2006 and March, 2007. For ⅢB and ⅢC patients, the catheters were guided to the opening of the subclavian artery. For stage Ⅲa patients, the catheters were placed into the thoracic artery through a subcutaneous femoral artery puncture. One to four cycles of chemotherapy (mean, 1.6 cycles) were administered for the patients using taxotere, epidoxorubicin, 5-fluorouracil and/or cyclophosphamide. The interval time between the two cycles was 21 days. Seven cases were identified as complete response (CR, 13.2%), 41 cases were partial response (PR, 77.4%) with a rate of effectiveness of (CR + PR, 90.6%), 5 cases were stable disease (SD, 9.40%) and no case was progressive. Pain of the ipsilateral upper extremity was present in 7 cases. Two cases exhibited ipsilateral upper extremity atrophy following drug administration from the opening of the subclavian artery. One case experienced neck pain and headache, while in one case necrosis of local skin was evident. Hematological toxicity over grade 3 was observed in 6 cases (11.30%). Systemic toxicity was mild and did not affect the quality of life of the patients. Overall survival was identified as 18/51 (35.3%), and free‑disease survival as 10/51 (19.6%). In conclusion, intra-arterial infusion chemotherapy is an effective local control treatment for LABC. The main complications are pain of the ipsilateral upper extremity and neck as well as headache. Severe complications are ipsilateral upper extremity atrophy and necrosis of local skin. During the treatment, controlling the pressure of the tourniquet and velocity of drug administration are crucial for reducing local complications.
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1. 

Singletary SE, Allred C, Ashley P, et al: Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 20:3628–3636. 2002. View Article : Google Scholar : PubMed/NCBI

2. 

Kaufmann M, von Minckwitz G, Bear HD, et al: Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006. Ann Oncol. 18:1927–1934. 2007. View Article : Google Scholar : PubMed/NCBI

3. 

Olson JE, Neuberg D, Pandya KJ, et al: The role of radiotherapy in the management of operable locally advanced breast carcinoma: results of a randomized trial by the Eastern Cooperative Oncology Group. Cancer. 79:1138–1149. 1997. View Article : Google Scholar

4. 

Murakami M, Kuroda Y, Nishimura S, et al: Intraarterial infusion chemotherapy and radiotherapy with or without surgery for patients with locally advanced or recurrent breast cancer. Am J Clin Oncol. 24:185–191. 2001. View Article : Google Scholar : PubMed/NCBI

5. 

Kitagawa K, Yamakado K, Nakatsuka A, et al: Preoperative transcatheter arterial infusion chemotherapy for locally advanced breast cancer (stageIIIb) for down-staging and increase of respectability. Eur J Radiol. 43:31–36. 2002. View Article : Google Scholar

6. 

Fiorentini G, Tsetis D, Bernardeschi P, et al: First-line intra-arterial chemotherapy (IAC) with epirubicin and mitoxantrone in locally advanced breast cancer. Anticancer Res. 23:4339–4345. 2003.PubMed/NCBI

7. 

Pacetti P, Mambrini A, Paolucci R, et al: Intra-arterial chemotherapy: a safe treatment for elderly patients with locally advanced breast cancer. In Vivo. 20:761–764. 2006.PubMed/NCBI

8. 

Shimamoto H, Takizawa K, Ogawa Y, et al: Clinical efficacy and value of redistributed subclavian arterial infusion chemotherapy for locally advanced breast cancer. Jpn J Radiol. 29:236–243. 2011. View Article : Google Scholar : PubMed/NCBI

9. 

Shenkier T, Weir L, Levine M, et al: Steering committee on clinical practice guidelines for the care and treatment of breast cancer. Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer. CMAJ. 170:983–994. 2004. View Article : Google Scholar

10. 

Huang EH, Tucker SL, Strom EA, et al: Predictors of locoregional recurrence in patients with locally advanced breast cancer treated with neoadjuvant chemotherapy, mastectomy, and radiotherapy. Int J Radiat Oncol Biol Phys. 62:351–357. 2005. View Article : Google Scholar : PubMed/NCBI

11. 

Fisher B, Bryant J, Wolmark N, et al: Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J Clin Oncol. 16:2672–2685. 1998.PubMed/NCBI

12. 

Wolmark N, Wang J, Mamounas E, et al: Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National surgical adjuvant breast and bowel project B-18. J Natl Cancer Inst Monogr. 30:96–102. 2001.PubMed/NCBI

13. 

van der Hage JA, van de Velde CJ, Julien JP, et al: Preoperative chemotherapy in primary operable breast cancer: results from the European organization for Research and Treatment of Cancer trial 10902. J Clin Oncol. 19:4224–4237. 2001.

14. 

Mauriac L, MacGrogan G, Avril A, et al: Neoadjuvant chemotherapy for operable breast carcinoma larger than 3 cm: a unicentre randomized trial with a 124-month medial follow-up. Institut Bergonié Bordeaux Groupe Sein (IBBGS). Ann Oncol. 10:47–52. 1999.PubMed/NCBI

15. 

Eniu A, Palmieri FM and Perez EA: Weekly administration of docetaxel and paclitaxel in metastatic or advanced breast cancer. Oncologist. 10:665–685. 2005. View Article : Google Scholar : PubMed/NCBI

16. 

Heller W, Mazhar D, Ward R, et al: Neoadjuvant 5-fluorouracil epirubicin and cyclophosphamide chemotherapy followed by docetaxel in refractory patients with locally advanced breast cancer. Oncol Rep. 17:253–259. 2007.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Gan C, Li H, Wei Y, Zhu D, Yang G, Su X, Rodier J and Ren G: Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer. Mol Clin Oncol 1: 745-748, 2013.
APA
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G. ... Ren, G. (2013). Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer. Molecular and Clinical Oncology, 1, 745-748. https://doi.org/10.3892/mco.2013.129
MLA
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G., Su, X., Rodier, J., Ren, G."Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer". Molecular and Clinical Oncology 1.4 (2013): 745-748.
Chicago
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G., Su, X., Rodier, J., Ren, G."Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer". Molecular and Clinical Oncology 1, no. 4 (2013): 745-748. https://doi.org/10.3892/mco.2013.129
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Gan C, Li H, Wei Y, Zhu D, Yang G, Su X, Rodier J and Ren G: Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer. Mol Clin Oncol 1: 745-748, 2013.
APA
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G. ... Ren, G. (2013). Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer. Molecular and Clinical Oncology, 1, 745-748. https://doi.org/10.3892/mco.2013.129
MLA
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G., Su, X., Rodier, J., Ren, G."Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer". Molecular and Clinical Oncology 1.4 (2013): 745-748.
Chicago
Wang, X., Gan, C., Li, H., Wei, Y., Zhu, D., Yang, G., Su, X., Rodier, J., Ren, G."Main complications and results of treatment with intra‑arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer". Molecular and Clinical Oncology 1, no. 4 (2013): 745-748. https://doi.org/10.3892/mco.2013.129
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