Increased IL‑17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers

Yazawa,Takashi; Shibata,Masahiko; Gonda,Kenji; Machida,Takeshi; Suzuki,Satoshi; Kenjo,Akira; Nakamura,Izumi; Tsuchiya,Takao; Koyama,Yoshihisa; Sakurai,Kenichi; Shimura,Tatsuo; Tomita,Ryouichi; Ohto,Hitoshi; Gotoh,Mitsukazu; Takenoshita,Seiichi

doi:10.3892/mco.2013.134

July-August 2013 Volume 1 Issue 4

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July-August 2013 Volume 1 Issue 4

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Article

Increased IL‑17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers

Authors:
- Takashi Yazawa
- Masahiko Shibata
- Kenji Gonda
- Takeshi Machida
- Satoshi Suzuki
- Akira Kenjo
- Izumi Nakamura
- Takao Tsuchiya
- Yoshihisa Koyama
- Kenichi Sakurai
- Tatsuo Shimura
- Ryouichi Tomita
- Hitoshi Ohto
- Mitsukazu Gotoh
- Seiichi Takenoshita
View Affiliations / Copyright

Affiliations: Department of Organ Regulatory Surgery, Fukushima 960‑1295, Japan, Department of Tumor and Host Bioscience, Fukushima 960‑1295, Japan, Department of Immunology, Fukushima 960‑1295, Japan, Department of Regenerative Surgery, Fukushima 960‑1295, Japan, Department of Surgery, Nihon University School of Medicine, Itabashi, Tokyo 173‑8610, Japan, Department of Surgery, Nippon Dental University, Chiyoda, Tokyo 102-8158, Japan, Department of Blood Transfusion and Transplantation Immunology, Fukushima 960‑1295, Japan
Pages: 675-679
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Published online on: May 27, 2013

https://doi.org/10.3892/mco.2013.134
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Abstract

Although a causal relationship between inflammation and innate immunity of cancer is more widely accepted today, many of the precise cell mechanisms mediating this relationship have not been elucidated. Th17 cells, which produce the proinflammatory cytokine interleukin 17 (IL‑17), have been recognized as one of the key factors in the regulation of inflammatory bowel disease and rheumatoid arthritis. This study demonstrated that, in patients with various types of gastrointestinal cancer, IL‑17 production was correlated with myeloid‑derived suppressor cell (MDSC) levels and with markers for nutritional impairment, immune suppression and chronic inflammation. IL‑17 was significantly higher in patients with various types of gastrointestinal cancer compared to normal volunteers. In addition, IL‑17 levels were significantly correlated with neutrophil counts and the neutrophil̸lymphocyte ratio (NLR) and significantly inversely correlated with cell‑mediated immune response indicators [lymphocyte phytohemagglutinin (PHA)‑blastogenesis and IL‑12 induction] and patient nutritional status (prealbumin levels). Circulating MDSC levels were significantly correlated with IL‑17 production. These results suggest that, in human gastrointestinal cancers, chronic inflammation involving IL‑17 may be an important mechanism contributing to disease progression through enhancement of immune suppression or cachexia. Controlling the activation of Th17 cells may prove to be a valuable strategy for the treatment of gastrointestinal cancer patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Increased IL‑17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers

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Abstract

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