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Article

Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085)

  • Authors:
    • Dejian Pan
    • Biao Wang
    • Xijian Zhou
    • Donglin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, 101st Hospital of PLA, Clinical Medical College of Jiangsu University, Wuxi, Jiangsu 214044, P.R. China, Department of Oncology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, P.R. China
  • Pages: 711-715
    |
    Published online on: May 27, 2013
       https://doi.org/10.3892/mco.2013.135
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Abstract

Lung cancer is one of the most commonly encountered human malignancies. Due to the increase in life expectancy as well as the incidence of lung cancer, the incidence of senile lung cancer has increased significantly. We conducted a study to evaluate the efficacy and safety of gefitinib combined with γ‑ray stereotactic body radiation therapy (SBRT) as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung. A total of 122 senile patients with adenocarcinoma of the lung were divided into 3 groups according to the treatment method. Group A included 35 patients treated with gefitinib combined with γ‑ray SBRT, group B included 45 patients treated with γ‑ray SBRT alone and group C included 42 patients treated with gefitinib alone. The patients received 250 mg of gefitinib per day, from the first day of the treatment until disease progression or discontinuation due to other causes. The patients were treated with γ‑ray SBRT, initiated on the second day. The dose curve for this case group was 50‑80%. The encircled dose was 4.0‑6.5 Gy per fraction and the range of the total radiation dose was 36‑48 Gy. The total number of treatments was 8‑12, at a frequency of 5 times per week. All 122 patients were assessed by contrast-enhanced double helical computed tomography (CT) at 2 months. The tumor response rate (RR) of group A was 68.6% (24/35), the disease control rate (DCR) was 88.6% (31/35), the median overall survival (OS) was 15.5 months (range, 3‑52 months) and the progression‑free survival (PFS) was 7.8 months. The 1‑year OS rate was 40.0% (14/35). The main side effects included skin rash and diarrhea. The RR of group B was 51.1% (23/45), the DCR was 71.1% (32/45), the OS was 9.6 months (range, 3‑22 months) and the PFS was 5.3 months. The 1‑year OS rate was 15.6% (7/45). The RR of group C was 40.5% (17/42), the DCR was 61.9% (26/42), the OS was 10.3 months (range, 3‑26 months) and the PFS was 5.1 months. The 1‑year OS rate was 35.7% (15/42). The main side effects included skin rash and diarrhea. The short‑term therapeutic effect (RR) in group A was higher compared to that in group C (P=0.014, χ2=6.053); however, there was no significant difference compared to group B (P=0.116, χ2=2.477). The PFS of group A was higher compared with that of groups B and C (7.8 vs. 5.9, P=0.018 and 7.8 vs. 5.1, P=0.013, respectively). The OS of group A was higher compared with that of groups B and C (15.5 vs. 9.6, P=0.002 and 15.5 vs. 10.3, P=0.017, respectively). No significant differences were observed in PFS and OS between groups B and C. In conclusion, gefitinib combined with γ‑ray SBRT appears to be feasible and effective as the first‑line treatment in senile patients with adenocarcinoma of the lungs.
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1. 

Cappuzzo F, Ligorio C, Jänne PA, et al: Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol. 25:2248–2255. 2007. View Article : Google Scholar

2. 

Lin CC and Yang CH: Epidermal growth factor receptor tyrosine kinase inhibitors in elderly or poor performance status patients with advanced non-small cell lung cancer. Target Oncol. 4:37–44. 2009. View Article : Google Scholar : PubMed/NCBI

3. 

Chang BW and Saif MW: Combining epidermal growth factor receptor inhibitors and radiation therapy in pancreatic cancer: small step or giant leap? JOP. 10:231–236. 2009.PubMed/NCBI

4. 

Magné N, Chargari C, Castadot P, et al: The efficacy and toxicity of EGFR in the settings of radiotherapy: focus on published clinical trials. Eur J Cancer. 44:2133–2143. 2008.PubMed/NCBI

5. 

Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar

6. 

Wiffen P, Mitchell M, Snelling M and Stoner N: Oxford Handbook of Clinical Pharmacy. 2nd edition. Oxford University Press; New York: 2007

7. 

Yoneda S: Outpatient chemotherapy for lung cancer. Gan To Kagaku Ryoho. 34:533–537. 2007.(In Japanese).

8. 

Chang A, Parikh P, Thongprasert S, et al: Gefitinib (IRESSA) in patients of Asian origin with refractory advanced non-small cell lung cancer: subset analysis from the ISEL study. J Thorac Oncol. 1:847–855. 2006. View Article : Google Scholar : PubMed/NCBI

9. 

Wu YL, Yang JJ, Lin JY, et al: Gefitinib target treatment in non-small cell lung cancer. Chin J Tuber Respir Dis. 30:98–102. 2007.(In Chinese).

10. 

Gao Z, Han B, Wang H, et al: Clinical observation of gefitinib as a first-line therapy in sixty-eight patients with advanced NSCLC. Oncol Lett. 3:1064–1068. 2012.PubMed/NCBI

11. 

Gandara DR, Davies AM, Gautschi O, et al: Epidermal growth factor receptor inhibitors plus chemotherapy in non-small-cell lung cancer: biologic rationale for combination strategies. Clin Lung Cancer. 2:S61–S67. 2007. View Article : Google Scholar : PubMed/NCBI

12. 

Tanaka T, Munshi A, Brooks C, et al: Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity. Clin Cancer Res. 14:1266–1273. 2008. View Article : Google Scholar : PubMed/NCBI

13. 

Zhuang HQ, Sun J, Yuan ZY, et al: Radiosensitizing effects of gefitinib at different administration times in vitro. Cancer Sci. 100:1520–1525. 2009. View Article : Google Scholar : PubMed/NCBI

14. 

Stinchcombe TE, Morris DE, Lee CB, et al: Induction chemo-therapy with carboplatin, irinotecan, and paclitaxel followed by high dose three-dimension conformal thoracic radiotherapy (74 Gy) with concurrent carboplatin, paclitaxel, and gefitinib in unresectable stage IIIA and stage IIIB non-small cell lung cancer. J Thorac Oncol. 3:250–257. 2008.

15. 

Fischer JR, Geiger D, Haffner UJ and Lahm H: Successful individualized and targeted therapy of an NSCLC patient with gefitinib based on a predictive assessment of the EGF-receptor mutation status. Pneumologie. 61:264–269. 2007.(In German).

16. 

Yoshida K, Yatabe Y, Park JY, et al: Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer. J Thorac Oncol. 2:22–28. 2007. View Article : Google Scholar : PubMed/NCBI

17. 

Fukuoka M, Wu Y, Thongprasert S, et al: Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small cell lung cancer in Asia (IPASS). J Clin Oncol. 29:2866–2874. 2011. View Article : Google Scholar

18. 

Zhong W, Wang M, Li L, et al: EGFR gene mutation statuses in advanced non-small cell lung cancer patients and their influence on effect of gefitinib. Chin J Lung Cancer. 15:513–520. 2012.(In Chinese).

19. 

Maemondo M, Minegishi Y, Inoue A, et al: First-line gefitinib in patients aged 75 or older with advanced non-small cell lung cancer harboring epidermal growth factor receptor mutations: NEJ 003 study. J Thorac Oncol. 7:1417–1422. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pan D, Wang B, Zhou X and Wang D: Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085). Mol Clin Oncol 1: 711-715, 2013.
APA
Pan, D., Wang, B., Zhou, X., & Wang, D. (2013). Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085). Molecular and Clinical Oncology, 1, 711-715. https://doi.org/10.3892/mco.2013.135
MLA
Pan, D., Wang, B., Zhou, X., Wang, D."Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085)". Molecular and Clinical Oncology 1.4 (2013): 711-715.
Chicago
Pan, D., Wang, B., Zhou, X., Wang, D."Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085)". Molecular and Clinical Oncology 1, no. 4 (2013): 711-715. https://doi.org/10.3892/mco.2013.135
Copy and paste a formatted citation
x
Spandidos Publications style
Pan D, Wang B, Zhou X and Wang D: Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085). Mol Clin Oncol 1: 711-715, 2013.
APA
Pan, D., Wang, B., Zhou, X., & Wang, D. (2013). Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085). Molecular and Clinical Oncology, 1, 711-715. https://doi.org/10.3892/mco.2013.135
MLA
Pan, D., Wang, B., Zhou, X., Wang, D."Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085)". Molecular and Clinical Oncology 1.4 (2013): 711-715.
Chicago
Pan, D., Wang, B., Zhou, X., Wang, D."Clinical study on gefitinib combined with γ‑ray stereotactic body radiation therapy as the first‑line treatment regimen for senile patients with adenocarcinoma of the lung (final results of JLY20080085)". Molecular and Clinical Oncology 1, no. 4 (2013): 711-715. https://doi.org/10.3892/mco.2013.135
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