Cutaneous angiosarcoma of the buttock complicated by severe thrombocytopenia: A case report

Nagao,Kaoru; Suzuki,Kayo; Yasuda,Taketoshi; Hori,Takeshi; Hachinoda,Jun; Kanamori,Masahiko; Kimura,Tomoatsu

doi:10.3892/mco.2013.141

Cutaneous angiosarcoma of the buttock complicated by severe thrombocytopenia: A case report

Authors:
- Kaoru Nagao
- Kayo Suzuki
- Taketoshi Yasuda
- Takeshi Hori
- Jun Hachinoda
- Masahiko Kanamori
- Tomoatsu Kimura
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Affiliations: Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Toyama 930‑0194, Japan, Department of Orthopaedic Surgery, Takaoka City Hospital, Takaoka, Toyama 933‑0816, Japan, Department of Human Science, Faculty of Medicine, University of Toyama, Toyama, Toyama 930‑0194, Japan
Published online on: July 2, 2013 https://doi.org/10.3892/mco.2013.141
Pages: 903-907

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Abstract

Angiosarcoma (AS) is an aggressive, malignant endothelial cell tumor of vascular or lymphatic origin, the presentation and clinical behavior of which may vary according to its location. This is the case report of a 56‑year‑old woman with cutaneous angiosarcoma (CAS) of the buttock complicated by severe thrombocytopenia. A review of the literature revealed that only nine cases of CAS with thrombocytopenia have been previously reported. The prognosis of CAS complicated by thrombocytopenia is poor, even after treatment with combined chemotherapy and radiotherapy (RT). The composite karyotype was 46,XX,t(12;20)(p13;p11.2)[3]/47,X,add(X)(q13),del(6)(q?),add(12)(p13),‑21,+2mar[2]/45,XX,der(1)add(1)(p36.3)del(1)(q41),‑20[1]/46,XX[13]. Only 13 cytogenetic cases of AS, including the present case, have been reported in the English literature thus far. In this case report, the clinical presentation and cytogenetic findings are described and the relevant literature on AS is reviewed.

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