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Molecular and Clinical Oncology
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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib

  • Authors:
    • Zhengbo Song
    • Yiping Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 875-878
    |
    Published online on: July 23, 2013
       https://doi.org/10.3892/mco.2013.156
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Abstract

Non‑small‑cell lung cancer (NSCLC) may exhibit oncogene addiction in patients who benefited from prior treatment with epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs). Preclinical data suggested that EGFR addiction persists after the development of TKI resistance, leading many clinicians to continue TKI treatment along with chemotherapy. however, this strategy has not been adequately evaluated in clinical practice. Patients who benefited from gefitinib followed by acquired resistance to this drug were reviewed in the Zhejiang Cancer Hospital. Patients were included if they received chemotherapy and gefitinib following failure of prior gefitinib treatment. a total of 26 patients were included in the present study. Six patients (23.1%) exhibited a partial response (PR), 13 (50%) achieved stable disease (SD) and 7 (26.9%) had progressive disease (PD) during the chemotherapy and gefitinib treatment. The disease control rate (DCR) was 73.1% and the median progression‑free survival (PFS) was 4.6 months [95% confidence interval (CI): 3.8‑5.4]. The toxicities associated with gefitinib and chemotherapy were generally acceptable. In conclusion, continued concurrent gefitinib and chemotherapy may be a valuable strategy, with acceptable and well‑tolerated toxicity. However, this treatment requires further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Song Z and Zhang Y: Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib. Mol Clin Oncol 1: 875-878, 2013.
APA
Song, Z., & Zhang, Y. (2013). Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib. Molecular and Clinical Oncology, 1, 875-878. https://doi.org/10.3892/mco.2013.156
MLA
Song, Z., Zhang, Y."Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib". Molecular and Clinical Oncology 1.5 (2013): 875-878.
Chicago
Song, Z., Zhang, Y."Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib". Molecular and Clinical Oncology 1, no. 5 (2013): 875-878. https://doi.org/10.3892/mco.2013.156
Copy and paste a formatted citation
x
Spandidos Publications style
Song Z and Zhang Y: Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib. Mol Clin Oncol 1: 875-878, 2013.
APA
Song, Z., & Zhang, Y. (2013). Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib. Molecular and Clinical Oncology, 1, 875-878. https://doi.org/10.3892/mco.2013.156
MLA
Song, Z., Zhang, Y."Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib". Molecular and Clinical Oncology 1.5 (2013): 875-878.
Chicago
Song, Z., Zhang, Y."Efficacy of chemotherapy plus gefitinib treatment in advanced non‑small‑cell lung cancer patients following acquired resistance to gefitinib". Molecular and Clinical Oncology 1, no. 5 (2013): 875-878. https://doi.org/10.3892/mco.2013.156
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