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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies

  • Authors:
    • Yi-Shan Wang
    • Guiqing Yang
    • Yuan-Yuan Wang
    • Jia-Lin Yang
    • Ke Yang
  • View Affiliations / Copyright

    Affiliations: Center for Tumor Treatment, People's Liberation Army 107th Hospital, Yantai, Shandong 264003, P.R. China
  • Pages: 925-929
    |
    Published online on: July 23, 2013
       https://doi.org/10.3892/mco.2013.157
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Abstract

Stereotactic body radiation therapy (SBRT) concentrates radiation to a predefined target, affecting all the cells within it. Adoptive immunotherapy is not restricted by the major histocompatibility complex (MHC) in recognizing and eliminating target cells. We investigated the effects of the combined modality of SBRT and adoptive immunotherapy on patients with advanced malignant tumors. the database of 316 patients with 845 tumors who underwent SBRT between April, 2010 and February, 2012 was retrospectively reviewed. Of the 316 patients, 145 received biological immunotherapy and were assigned into the observation group, whereas the remaining patients constituted the control group. Patients in the two groups were recorded on efficacy assessment, Karnofsky performance status (KPS), cell phenotype expression level in vitro and the percentages of lymphocyte subsets and ratio of CD4+̸CD8+ lymphocytes in the peripheral blood. Following treatment, the total effectiveness [complete response (CR) + partial response (PR)], the KPS score, the percentages of lymphocyte subsets and the CD4+̸CD8+ lymphocyte ratio in the observation group were higher compared to those in the control group, with a statistically significant difference (P<0.05). The expression of CD3+ and CD3+CD56+ cytokine‑induced killer (CIK) cells were increased from 56.76±4.54% and 11.32±2.96% to 94.67±4.46% and 32.65±1.12%, respectively, when cultured in vitro (P<0.01). The percentages of lymphocyte subsets and the CD4+̸CD8+ lymphocyte ratio were significantly increased compared to prior to treatment in the observation group (P<0.05). SBRT combined with adoptive immunotherapy may be a novel therapeutic option for patients with advanced malignant tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Yang G, Wang Y, Yang J and Yang K: Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies. Mol Clin Oncol 1: 925-929, 2013.
APA
Wang, Y., Yang, G., Wang, Y., Yang, J., & Yang, K. (2013). Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies. Molecular and Clinical Oncology, 1, 925-929. https://doi.org/10.3892/mco.2013.157
MLA
Wang, Y., Yang, G., Wang, Y., Yang, J., Yang, K."Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies". Molecular and Clinical Oncology 1.5 (2013): 925-929.
Chicago
Wang, Y., Yang, G., Wang, Y., Yang, J., Yang, K."Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies". Molecular and Clinical Oncology 1, no. 5 (2013): 925-929. https://doi.org/10.3892/mco.2013.157
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Yang G, Wang Y, Yang J and Yang K: Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies. Mol Clin Oncol 1: 925-929, 2013.
APA
Wang, Y., Yang, G., Wang, Y., Yang, J., & Yang, K. (2013). Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies. Molecular and Clinical Oncology, 1, 925-929. https://doi.org/10.3892/mco.2013.157
MLA
Wang, Y., Yang, G., Wang, Y., Yang, J., Yang, K."Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies". Molecular and Clinical Oncology 1.5 (2013): 925-929.
Chicago
Wang, Y., Yang, G., Wang, Y., Yang, J., Yang, K."Early efficacy of stereotactic body radiation therapy combined with adoptive immunotherapy for advanced malignancies". Molecular and Clinical Oncology 1, no. 5 (2013): 925-929. https://doi.org/10.3892/mco.2013.157
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