Regression of eosinophil counts after diagnosis of chronic graft-versus-host disease as a potential marker for improved clinical outcome

Beier,Fabian; Arbter,Klaus; Kittan,Nicolai  A.; Andreesen,Reinhard; Krause,Stefan  W.; Holler,Ernst; Hildebrandt,Gerhard  C.

doi:10.3892/mco.2013.192

January-February 2014 Volume 2 Issue 1

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January-February 2014 Volume 2 Issue 1

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Article

Regression of eosinophil counts after diagnosis of chronic graft-versus-host disease as a potential marker for improved clinical outcome

Authors:
- Fabian Beier
- Klaus Arbter
- Nicolai A. Kittan
- Reinhard Andreesen
- Stefan W. Krause
- Ernst Holler
- Gerhard C. Hildebrandt
View Affiliations / Copyright

Affiliations: Department of Hematology and Oncology, University of Regensburg Medical Center, D-93053 Regensburg, Germany
Pages: 81-86
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Published online on: September 25, 2013

https://doi.org/10.3892/mco.2013.192
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Abstract

Eosinophilia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been associated with the development of acute and chronic graft-versus-host disease (cGVHD). However, a limited number of studies have investigated the course of eosinophil counts in relation to the onset of cGVHD. In this study, the course of relative eosinophil counts (RECs) was retrospectively analyzed in 64 patients who developed cGVHD following allogeneic HSCT in relation to overall survival (OS), relapse rate and clinical course of cGVHD. At onset of cGVHD, eosinophilia was observed in 45% of the patients and developed one week prior to cGVHD diagnosis. Furthermore, a trend towards improved OS in patients with eosinophilia was observed. Beneficial effects were most evident in patients who exhibited decreasing eosinophil counts one week after diagnosis of cGVHD. By contrast, an increase in or stable eosinophil counts one week after diagnosis were associated with significantly impaired OS and a significantly higher rate of later aggravation of cGVHD. Findings of this study suggested that the course of eosinophil counts may provide a useful parameter in the assessment of cGVHD development and activity allowing the potential identification of patient subpopulations with a good outcome and reduced cGVHD‑related mortality.

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1.	Rothenberg ME: Eosinophilia. N Engl J Med. 338:1592–1600. 1998. View Article : Google Scholar : PubMed/NCBI
2.	Akpek G, Zahurak ML, Piantadosi S, et al: Development of a prognostic model for grading chronic graft-versus-host disease. Blood. 97:1219–1226. 2001. View Article : Google Scholar : PubMed/NCBI
3.	Filipovich AH, Weisdorf D, Pavletic S, et al: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant. 11:945–956. 2005. View Article : Google Scholar
4.	Baird K and Pavletic SZ: Chronic graft versus host disease. Curr Opin Hematol. 13:426–435. 2006. View Article : Google Scholar : PubMed/NCBI
5.	Ferrara JL, Levine JE, Reddy P and Holler E: Graft-versus-host disease. Lancet. 373:1550–1561. 2009. View Article : Google Scholar : PubMed/NCBI
6.	Landfried K, Wolff D and Holler E: Pathophysiology and management of graft-versus-host disease in the era of reduced-intensity conditioning. Curr Opin Oncol. 21(Suppl 1): S39–S41. 2009. View Article : Google Scholar : PubMed/NCBI
7.	Ahmad I, Labbe AC, Chagnon M, et al: Incidence and prognostic value of eosinophilia in chronic graft-versus-host disease after nonmyeloablative hematopoietic cell transplantation. Biol Blood Marrow Transplant. 17:1673–1678. 2011. View Article : Google Scholar : PubMed/NCBI
8.	Aisa Y, Mori T, Nakazato T, et al: Blood eosinophilia as a marker of favorable outcome after allogeneic stem cell transplantation. Transpl Int. 20:761–770. 2007. View Article : Google Scholar : PubMed/NCBI
9.	Arslan O, Akan H, Koc H, et al: Eosinophilia after allogeneic bone marrow transplantation using busulfan and cyclophosphamide conditioning regimen. Bone Marrow Transplant. 18:2611996.PubMed/NCBI
10.	Basara N, Kiehl MG and Fauser AA: Eosinophilia indicates the evolution to acute graft-versus-host disease. Blood. 100:30552002. View Article : Google Scholar : PubMed/NCBI
11.	Imahashi N, Miyamura K, Seto A, et al: Eosinophilia predicts better overall survival after acute graft-versus-host-disease. Bone Marrow Transplant. 45:371–377. 2010. View Article : Google Scholar : PubMed/NCBI
12.	Jacobsohn DA, Schechter T, Seshadri R, Thormann K, Duerst R and Kletzel M: Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children. Transplantation. 77:1096–1100. 2004. View Article : Google Scholar : PubMed/NCBI
13.	Kalaycioglu ME and Bolwell BJ: Eosinophilia after allogeneic bone marrow transplantation using the busulfan and cyclophosphamide preparative regimen. Bone Marrow Transplant. 14:113–115. 1994.PubMed/NCBI
14.	Kim DH, Popradi G, Xu W, et al: Peripheral blood eosinophilia has a favorable prognostic impact on transplant outcomes after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant. 15:471–482. 2009. View Article : Google Scholar : PubMed/NCBI
15.	McNeel D, Rubio MT, Damaj G, et al: Hypereosinophilia as a presenting sign of acute graft-versus-host disease after allogeneic bone marrow transplantation. Transplantation. 74:1797–1800. 2002. View Article : Google Scholar : PubMed/NCBI
16.	Przepiorka D, Anderlini P, Saliba R, et al: Chronic graft-versus-host disease after allogeneic blood stem cell transplantation. Blood. 98:1695–1700. 2001. View Article : Google Scholar : PubMed/NCBI
17.	Sato T, Kobayashi R, Nakajima M, Iguchi A and Ariga T: Significance of eosinophilia after stem cell transplantation as a possible prognostic marker for favorable outcome. Bone Marrow Transplant. 36:985–991. 2005. View Article : Google Scholar : PubMed/NCBI
18.	Alegre ML, Florquin S and Goldman M: Cellular mechanisms underlying acute graft rejection: time for reassessment. Curr Opin Immunol. 19:563–568. 2007. View Article : Google Scholar : PubMed/NCBI
19.	Nagral A, Ben-Ari Z, Dhillon AP and Burroughs AK: Eosinophils in acute cellular rejection in liver allografts. Liver Transpl Surg. 4:355–362. 1998. View Article : Google Scholar : PubMed/NCBI
20.	Foster PF, Sankary HN, Hart M, Ashmann M and Williams JW: Blood and graft eosinophilia as predictors of rejection in human liver transplantation. Transplantation. 47:72–74. 1989. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Regression of eosinophil counts after diagnosis of chronic graft-versus-host disease as a potential marker for improved clinical outcome

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