A retrospective clinicopathological analysis of small‑cell carcinoma of the uterine cervix

Dongol,Samina; Tai,YanHong; Shao,Yi; Jiang,Jie; Kong,Beihua

doi:10.3892/mco.2013.193

A retrospective clinicopathological analysis of small‑cell carcinoma of the uterine cervix

Authors:
- Samina Dongol
- YanHong Tai
- Yi Shao
- Jie Jiang
- Beihua Kong
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Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China, Jinan Military Area General Hospital, Jinan, Shandong, P.R. China, Shandong University School of Medicine, Jinan, Shandong, P.R. China
Published online on: September 25, 2013 https://doi.org/10.3892/mco.2013.193
Pages: 71-75

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Abstract

Cervical cancer encompasses several histological types, including neuroendocrine tumors (NETs). Small‑cell carcinoma of the uterine cervix (SCCC) is the most common and aggressive subtype of cervical NET. The objective of this case report was to investigate SCCC using a retrospective clinicopathological approach. Four cases of large (≥4 cm) SCCCs are presented in this case study. The patients were diagnosed with SCCC through a sequential hierarchy of physical examinations, laboratory reports, radiological reports, immunohistochemical and pathological tests. The diagnosis for each case was made at various stages (Ib1, Ib2, IIa2 and IIb, according to the FIGO staging system, 2000) and each of the patients received different multimodality therapeutic regimens. All the patients underwent radical hysterectomy and pelvic lymphadenectomy, followed by adjuvant chemotherapy. Neoadjuvant chemotherapy was administered prior to surgery in two of the patients. The clinical and pathological analyses were assessed using a retrospective measure, maintaining timely follow‑ups. SCCC is a rare but serious gynecological malignancy. This condition has a poor prognosis due to its high aggressiveness, high rate of metastases and mortality. Furthermore, the rarity of this disease represents a hindrance to adequate research and development of novel, efficient therapeutic regimens.

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1.	Albores-Saavedra J, Gersell D, Gilks CB, et al: Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the college of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med. 121:34–39. 1997.
2.	Chan JK, Loizzi V, Burger RA, Rutgers J and Monk BJ: Prognostic factors in neuroendocrine small cell cervical carcinoma, a multivariate analysis. Cancer. 97:568–574. 2003. View Article : Google Scholar : PubMed/NCBI
3.	Nasu K, Hirakawa T, Okamoto M, Nishida M, Kiyoshima C, Matsumoto H, Takai N and Narahara H: Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery. Rare Tumors. 3:e62011. View Article : Google Scholar : PubMed/NCBI
4.	Sheets EE, Berman ML, Hrountas CK, et al: Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma. Obstet Gynecol. 71:10–14. 1988.PubMed/NCBI
5.	Reagan JW, Hamonic MJ and Wentz WB: Analytical study of the cells in cervical squamous-cell cancer. Lab Invest. 6:241–250. 1957.PubMed/NCBI
6.	Boruta DM 2nd, Schorge JO, Duska LA, Crum CP, Castrillon DH and Sheets EE: Multimodality therapy in early-stage neuroendocrine carcinoma of the uterine cervix. Gynecol Oncol. 81:82–87. 2001. View Article : Google Scholar : PubMed/NCBI
7.	Barrett RJ 2nd, Davos I, Leuchter RS and Lagasse LD: Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix. Cancer. 60:2325–2330. 1987. View Article : Google Scholar : PubMed/NCBI
8.	Chang TC, Lai CH, Tseng CJ, Hsueh S, Huang KG and Chou HH: Prognostic factors in surgically treated small cell cervical carcinoma followed by adjuvant chemotherapy. Cancer. 83:712–718. 1998. View Article : Google Scholar : PubMed/NCBI
9.	Gilks CB, Young RH, Gersell DJ and Clement PB: Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic study of 12 cases. Am J Surg Pathol. 21:905–914. 1997. View Article : Google Scholar : PubMed/NCBI
10.	Giorgaze T, Kanhere R, Pang C, Ganote C, Miller LE, Tabaczka P, Brown E and Husain M: Small cell carcinoma of the cervix in liquid-based Pap test: utilization of split-sample immunocyto-chemical and molecular analysis. Diagn Cytopathol. 40:214–219. 2012. View Article : Google Scholar : PubMed/NCBI
11.	Wang HL and Lu DW: Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix. Mod Pathol. 17:732–738. 2004. View Article : Google Scholar : PubMed/NCBI
12.	Sukpan K, Settakorn J, Khunamornpong S, Cheewakriangkrai C, Srisomboon J and Siriaunkgul S: Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix. Int J Gynecol Cancer. 21:911–917. 2011. View Article : Google Scholar : PubMed/NCBI
13.	Dueñas-Gonzalez A, López-Graniel C, González-Enciso A, Cetina L, Rivera L, Mariscal I, Montalvo G, Gómez E, de la Garza J, Chanona G and Mohar A: A phase II study of multimodality treatment for locally advanced cervical cancer: neoadjuvant carboplatin and paclitaxel followed by radical hysterectomy and adjuvant cisplatin chemoradiation. Ann Oncol. 14:1278–1284. 2003.
14.	Bermudez A, Vighi S, Garcia A and Sardi J: Neuroendocrine cervical carcinoma: a diagnostic and therapeutic challenge. Gynecol Oncol. 82:32–39. 2001. View Article : Google Scholar : PubMed/NCBI
15.	Pazdur R, Bonomi P, Slayton R, et al: Neuroendocrine carcinoma of the cervix: implications for staging and therapy. Gynecol Oncol. 12:120–128. 1981. View Article : Google Scholar : PubMed/NCBI
16.	Hoskins PJ, Swenerton KD, Pike JA, et al: Small-cell carcinoma of the cervix: fourteen years of experience at a single institution using a combined-modality regimen of involved-field irradiation and platinum-based combination chemotherapy. J Clin Oncol. 21:3495–3501. 2003.
17.	Zivanovic O, Leitao MM Jr, Park KJ, et al: Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy. Gynecol Oncol. 112:590–593. 2009. View Article : Google Scholar : PubMed/NCBI
18.	Futagami M, Yokoyama Y and Mizunuma H: Presentation of a patient with pT2bN1M0 small cell carcinoma of the uterine cervix who obtained long-term survival with maintenance chemotherapy, and literature-based discussion. Eur J Gynaecol Oncol. 32:99–102. 2011.PubMed/NCBI
19.	Embry JR, Kelly MG, Post MD and Spillman MA: Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy. Gynecol Oncol. 120:444–448. 2011. View Article : Google Scholar : PubMed/NCBI
20.	Siriaunkgul S, Utaipat U, Settakorn J, Sukpan K, Srisomboon J and Khunamornpong S: HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand. Int J Gynaecol Obstet. 115:175–179. 2011. View Article : Google Scholar : PubMed/NCBI
21.	Bian LH, Wang XL, Guo YF, Wu XZ, Song L and Liu HT: Study of human papillomavirus in small cell neuroendocrine carcinoma of the uterine cervix. Chin J Exp Clin Virol. 25:63–65. 2011.(In Chinese).
22.	Rashed MM and Bekele A: Neuroendocrine differentiation in a case of cervical cancer. Pan Afr Med J. 6:42010.
23.	Conner MG, Richter H, Moran CA, Hameed A and Albores-Saavedra J: Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 6:345–348. 2002. View Article : Google Scholar : PubMed/NCBI
24.	Deng GH, Zhang X and Wu LY: Clinicopathological analysis of nine cases of small cell carcinoma of the uterine cervix. Chin J Oncol. 32:199–202. 2010.(In Chinese).
25.	Cohen JG, Kapp DS, Shin JY, Urban R, Sherman AE, Chen LM, Osann K and Chan JK: Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients. Am J Obstet Gynecol. 203:3472010. View Article : Google Scholar : PubMed/NCBI
26.	Horn LC, Fischer U and Bilek K: Neuroendocrine differentiated carcinoma of the uterine cervix. Zentralbl Gynakol. 118:679–683. 1996.(In German).