Endobronchial ultrasound guided‑transbronchial needle aspiration vs. conventional transbronchial needle aspiration in the diagnosis of mediastinal masses: A meta‑analysis

Zhu,Tianyi; Zhang,Xinji; Xu,Junnan; Tian,Jun; Li,Hui; Liu,Dan; Chen,Ruohua; Li,Qiang; Bai,Chong

doi:10.3892/mco.2013.206

January-February 2014 Volume 2 Issue 1

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January-February 2014 Volume 2 Issue 1

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Article

Endobronchial ultrasound guided‑transbronchial needle aspiration vs. conventional transbronchial needle aspiration in the diagnosis of mediastinal masses: A meta‑analysis

Authors:
- Tianyi Zhu
- Xinji Zhang
- Junnan Xu
- Jun Tian
- Hui Li
- Dan Liu
- Ruohua Chen
- Qiang Li
- Chong Bai
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Affiliations: Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China, Department of Health Statistics, Second Military Medical University, Shanghai, P.R. China, Department of Pathophysiology, Second Military Medical University, Shanghai, P.R. China, Department of Immunology, Zhejiang University, Hangzhou, Zhejiang, P.R. China
Pages: 151-155
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Published online on: October 23, 2013

https://doi.org/10.3892/mco.2013.206
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Abstract

Whether an endobronchial ultrasound (EBUS) is required for transbronchial needle aspiration (TBNA) in the diagnosis of mediastinal masses is currently a disputed subject. Previous studies have demonstrated that EBUS‑TBNA performs better compared to conventional TBNA as it is capable of sampling in real-time compared with conventional TBNA. However, some clinicians consider conventional TBNA to be sufficient for diagnosis. In this meta‑analysis, we evaluated these two methods according to diagnostic yield. A search was conducted through PubMed, Embase and the proceedings of major conferences, for studies comparing TBNA with EBUS‑TBNA in the diagnosis of mediastinal masses. The identified studies were evaluated for publication bias and heterogeneity. The primary outcome was diagnostic yield. Pooled odds ratio (OR) estimated with 95% confidence intervals (CIs) was calculated using the fixed‑effects model. Five studies, including a total of 407 patients, were included in the meta‑analysis. The EBUS‑TBNA arm was associated with a significantly higher OR compared to that of the TBNA arm in terms of diagnostic yield (OR=2.72, 95% CI: 1.72‑4.30, P<0.001). There was no evidence of heterogeneity (I2=0%, P=0.540) or publication bias (Egger's test, P=0.568; Begg‑Mazumdar test, P=0.806). In conclusion, EBUS‑TBNA and conventional TBNA are safe and provide good diagnostic yield in the diagnosis of hilar and mediastinal masses and lymphadenopathies; however, EBUS‑TBNA performs better compared to conventional TBNA, with a shorter aspiration time and higher sensitivity.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Endobronchial ultrasound guided‑transbronchial needle aspiration vs. conventional transbronchial needle aspiration in the diagnosis of mediastinal masses: A meta‑analysis

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