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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer

  • Authors:
    • Xiaojiao Guan
    • Xinwen Zhong
    • Wanfu Men
    • Shulei Gong
    • Lin Zhang
    • Yuchen Han
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Basic Science College, China Medical University, Shenyang, Liaoning, P.R. China, Department of Thoracic Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, P.R. China
  • Pages: 76-80
    |
    Published online on: October 24, 2013
       https://doi.org/10.3892/mco.2013.207
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy, requiring effective biomarkers for prognosis and therapeutic responsiveness. Histone H3K9 methyltransferases (EHMT1 and EHMT2) are global genome organizers, which are crucial for maintaining the balance state of cells in a tissue‑specific manner. It was previously suggested that EHMT1 expression is a predictor of prognosis in several malignant tumors; however, the prognostic significance of EHMT1 expression in ESCC has not been determined. A cohort of 50 ESCC cases and 46 paired normal esophageal tissue samples were evaluated to assess the levels of EHMT1 expression by immunohistochemistry and reverse transcription‑polymerase chain reaction. the SPSS software package was used for statistical data analysis. A significantly upregulated EHMT1 expression was observed in squamous preinvasive lesions and ESCC compared to the matched normal esophageal epithelia (52.0 vs. 21.7%, respectively). The expression of EHMT1 was correlated with tumor grade (G), depth of invasion (T) and lymph node metastasis (N) in ESCC. EHMT1 overexpression was found to be associated with poor cancer‑specific survival in squamous cell carcinomas (χ2=3.922, P=0.048). The expression of EHMT1 was identified as an independent prognostic factor for overall survival in ESCC patients. In conclusion, EHMT1 expression is upregulated in ESCC and early preinvasive esophageal squamous lesions and the overexpression of EHMT1 is associated with poor prognosis in ESCC. Therefore, the expression of EHMT1 may be an effective prognostic biomarker for ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Guan X, Zhong X, Men W, Gong S, Zhang L and Han Y: Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Mol Clin Oncol 2: 76-80, 2014.
APA
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., & Han, Y. (2014). Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Molecular and Clinical Oncology, 2, 76-80. https://doi.org/10.3892/mco.2013.207
MLA
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., Han, Y."Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer". Molecular and Clinical Oncology 2.1 (2014): 76-80.
Chicago
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., Han, Y."Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer". Molecular and Clinical Oncology 2, no. 1 (2014): 76-80. https://doi.org/10.3892/mco.2013.207
Copy and paste a formatted citation
x
Spandidos Publications style
Guan X, Zhong X, Men W, Gong S, Zhang L and Han Y: Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Mol Clin Oncol 2: 76-80, 2014.
APA
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., & Han, Y. (2014). Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer. Molecular and Clinical Oncology, 2, 76-80. https://doi.org/10.3892/mco.2013.207
MLA
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., Han, Y."Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer". Molecular and Clinical Oncology 2.1 (2014): 76-80.
Chicago
Guan, X., Zhong, X., Men, W., Gong, S., Zhang, L., Han, Y."Analysis of EHMT1 expression and its correlations with clinical significance in esophageal squamous cell cancer". Molecular and Clinical Oncology 2, no. 1 (2014): 76-80. https://doi.org/10.3892/mco.2013.207
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