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Article

Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma

  • Authors:
    • Zhanmeng Zhu
    • Zhe Chen
    • Chunlin Chen
    • Ziyi Yang
    • Weibo Xuan
    • Yahui Hou
    • Yunfei Zuo
    • Shuangyi Ren
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China, Department of Clinical Biochemistry, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
  • Pages: 139-145
    |
    Published online on: October 29, 2013
       https://doi.org/10.3892/mco.2013.208
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Abstract

The aim of this study was to investigate tumor biomarker carbohydrate antigen 724 (CA724) in the serum of patients with carcinomas of the colon and rectum at various clinical stages. Serum was collected from 51 patients with colon carcinoma (CC) and 49 patients with rectal carcinoma (RC). CA724 levels were then measured in the different groups according to site, TNM classification, gender, age and metastastic status of the patients. The statistical significance of the differences between the groups was calculated by non‑parametric statistics (Mann‑Whitney and Kruskall‑Wallis tests). We observed a close association between the serum CA724 levels and tumor migration in colorectal carcinoma (CRC) and opposite variation tendencies of CA724 in the evolution of CC and RC. In conclusion, we identified a close association between the serum levels of CA724 and tumor migration in CRC. The opposite variation tendencies of CA724 in the different evolution groups of CC and RC may reflect the differences between these two types of cancer. The evaluation of serum CA724 may be of monitoring and and predictive value and may also assist in the development of treatment strategies for CRC patients.
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1. 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar

2. 

Sung JJ, Lau JY, Goh KL, et al: Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 6:871–876. 2005. View Article : Google Scholar : PubMed/NCBI

3. 

Hofstad B and Vatn M: Growth rate of colon polyps and cancer. Gastrointest Endosc Clin N Am. 7:345–363. 1997.PubMed/NCBI

4. 

Winawer SJ, Fletcher RH, Miller L, et al: Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology. 112:594–642. 1997. View Article : Google Scholar : PubMed/NCBI

5. 

Wong JJ, Hawkins NJ and Ward RL: Colorectal cancer: a model for epigenetic tumorigenesis. Gut. 56:140–148. 2007. View Article : Google Scholar : PubMed/NCBI

6. 

Diallo Owono FK, Nguema Mve R, Ibaba J, Mihindou C and Ondo N’dong F: Epidemiological and diagnostic features of colorectal cancer in Libreville, Gabon. Med Trop (Mars). 71:605–607. 2011.(In French).

7. 

U.S. Preventive Services Task Force: Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 149:627–637. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Levin B, Lieberman DA, McFarland B, et al American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin. 58:130–160. 2008. View Article : Google Scholar

9. 

Dominic OG, McGarrity T, Dignan M and Lengerich EJ: American College of Gastroenterology Guidelines for Colorectal Cancer Screening 2008. Am J Gastroenterol. 104:2626–2627; author reply 2628–2629. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Lumachi F, Marino F, Orlando R, Chiara GB and Basso SM: Simultaneous multianalyte immunoassay measurement of five serum tumor markers in the detection of colorectal cancer. Anticancer Res. 32:985–988. 2012.PubMed/NCBI

11. 

Wang JY, Lu CY, Chu KS, et al: Prognostic significance of pre- and postoperative serum carcinoembryonic antigen levels in patients with colorectal cancer. Eur Surg Res. 39:245–250. 2007. View Article : Google Scholar : PubMed/NCBI

12. 

Chen XZ, Zhang WK, Yang K, et al: Correlation between serum CA724 and gastric cancer: multiple analyses based on Chinese population. Mol Biol Rep. 39:9031–9039. 2012. View Article : Google Scholar : PubMed/NCBI

13. 

Nicolini A, Ferrari P, Duffy MJ, et al: Intensive risk-adjusted follow-up with the CEA, TPA, CA19.9, and CA72.4 tumor marker panel and abdominal ultrasonography to diagnose operable colorectal cancer recurrences: effect on survival. Arch Surg. 145:1177–1183. 2010. View Article : Google Scholar

14. 

Li M, Li JY, Zhao AL and Gu J: Colorectal cancer or colon and rectal cancer? Clinicopathological comparison between colonic and rectal carcinomas. Oncology. 73:52–57. 2007. View Article : Google Scholar

15. 

Filella X, Molina R, Mengual PJ, et al: Significance of CA72.4 in patients with colorectal cancer. Comparison with CEA and CA19.9. J Nucl Biol Med. 35:158–161. 1991.PubMed/NCBI

16. 

Yu JK, Yang MQ, Jiang TJ and Zheng S: The optimal combination of serum tumor markers with bioinformatics in diagnosis of colorectal carcinoma. J Zhejiang Univ. 33:407–410. 2004.(In Chinese).

17. 

Newton KF, Newman W and Hill J: Review of biomarkers in colorectal cancer. Colorectal Dis. 14:3–17. 2012. View Article : Google Scholar

18. 

Wiggers T, Arends JW, Verstijnen C, et al: Prognostic significance of CEA immunoreactivity patterns in large bowel carcinoma tissue. Br J Cancer. 54:409–414. 1986. View Article : Google Scholar : PubMed/NCBI

19. 

Kitadai Y, Radinsky R, Bucana CD, et al: Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment. Am J Pathol. 149:1157–1166. 1996.PubMed/NCBI

20. 

Seregni E, Ferrari L, Martinetti A and Bombardieri E: Diagnostic and prognostic tumor markers in the gastrointestinal tract. Semin Surg Oncol. 20:147–166. 2001. View Article : Google Scholar : PubMed/NCBI

21. 

Araki K, Furuya Y, Kobayashi M, et al: Comparison of mucosal microvasculature between the proximal and distal human colon. J Electron Microsc (Tokyo). 45:202–206. 1996. View Article : Google Scholar : PubMed/NCBI

22. 

Skinner SA and O’Brien PE: The microvascular structure of the normal colon in rats and humans. J Surg Res. 61:482–490. 1996. View Article : Google Scholar : PubMed/NCBI

23. 

Devesa SS and Chow WH: Variation in colorectal cancer incidence in the United States by subsite of origin. Cancer. 71:3819–3826. 1993. View Article : Google Scholar : PubMed/NCBI

24. 

Shamsuddin AM, Phelps PC and Trump BF: Human large intestinal epithelium: light microscopy, histochemistry, and ultrastructure. Hum Pathol. 13:790–803. 1982. View Article : Google Scholar : PubMed/NCBI

25. 

Macfarlane GT, Gibson GR and Cummings JH: Comparison of fermentation reactions in different regions of the human colon. J Appl Bacteriol. 72:57–64. 1992.PubMed/NCBI

26. 

Mercurio MG, Shiff SJ, Galbraith RA and Sassa S: Expression of cytochrome P450 mRNAs in the colon and the rectum in normal human subjects. Biochem Biophys Res Commun. 210:350–355. 1995. View Article : Google Scholar : PubMed/NCBI

27. 

Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Z, Chen Z, Chen C, Yang Z, Xuan W, Hou Y, Zuo Y and Ren S: Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Mol Clin Oncol 2: 139-145, 2014.
APA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y. ... Ren, S. (2014). Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Molecular and Clinical Oncology, 2, 139-145. https://doi.org/10.3892/mco.2013.208
MLA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2.1 (2014): 139-145.
Chicago
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2, no. 1 (2014): 139-145. https://doi.org/10.3892/mco.2013.208
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Z, Chen Z, Chen C, Yang Z, Xuan W, Hou Y, Zuo Y and Ren S: Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Mol Clin Oncol 2: 139-145, 2014.
APA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y. ... Ren, S. (2014). Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma. Molecular and Clinical Oncology, 2, 139-145. https://doi.org/10.3892/mco.2013.208
MLA
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2.1 (2014): 139-145.
Chicago
Zhu, Z., Chen, Z., Chen, C., Yang, Z., Xuan, W., Hou, Y., Zuo, Y., Ren, S."Opposite variation tendencies of serum CA724 levels in patients with colon and rectal carcinoma". Molecular and Clinical Oncology 2, no. 1 (2014): 139-145. https://doi.org/10.3892/mco.2013.208
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