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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials

  • Authors:
    • Guodong Shen
    • Geng Bian
    • Haiying Yu
    • Min Gao
    • Dongmei Kang
    • Gan Shen
    • Shilian Hu
  • View Affiliations / Copyright

    Affiliations: Geriatrics Department, Anhui Provincial Hospital, Hefei, Anhui 230001, P.R. China, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei, Anhui 230001, P.R. China
  • Pages: 146-150
    |
    Published online on: November 6, 2013
       https://doi.org/10.3892/mco.2013.210
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Abstract

Whether cisplatin plus vinorelbine (VC) or cisplatin plus docetaxel (DC) are equally effective in the treatment of advanced non‑small‑cell lung cancer (NSCLC) remains controversial. The aim of this study was to compare the VC and DC regimens in the first‑line treatment of advanced NSCLC. A search was conducted through PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE and the Chinese Biomedical Literature database (CBM). The language of the publication was not considered to be a limitation. The recruited trials were evaluated for eligibility and quality and the data were extracted and analyzed. The endpoints were overall response, survival rate and toxicity. We analyzed 9 randomized controlled trials (RCTs), including a total of 1,886 patients. Patients receiving DC therapy exhibited a significantly higher response rate [relative risk (RR)=0.83, 95% CI: 0.73‑0.95 and P=0.007] and 2‑year survival rate (RR=0.65, 95% CI: 0.50‑0.84 and P=0.001). However, the 1‑year survival rate for the two cisplatin‑based regimens were comparable (RR=0.90, 95% CI: 0.81‑1.01 and P=0.07). Patients receiving the VC regimen more frequently developed grade 3̸4 leucopenia, anemia and vomiting, whereas those receiving DC chemotherapy were more prone to grade 3̸4 diarrhea. The incidence of grade 3̸4 neutropenia, thrombocytopenia and nausea were similar between the two arms. In conclusion, our study indicated that DC is superior to the VC regimen in terms of tumor response rate, 2‑year survival rate and safety for the first‑line treatment of advanced NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Shen G, Bian G, Yu H, Gao M, Kang D, Shen G and Hu S: Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials. Mol Clin Oncol 2: 146-150, 2014.
APA
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., & Hu, S. (2014). Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials. Molecular and Clinical Oncology, 2, 146-150. https://doi.org/10.3892/mco.2013.210
MLA
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., Hu, S."Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials". Molecular and Clinical Oncology 2.1 (2014): 146-150.
Chicago
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., Hu, S."Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials". Molecular and Clinical Oncology 2, no. 1 (2014): 146-150. https://doi.org/10.3892/mco.2013.210
Copy and paste a formatted citation
x
Spandidos Publications style
Shen G, Bian G, Yu H, Gao M, Kang D, Shen G and Hu S: Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials. Mol Clin Oncol 2: 146-150, 2014.
APA
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., & Hu, S. (2014). Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials. Molecular and Clinical Oncology, 2, 146-150. https://doi.org/10.3892/mco.2013.210
MLA
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., Hu, S."Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials". Molecular and Clinical Oncology 2.1 (2014): 146-150.
Chicago
Shen, G., Bian, G., Yu, H., Gao, M., Kang, D., Shen, G., Hu, S."Comparison between cisplatin plus vinorelbine and cisplatin plus docetaxel in the treatment of advanced non‑small‑cell lung cancer: A meta‑analysis of randomized controlled trials". Molecular and Clinical Oncology 2, no. 1 (2014): 146-150. https://doi.org/10.3892/mco.2013.210
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