Usefulness of magnifying endoscopy with narrow-band imaging for diagnosis of depressed gastric lesions

Sumie,Hiroaki; Sumie,Shuji; Nakahara,Keita; Watanabe,Yasutomo; Matsuo,Ken; Mukasa,Michita; Sakai,Takeshi; Yoshida,Hikaru; Tsuruta,Osamu; Sata,Michio

doi:10.3892/mco.2013.213

January-February 2014 Volume 2 Issue 1

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January-February 2014 Volume 2 Issue 1

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Article

Usefulness of magnifying endoscopy with narrow-band imaging for diagnosis of depressed gastric lesions

Authors:
- Hiroaki Sumie
- Shuji Sumie
- Keita Nakahara
- Yasutomo Watanabe
- Ken Matsuo
- Michita Mukasa
- Takeshi Sakai
- Hikaru Yoshida
- Osamu Tsuruta
- Michio Sata
View Affiliations / Copyright

Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Prevention Center for Adult Diseases, Saga Medical Association, Saga, Saga 849-0942, Japan, Saiseikai Futsukaichi Hospital, Chikushino, Fukuoka 818-8516, Japan
Pages: 129-133
|
Published online on: November 13, 2013

https://doi.org/10.3892/mco.2013.213
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Abstract

The usefulness of magnifying endoscopy with narrow‑band imaging (ME-NBI) for the diagnosis of early gastric cancer is well known, however, there are no evaluation criteria. The aim of this study was to devise and evaluate a novel diagnostic algorithm for ME-NBI in depressed early gastric cancer. Between August, 2007 and May, 2011, 90 patients with a total of 110 depressed gastric lesions were enrolled in the study. A diagnostic algorithm was devised based on ME-NBI microvascular findings: microvascular irregularity and abnormal microvascular patterns (fine network, corkscrew and unclassified patterns). The diagnostic efficiency of the algorithm for gastric cancer and histological grade was assessed by measuring its mean sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy. Furthermore, inter- and intra-observer variation were measured. In the differential diagnosis of gastric cancer from non‑cancerous lesions, the mean sensitivity, specificity, PPV, NPV, and accuracy of the diagnostic algorithm were 86.7, 48.0, 94.4, 26.7, and 83.2%, respectively. Furthermore, in the differential diagnosis of undifferentiated adenocarcinoma from differentiated adenocarcinoma, the mean sensitivity, specificity, PPV, NPV, and accuracy of the diagnostic algorithm were 61.6, 86.3, 69.0, 84.8, and 79.1%, respectively. For the ME-NBI final diagnosis using this algorithm, the mean κ values for inter- and intra-observer agreement were 0.50 and 0.77, respectively. In conclusion, the diagnostic algorithm based on ME-NBI microvascular findings was convenient and had high diagnostic accuracy, reliability and reproducibility in the differential diagnosis of depressed gastric lesions.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Usefulness of magnifying endoscopy with narrow-band imaging for diagnosis of depressed gastric lesions

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