Adenosquamous cell lung cancer successfully treated with gefitinib: A case report

Kurishima,Koichi; Ohara,Gen; Kagohashi,Katsunori; Watanabe,Hiroko; Takayashiki,Norio; Ishibashi,Atsushi; Satoh,Hiroaki

doi:10.3892/mco.2013.221

March-April 2014 Volume 2 Issue 2

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March-April 2014 Volume 2 Issue 2

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Case Report

Adenosquamous cell lung cancer successfully treated with gefitinib: A case report

Authors:
- Koichi Kurishima
- Gen Ohara
- Katsunori Kagohashi
- Hiroko Watanabe
- Norio Takayashiki
- Atsushi Ishibashi
- Hiroaki Satoh
View Affiliations / Copyright

Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Pathology, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Surgery, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan
Pages: 282-284
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Published online on: December 9, 2013

https://doi.org/10.3892/mco.2013.221
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Abstract

Although adenosquamous cell lung cancer (ASCLC) is included in the non‑small‑cell lung cancers (NSCLCs), the number of currently available studies on the response of this type of cancer to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs) is limited. This is the case report of a 66‑year‑old female who was referred to the Mito Medical Center (Mito, Japan) with hemoptysis and the chest computed tomography (CT) scan revealed a large cavitary mass in the lower lobe of the left lung. The patient underwent surgical resection of the lesion and the final pathological diagnosis was ASCLC staged as pT2bN2M0. Notably, an EGFR exon 19 deletion was identified in the adenocarcinomatous as well as the squamous cell carcinomatous components of the tumor. Despite adjuvant chemotherapy, the patient developed small cavitary metastases in the lungs bilaterally. Therefore, treatment with gefitinib was initiated. The chest CT scan revealed substantial regression of the metastatic cavitary tumors in both lungs, with thinning of the walls. The patient remains alive and recurrence‑free 19 months following the initiation of gefitinib therapy. This case demonstrated an optimal clinical response to gefitinib treatment for EGFR mutation‑positive ASCLC, suggesting that gefitinib is a therapeutic option for such a subset of patients with ASCLC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Adenosquamous cell lung cancer successfully treated with gefitinib: A case report

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