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Article

Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation

  • Authors:
    • Masashi Hirooka
    • Hironori Ochi
    • Yohei Koizumi
    • Yoshio Tokumoto
    • Atsushi Hiraoka
    • Teru Kumagi
    • Masanori Abe
    • Hiroaki Tanaka
    • Yoichi Hiasa
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan, Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Ehime 790‑0024, Japan, Department of Radiology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan
  • Pages: 182-186
    |
    Published online on: December 20, 2013
       https://doi.org/10.3892/mco.2013.229
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. HCC is generally considered to spread via the bloodstream and local recurrence often occurs in the blood drainage area determined by computed tomography during hepatic arteriography (CTHA), despite complete ablation of the primary nodule. This study was conducted in order to prospectively assess the rate of local recurrence in the blood drainage area depicted by delayed‑phase CTHA. The participants comprised 364 consecutive patients (260 men and 104 women; mean age, 67.4±8.6 years), enrolled between April, 2002 and December, 2011. The participants were divided into two groups, according to whether the ablation area covered the entire blood drainage area as defined by delayed‑phase CTHA (group A) or not (group B). Local tumor progression was compared between the two groups. The median time to recurrence was significantly shorter for group B (434 days) compared to that for group A (1,474 days; P=0.0037). The cumulative local recurrence rates for group A were 0, 0 and 1.5% at 1, 3 and 5 years postoperatively, respectively, whereas the recurrence rates for group B were 3.8, 17.0 and 22.8% at 1, 3 and 5 years, respectively (P<0.0001). In conclusion, the safety margin for radiofrequency ablation should be defined as the blood drainage area and ablation should aim at acquiring adequate safety margins.
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Copy and paste a formatted citation
Spandidos Publications style
Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H and Hiasa Y: Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. Mol Clin Oncol 2: 182-186, 2014.
APA
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T. ... Hiasa, Y. (2014). Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. Molecular and Clinical Oncology, 2, 182-186. https://doi.org/10.3892/mco.2013.229
MLA
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T., Abe, M., Tanaka, H., Hiasa, Y."Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation". Molecular and Clinical Oncology 2.2 (2014): 182-186.
Chicago
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T., Abe, M., Tanaka, H., Hiasa, Y."Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation". Molecular and Clinical Oncology 2, no. 2 (2014): 182-186. https://doi.org/10.3892/mco.2013.229
Copy and paste a formatted citation
x
Spandidos Publications style
Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H and Hiasa Y: Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. Mol Clin Oncol 2: 182-186, 2014.
APA
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T. ... Hiasa, Y. (2014). Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. Molecular and Clinical Oncology, 2, 182-186. https://doi.org/10.3892/mco.2013.229
MLA
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T., Abe, M., Tanaka, H., Hiasa, Y."Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation". Molecular and Clinical Oncology 2.2 (2014): 182-186.
Chicago
Hirooka, M., Ochi, H., Koizumi, Y., Tokumoto, Y., Hiraoka, A., Kumagi, T., Abe, M., Tanaka, H., Hiasa, Y."Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation". Molecular and Clinical Oncology 2, no. 2 (2014): 182-186. https://doi.org/10.3892/mco.2013.229
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