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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-April 2013 Volume 1 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

XIAP expression is associated with pancreatic carcinoma outcome

  • Authors:
    • Shengmian Li
    • Jianjian Sun
    • Jian Yang
    • Lan Zhang
    • Le Wang
    • Xiaoling Wang
    • Zhanjun Guo
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 305-308
    |
    Published online on: January 2, 2013
       https://doi.org/10.3892/mco.2013.58
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Abstract

Pancreatic carcinoma is an aggressive tumor that is resistant to treatment regimens. Although the X-linked inhibitor of apoptosis protein (XIAP) overexpression in pancreatic carcinoma cells has been previously reported, the aim of this study was to investigate the association of XIAP expression with pancreatic carcinoma outcome. Specimens were obtained from 54 patients who underwent resection for pancreatic cancer. Kaplan-Meier survival analysis was used to estimate post-operative survival. The results of this analysis revealed a significantly shorter overall survival time in patients with a high compared to those with a low XIAP expression (P=0.041). Results of the multivariate analysis revealed that XIAP expression was identified as an independent predictor for pancreatic carcinoma outcome [relative risk, 1.771; 95% confidence interval (CI), 1.099-2.852; P=0.019]. Moreover, XIAP levels were associated with pancreatic carcinoma characteristics, including tumor invasion status and histological grade. XIAP overexpression shortens the survival of pancreatic cancer patients probably by modifying their resistance to apoptosis and the proliferation capacity of pancreatic carcinoma cells. Thus, XIAP expression analysis can help in the identification of patient subgroups at high risk of a poor disease outcome.
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Copy and paste a formatted citation
Spandidos Publications style
Li S, Sun J, Yang J, Zhang L, Wang L, Wang X and Guo Z: XIAP expression is associated with pancreatic carcinoma outcome. Mol Clin Oncol 1: 305-308, 2013.
APA
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., & Guo, Z. (2013). XIAP expression is associated with pancreatic carcinoma outcome. Molecular and Clinical Oncology, 1, 305-308. https://doi.org/10.3892/mco.2013.58
MLA
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., Guo, Z."XIAP expression is associated with pancreatic carcinoma outcome". Molecular and Clinical Oncology 1.2 (2013): 305-308.
Chicago
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., Guo, Z."XIAP expression is associated with pancreatic carcinoma outcome". Molecular and Clinical Oncology 1, no. 2 (2013): 305-308. https://doi.org/10.3892/mco.2013.58
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Sun J, Yang J, Zhang L, Wang L, Wang X and Guo Z: XIAP expression is associated with pancreatic carcinoma outcome. Mol Clin Oncol 1: 305-308, 2013.
APA
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., & Guo, Z. (2013). XIAP expression is associated with pancreatic carcinoma outcome. Molecular and Clinical Oncology, 1, 305-308. https://doi.org/10.3892/mco.2013.58
MLA
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., Guo, Z."XIAP expression is associated with pancreatic carcinoma outcome". Molecular and Clinical Oncology 1.2 (2013): 305-308.
Chicago
Li, S., Sun, J., Yang, J., Zhang, L., Wang, L., Wang, X., Guo, Z."XIAP expression is associated with pancreatic carcinoma outcome". Molecular and Clinical Oncology 1, no. 2 (2013): 305-308. https://doi.org/10.3892/mco.2013.58
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