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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-April 2013 Volume 1 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma

  • Authors:
    • Guang-Jun Zhang
    • Tong Zhou
    • Zuo-Liang Liu
    • Hong-Peng Tian
    • Shu-Sen Xia
  • View Affiliations / Copyright

    Affiliations: The First Department of General Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
  • Pages: 379-384
    |
    Published online on: January 7, 2013
       https://doi.org/10.3892/mco.2013.61
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Abstract

It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and are potentially disease‑specific. The aim of this study was to investigate whether plasma miR‑200c and miR‑18a can be used as biomarkers for the detection of colorectal carcinoma (CRC). This study was divided into three parts: i) confirmation of higher miR‑200c and miR‑18a levels in primary CRC tissues compared to normal colorectal tissues; ii) evaluation of plasma miR‑200c and miR‑18a expression by comparing 78 patients with 86 healthy volunteers and iii) comparison of miR‑200c and miR‑18a levels in paired pre-and post-operative plasma in cancer patients who underwent curative CRC resection. Results showed that the expression of miR‑200c and miR‑18a was significantly higher in CRC compared to normal tissues. The plasma levels of miR‑200c and miR‑18a were significantly higher in CRC patients compared to controls. miR‑200c yielded an area under the receiver‑operating characteristics (ROC) curve (AUC) of 0.749 and miR‑18a yielded an AUC of 0.804 when distinguishing CRC patients from the controls. Combined ROC analyses using the two miRNAs revealed an elevated AUC of 0.839 with 84.6% sensitivity and 75.6% specificity in discriminating CRC. Plasma levels of miR‑200c and miR‑18a were significantly lower in post‑operative compared to pre‑operative samples. The results of this study suggest that plasma miR‑200c and miR‑18a are significantly elevated in the plasma of CRC patients and that they may serve as non-invasive molecular markers for CRC screening.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang G, Zhou T, Liu Z, Tian H and Xia S: Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma. Mol Clin Oncol 1: 379-384, 2013.
APA
Zhang, G., Zhou, T., Liu, Z., Tian, H., & Xia, S. (2013). Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma. Molecular and Clinical Oncology, 1, 379-384. https://doi.org/10.3892/mco.2013.61
MLA
Zhang, G., Zhou, T., Liu, Z., Tian, H., Xia, S."Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma". Molecular and Clinical Oncology 1.2 (2013): 379-384.
Chicago
Zhang, G., Zhou, T., Liu, Z., Tian, H., Xia, S."Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma". Molecular and Clinical Oncology 1, no. 2 (2013): 379-384. https://doi.org/10.3892/mco.2013.61
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G, Zhou T, Liu Z, Tian H and Xia S: Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma. Mol Clin Oncol 1: 379-384, 2013.
APA
Zhang, G., Zhou, T., Liu, Z., Tian, H., & Xia, S. (2013). Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma. Molecular and Clinical Oncology, 1, 379-384. https://doi.org/10.3892/mco.2013.61
MLA
Zhang, G., Zhou, T., Liu, Z., Tian, H., Xia, S."Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma". Molecular and Clinical Oncology 1.2 (2013): 379-384.
Chicago
Zhang, G., Zhou, T., Liu, Z., Tian, H., Xia, S."Plasma miR‑200c and miR‑18a as potential biomarkers for the detection of colorectal carcinoma". Molecular and Clinical Oncology 1, no. 2 (2013): 379-384. https://doi.org/10.3892/mco.2013.61
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