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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases

  • Authors:
    • Hidekazu Suzuki
    • Tomonori Hirashima
    • Masashi Kobayashi
    • Norio Okamoto
    • Yuka Matsuura
    • Motohiro Tamiya
    • Naoko Morishita
    • Kohei Okafuji
    • Takayuki Shiroyama
    • Osamu Morimura
    • Satomu Morita
    • Ichiro Kawase
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka 583-8588, Japan
  • Pages: 480-482
    |
    Published online on: March 1, 2013
       https://doi.org/10.3892/mco.2013.82
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Abstract

Interstitial lung diseases (ILDs) are frequently associated with lung cancer. The safety of carboplatin plus paclitaxel in combination with bevacizumab (CP-B) in patients with ILD and lung cancer (ILD-LC) remains to be clarified. In the present study, the safety and efficacy of CP-B treatment in ILD-LC patients were retrospectively investigated. Four patients, who completed CP-B therapy, were included in this study. The dose of carboplatin was the area under the curve 5, paclitaxel was 200 mg/m2 and bevacizumab was 15 mg/kg at treatment initiation. The patients were males, had histologically confirmed adenocarcinoma, were smokers and demonstrated non-usual interstitial pneumonia (non‑UIP) patterns on computed tomography (CT). Patients received 1-6 cycles of CP-B therapy. Three of the four patients received maintenance bevacizumab therapy for 3-10 cycles. Only one patient demonstrated a partial response. Neutropenia was the most frequent adverse event. One patient experienced gut perforation during the first course of CP-B. No pulmonary toxicity was observed. Thus, treatment of ILD-LC patients with CP-B was not associated with pulmonary toxicity, however, this study population appeared to be at a low risk.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki H, Hirashima T, Kobayashi M, Okamoto N, Matsuura Y, Tamiya M, Morishita N, Okafuji K, Shiroyama T, Morimura O, Morimura O, et al: Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases. Mol Clin Oncol 1: 480-482, 2013.
APA
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M. ... Kawase, I. (2013). Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases. Molecular and Clinical Oncology, 1, 480-482. https://doi.org/10.3892/mco.2013.82
MLA
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M., Morishita, N., Okafuji, K., Shiroyama, T., Morimura, O., Morita, S., Kawase, I."Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases". Molecular and Clinical Oncology 1.3 (2013): 480-482.
Chicago
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M., Morishita, N., Okafuji, K., Shiroyama, T., Morimura, O., Morita, S., Kawase, I."Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases". Molecular and Clinical Oncology 1, no. 3 (2013): 480-482. https://doi.org/10.3892/mco.2013.82
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki H, Hirashima T, Kobayashi M, Okamoto N, Matsuura Y, Tamiya M, Morishita N, Okafuji K, Shiroyama T, Morimura O, Morimura O, et al: Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases. Mol Clin Oncol 1: 480-482, 2013.
APA
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M. ... Kawase, I. (2013). Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases. Molecular and Clinical Oncology, 1, 480-482. https://doi.org/10.3892/mco.2013.82
MLA
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M., Morishita, N., Okafuji, K., Shiroyama, T., Morimura, O., Morita, S., Kawase, I."Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases". Molecular and Clinical Oncology 1.3 (2013): 480-482.
Chicago
Suzuki, H., Hirashima, T., Kobayashi, M., Okamoto, N., Matsuura, Y., Tamiya, M., Morishita, N., Okafuji, K., Shiroyama, T., Morimura, O., Morita, S., Kawase, I."Carboplatin plus paclitaxel in combination with bevacizumab for the treatment of adenocarcinoma with interstitial lung diseases". Molecular and Clinical Oncology 1, no. 3 (2013): 480-482. https://doi.org/10.3892/mco.2013.82
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