Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Fang,Qi‑Gen; Shi,Shuang; Li,Zhen‑Ning; Zhang,Xu; Liua,Fa‑Yu; Xu,Zhong‑Fei; Sun,Chang‑Fu

doi:10.3892/mco.2013.86

May-June 2013 Volume 1 Issue 3

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May-June 2013 Volume 1 Issue 3

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Article

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

Authors:
- Qi‑Gen Fang
- Shuang Shi
- Zhen‑Ning Li
- Xu Zhang
- Fa‑Yu Liua
- Zhong‑Fei Xu
- Chang‑Fu Sun
View Affiliations / Copyright

Affiliations: Department of Oromaxillofacial‑Head and Neck Surgery, School of Stomatology, China Medical University, Heping, Shenyang, Liaoning 110002, P.R. China, Department of Pediatric Dentistry, School of Stomatology, China Medical University, Heping, Shenyang, Liaoning 110002, P.R. China, Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Heping, Shenyang, Liaoning 110002, P.R. China
Pages: 531-534
|
Published online on: March 5, 2013

https://doi.org/10.3892/mco.2013.86
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Abstract

Squamous cell carcinoma (SCC) of the buccal mucosa is a common malignancy in Southeast Asia. The purpose of this study was to present our clinical experience with buccal SCC over a period of 7 years and to analyze the factors associated with surgical outcome. We conducted a retrospective review on 67 buccal SCC patients (between September, 2005 and May, 2011) with tumors restricted to or originating from the buccal mucosa. In a univariate model, nodal stage, degree of tumor differentiation and composite resection were associated with recurrence, while in a multivariate model, the degree of differentiation was the only factor affecting locoregional control. In a survival analysis, recurrence, nodal stage and degree of differentiation were considered as significant factors. Buccal SCC is an aggressive malignant tumor and the degree of differentiation is the most significant factor affecting prognosis and survival. An adequate systemic treatment is required in the case of poorly differentiated tumors. Neck dissection (ND) exerts a positive effect on the locoregional control of buccal SCC staged as cT1‑2N0. In the case of identification of positive lymph nodes during surgery, postoperative radiation is recommended in order to improve locoregional control.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Squamous cell carcinoma of the buccal mucosa: Analysis of clinical presentation, outcome and prognostic factors

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Abstract

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