Interstitial pneumonia associated with neoadjuvant chemotherapy in breast cancer

Kawajiri,Hidemi; Takashima,Tsutomu; Onoda,Naoyoshi; Kashiwagi,Shinichiro; Ishikawa,Tetsurou; Hirakawa,Kosei

doi:10.3892/mco.2013.87

May-June 2013 Volume 1 Issue 3

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May-June 2013 Volume 1 Issue 3

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Article

Interstitial pneumonia associated with neoadjuvant chemotherapy in breast cancer

Authors:
- Hidemi Kawajiri
- Tsutomu Takashima
- Naoyoshi Onoda
- Shinichiro Kashiwagi
- Tetsurou Ishikawa
- Kosei Hirakawa
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
Pages: 433-436
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Published online on: March 5, 2013

https://doi.org/10.3892/mco.2013.87
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Abstract

Interstitial pneumonia (IP) is a critical adverse event that may occur during anticancer chemotherapy. Physicians should be aware of the possibility of IP, particularly when dealing with patients on neoadjuvant chemotherapy (NAC) since delays in diagnosis and treatment interfere with the scheduled operation. In our institution, fluorouracil, epirubicin and cyclophosphamide (FEC) followed by weekly paclitaxel is the standard NAC regimen for operable breast cancer cases. In the present study, 95 patients with breast cancer were treated with this regimen, 5 of whom (5.3%) developed IP during NAC. All 5 cases were diagnosed when anticancer therapy was withdrawn and steroid pulse therapy was initiated. Consequently, the standard operation was immediately performed. In conclusion, physicians should be aware that IP may occur at any point during NAC and that it should be immediately diagnosed and treated to avoid delay of the therapeutic plan.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Interstitial pneumonia associated with neoadjuvant chemotherapy in breast cancer

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Abstract

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