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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy

  • Authors:
    • Yuxuan Wang
    • Jianxiang Chen
    • Bo Tang
    • Xiangyu Zhang
    • Zi-Chun Hua
  • View Affiliations / Copyright

    Affiliations: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu 210093, P.R. China, Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou 213164, P.R. China
  • Pages: 461-465
    |
    Published online on: March 11, 2013
       https://doi.org/10.3892/mco.2013.90
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Abstract

Attenuated Salmonella typhimurium (S. typhi­murium) strain VNP20009 has been employed as a powerful anticancer agent due to its selective accumulation in tumors for targeted therapy. S. typhimurium has been demonstrated to constitute a delivery tool carrying antiangiogenic or proapoptotic genes that treat cancer. The hydrodynamic tail vein (HTV) injection of naked plasmid DNA has been developed as an effective gene delivery strategy, which has been successfully used in vivo. The aim of this study was to develop a combination therapy of S. typhimurium VNP20009 and HTV injection of interleukin-21 (IL-21) expression plasmid to evaluate the antitumor potential on an experimental melanoma model. Consistent with previous results, single VNP20009 treatment was demonstrated to possess effective activities to suppress tumor growth and prolong animal survival. Moreover, HTV injection of IL-21 plasmid promoted the antitumor activities of VNP20009. The mice that were administered combined therapy exhibited smaller tumor sizes and longer survival time compared with those administered VNP20009 or IL-21 treatment alone. IL-21 induced more infiltrating natural killer (NK) and T cells to the tumor area. These findings indicated that S. typhimurium in combination with IL-21 promotes antitumor immune responses, suggesting a novel strategy in the treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Chen J, Tang B, Zhang X and Hua Z: Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy. Mol Clin Oncol 1: 461-465, 2013.
APA
Wang, Y., Chen, J., Tang, B., Zhang, X., & Hua, Z. (2013). Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy. Molecular and Clinical Oncology, 1, 461-465. https://doi.org/10.3892/mco.2013.90
MLA
Wang, Y., Chen, J., Tang, B., Zhang, X., Hua, Z."Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy". Molecular and Clinical Oncology 1.3 (2013): 461-465.
Chicago
Wang, Y., Chen, J., Tang, B., Zhang, X., Hua, Z."Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy". Molecular and Clinical Oncology 1, no. 3 (2013): 461-465. https://doi.org/10.3892/mco.2013.90
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Chen J, Tang B, Zhang X and Hua Z: Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy. Mol Clin Oncol 1: 461-465, 2013.
APA
Wang, Y., Chen, J., Tang, B., Zhang, X., & Hua, Z. (2013). Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy. Molecular and Clinical Oncology, 1, 461-465. https://doi.org/10.3892/mco.2013.90
MLA
Wang, Y., Chen, J., Tang, B., Zhang, X., Hua, Z."Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy". Molecular and Clinical Oncology 1.3 (2013): 461-465.
Chicago
Wang, Y., Chen, J., Tang, B., Zhang, X., Hua, Z."Systemic administration of attenuated Salmonella typhimurium in combination with interleukin-21 for cancer therapy". Molecular and Clinical Oncology 1, no. 3 (2013): 461-465. https://doi.org/10.3892/mco.2013.90
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