Clinical efficacy of CyberKnife combined with chemotherapy and hyperthermia for advanced non‑small cell lung cancer

Wang,Yuan‑Yuan; Lin,Si‑Xiang; Yang,Gui‑Qing; Liu,Han‑Chen; Sun,Dong‑Ning; Wang,Yi‑Shan

doi:10.3892/mco.2013.95

May-June 2013 Volume 1 Issue 3

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May-June 2013 Volume 1 Issue 3

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Article

Clinical efficacy of CyberKnife combined with chemotherapy and hyperthermia for advanced non‑small cell lung cancer

Authors:
- Yuan‑Yuan Wang
- Si‑Xiang Lin
- Gui‑Qing Yang
- Han‑Chen Liu
- Dong‑Ning Sun
- Yi‑Shan Wang
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Affiliations: School of Integration of Traditional and Western Medicine, Binzhou Medical University, antai, Shandong 264002, P.R. China, Center for Tumor Treatment, the People's Liberation Army 107th Hospital, Yantai, Shandong 264002, P.R. China
Pages: 527-530
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Published online on: March 19, 2013

https://doi.org/10.3892/mco.2013.95
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Abstract

Non‑small cell lung cancer (NSCLC) is responsible for at least 80% of all lung tumors and has a poor prognosis, since 75% of NSCLCs are first diagnosed at an advanced stage. This study was conducted to evaluate the therapeutic efficacy of CyberKnife in combination with chemotherapy and hyperthermia for selected patients with advanced non‑small cell lung cancer (NSCLC). Clinical charts, imaging and pathology reports of patients with advanced NSCLC who underwent CyberKnife therapy in our Tumor Therapy Center were retrospectively reviewed. Clinical efficacy was evaluated for local control, Karnofsky performance status scale (KPS) and toxicity analysis. A total of 119 patients with 136 target areas were evaluated. A prescribed dose of 24-51 Gy to the gross tumor volume was delivered in 3-6 fractions. The median prescription dose was 35 Gy (mean, 34.73±4.80 Gy), with an average of five fractions. Patients, who voluntarily participated in the study, were assigned to one of three groups, which were as follows: CyberKnife therapy alone, CyberKnife combined with chemotherapy and CyberKnife combined with chemotherapy and hyperthermia. The median follow‑up period was 6 months and curative efficiencies were 62.16, 71.79 and 90.70%, respectively, as determined by radiographic and clinical re‑examinations. Patients treated by CyberKnife combined with chemotherapy and hyperthermia achieved optimal improvement in the aspect of KPS, which was statistically different compared to the other two groups (P<0.05). In conclusion, our results indicated that CyberKnife combined with chemotherapy and hyperthermia achieved favorable short‑term outcomes and may be a more viable option for patients with advanced NSCLC. However, further investigations are required to evaluate long‑term outcomes.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical efficacy of CyberKnife combined with chemotherapy and hyperthermia for advanced non‑small cell lung cancer

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