Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study

  • Authors:
    • Tomoharu Shimizu
    • Satoshi Murata
    • Hiromichi Sonoda
    • Eiji Mekata
    • Hiroyuki Ohta
    • Katsushi Takebayashi
    • Tohru Miyake
    • Tohru Tani
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
  • Pages: 399-404
    |
    Published online on: January 16, 2014
       https://doi.org/10.3892/mco.2014.244
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although hyperthermic intraperitoneal chemotherapy (HIPEC) has been extensively used to treat patients with peritoneal metastases (PM) from colorectal cancer (CRC), a standard protocol has not yet been established. The aim of this preliminary clinical study was to confirm in vitro the efficacy of mitomycin C combined with 5‑fluorouracil (MMC‑5FU) under hyperthermic conditions in CRC and investigate the pharmacokinetics and feasibility of HIPEC with MMC‑5FU for patients at high risk of PM from CRC. To simulate HIPEC in vitro, we used the collagen gel droplet‑embedded culture drug sensitivity test with the HCT166 colorectal cell line to assess the antitumor efficacy of MMC and 5FU as single‑agent and combination treatments following incubation with HCT116 cells for 30 min at either 37 or 42˚C. In addition, five patients at high risk of PM from CRC underwent surgical tumor resection followed by HIPEC with MMC‑5FU. Our results demonstrated that the combined administration of MMC‑5FU suppressed tumor cell proliferation more efficiently compared to either agent used alone. In addition, hyperthermia at 42˚C significantly enhanced drug sensitivity. During the clinical application of HIPEC with MMC‑5FU, no grade 4 hematological toxicities or surgical adverse events were recorded. In addition, there was no evidence of peritoneal recurrence during a median observational period of 38 months. Of note, two patients with positive intraoperative peritoneal cytology at the first surgery developed no peritoneal recurrence and exhibited negative peritoneal cytology at the second surgery. In conclusion, HIPEC using MMC‑5FU was shown to be a feasible therapeutic option, with an acceptable toxicity profile, for patients at high risk of PM from CRC. Therefore, HIPEC with MMC‑5FU may be a promising novel therapeutic option for such patients, which merits further verification of its safety and efficacy in large‑scale clinical trials.
View Figures

Figure 1

Figure 2

Figure 3

View References

1. 

Stewart JH IV, Shen P and Levine EA: Intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: current status and future directions. Ann Surg Oncol. 12:765–777. 2005. View Article : Google Scholar

2. 

Chua TC, Esquivel J, Pelz JO and Morris DL: Summary of current therapeutic options for peritoneal metastases from colorectal cancer. J Surg Oncol. 107:566–573. 2013. View Article : Google Scholar : PubMed/NCBI

3. 

Mohr Z, Hirche C, Liebeskind U, Rau B and Hunerbein M: Feasibility of delayed hyperthermic intraperitoneal chemotherapy in case of unforeseen complications. Eur Surg Res. 47:19–25. 2011. View Article : Google Scholar : PubMed/NCBI

4. 

Yonemura Y, Elnemr A, Endou Y, et al: Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer. World J Gastrointest Oncol. 2:85–97. 2010. View Article : Google Scholar : PubMed/NCBI

5. 

Imano M, Imamoto H, Itoh T, et al: Impact of intraperitoneal chemotherapy after gastrectomy with positive cytological findings in peritoneal washings. Eur Surg Res. 47:254–259. 2011. View Article : Google Scholar : PubMed/NCBI

6. 

Fujishima Y, Goi T, Kimura Y, Hirono Y, Katayama K and Yamaguchi A: MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer. Int J Oncol. 40:960–964. 2012.

7. 

Bosanquet DC, Harris DA, Evans MD and Beynon J: Systematic review and meta-analysis of intraoperative peritoneal lavage for colorectal cancer staging. Br J Surg. 100:853–862. 2013. View Article : Google Scholar

8. 

Mohan HM, O’Connor DB, O’Riordan JM and Winter DC: Prognostic significance of detection of microscopic peritoneal disease in colorectal cancer: a systematic review. Surg Oncol. 22:e1–e6. 2013. View Article : Google Scholar : PubMed/NCBI

9. 

Glockzin G, Rochon J, Arnold D, et al: A prospective multicenter phase II study evaluating multimodality treatment of patients with peritoneal carcinomatosis arising from appendiceal and colorectal cancer: the COMBATAC trial. BMC Cancer. 13:672013. View Article : Google Scholar

10. 

Koppe MJ, Boerman OC, Oyen WJ and Bleichrodt RP: Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg. 243:212–222. 2006. View Article : Google Scholar : PubMed/NCBI

11. 

Klaver YL, Hendriks T, Lomme RM, Rutten HJ, Bleichrodt RP and de Hingh IH: Intraoperative versus early postoperative intraperitoneal chemotherapy after cytoreduction for colorectal peritoneal carcinomatosis: an experimental study. Ann Surg Oncol. 19(Suppl 3): S475–S482. 2012. View Article : Google Scholar

12. 

Weber T, Roitman M and Link KH: Current status of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from colorectal cancer. Clin Colorectal Cancer. 11:167–176. 2012. View Article : Google Scholar

13. 

Kobayashi H, Tanisaka K, Doi O, et al: An in vitro chemosensitivity test for solid human tumors using collagen gel droplet embedded cultures. Int J Oncol. 11:449–455. 1997.

14. 

Okumura K, Shiomi H, Mekata E, et al: Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer. Oncol Rep. 15:875–882. 2006.

15. 

Muller M, Cherel M, Dupre PF, Gouard S, Collet M and Classe JM: The cytotoxic effect of combined hyperthermia and taxane chemotherapy on ovarian cancer cells: results of an in vitro study. Eur Surg Res. 48:55–63. 2012. View Article : Google Scholar : PubMed/NCBI

16. 

Sugarbaker PH: Intraperitoneal chemotherapy and cytoreductive surgery for the prevention and treatment of peritoneal carcinomatosis and sarcomatosis. Semin Surg Oncol. 14:254–261. 1998. View Article : Google Scholar : PubMed/NCBI

17. 

Kuzuya T, Yamauchi M, Ito A, Hasegawa M, Hasegawa T and Nabeshima T: Pharmacokinetic characteristics of 5-fluorouracil and mitomycin C in intraperitoneal chemotherapy. J Pharm Pharmacol. 46:685–689. 1994. View Article : Google Scholar : PubMed/NCBI

18. 

Pestieau SR, Marchettini P, Stuart OA, Chang D and Sugarbaker PH: Prevention of intraperitoneal adhesions by intraperitoneal lavage and intraperitoneal 5-fluorouracil: experimental studies. Int Surg. 87:195–200. 2002.PubMed/NCBI

19. 

Sugarbaker PH and Jablonski KA: Prognostic features of 51 colorectal and 130 appendiceal cancer patients with peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemotherapy. Ann Surg. 221:124–132. 1995. View Article : Google Scholar

20. 

Sugarbaker PH: Cytoreductive surgery plus hyperthermic perioperative chemotherapy for selected patients with peritoneal metastases from colorectal cancer: a new standard of care or an experimental approach? Gastroenterol Res Pract. 2012:3094172012. View Article : Google Scholar

21. 

Wyatt MD and Wilson DM III: Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci. 66:788–799. 2009. View Article : Google Scholar : PubMed/NCBI

22. 

De Roover A, Detroz B, Detry O, et al: Adjuvant hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) associated with curative surgery for locally advanced gastric carcinoma. An initial experience. Acta Chir Belg. 106:297–301. 2006.

23. 

Tentes AA, Spiliotis ID, Korakianitis OS, Vaxevanidou A and Kyziridis D: Adjuvant perioperative intraperitoneal chemotherapy in locally advanced colorectal carcinoma: preliminary results. ISRN Surg. 2011:5298762011. View Article : Google Scholar

24. 

Raue W, Tsilimparis N, Bloch A, Menenakos C and Hartmann J: Volume therapy and cardiocircular function during hyperthermic intraperitoneal chemotherapy. Eur Surg Res. 43:365–372. 2009. View Article : Google Scholar : PubMed/NCBI

25. 

Mizumoto A, Canbay E, Hirano M, et al: Morbidity and mortality outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a single institution in Japan. Gastroenterol Res Pract. 2012:8364252012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shimizu T, Murata S, Sonoda H, Mekata E, Ohta H, Takebayashi K, Miyake T and Tani T: Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study. Mol Clin Oncol 2: 399-404, 2014.
APA
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K. ... Tani, T. (2014). Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study. Molecular and Clinical Oncology, 2, 399-404. https://doi.org/10.3892/mco.2014.244
MLA
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K., Miyake, T., Tani, T."Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study". Molecular and Clinical Oncology 2.3 (2014): 399-404.
Chicago
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K., Miyake, T., Tani, T."Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study". Molecular and Clinical Oncology 2, no. 3 (2014): 399-404. https://doi.org/10.3892/mco.2014.244
Copy and paste a formatted citation
x
Spandidos Publications style
Shimizu T, Murata S, Sonoda H, Mekata E, Ohta H, Takebayashi K, Miyake T and Tani T: Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study. Mol Clin Oncol 2: 399-404, 2014.
APA
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K. ... Tani, T. (2014). Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study. Molecular and Clinical Oncology, 2, 399-404. https://doi.org/10.3892/mco.2014.244
MLA
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K., Miyake, T., Tani, T."Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study". Molecular and Clinical Oncology 2.3 (2014): 399-404.
Chicago
Shimizu, T., Murata, S., Sonoda, H., Mekata, E., Ohta, H., Takebayashi, K., Miyake, T., Tani, T."Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5‑fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study". Molecular and Clinical Oncology 2, no. 3 (2014): 399-404. https://doi.org/10.3892/mco.2014.244
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team