Contribution of diuretic therapy with human serum albumin to the management of ascites in patients with advanced liver cirrhosis: A prospective cohort study

Nakamura,Toru; Sata,Michio; Hiroishi,Kazumasa; Masaki,Naohiko; Moriwaki,Hisataka; Murawaki,Yoshikazu; Yatsuhashi,Hiroshi; Fujiyama,Shigetoshi; Imawari,Michio

doi:10.3892/mco.2014.245

May-June 2014 Volume 2 Issue 3

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May-June 2014 Volume 2 Issue 3

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Article

Contribution of diuretic therapy with human serum albumin to the management of ascites in patients with advanced liver cirrhosis: A prospective cohort study

Authors:
- Toru Nakamura
- Michio Sata
- Kazumasa Hiroishi
- Naohiko Masaki
- Hisataka Moriwaki
- Yoshikazu Murawaki
- Hiroshi Yatsuhashi
- Shigetoshi Fujiyama
- Michio Imawari
View Affiliations / Copyright

Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830‑0011, Japan, Division of Gastroenterology and Hepatology, Department of Medicine, Showa University School of Medicine, Shinagawa‑ku, Tokyo 142‑8666, Japan, Department of Gastroenterology, National Center for Global Health and Medicine, Shinjuku‑ku, Tokyo 162‑8655, Japan, Department of Gastroenterology, Gifu University School of Medicine, Gifu 501‑1194, Japan, Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8504, Japan, Clinical Research Center, National Hospital Organization, Nagasaki Medical Center, Omura, Nagasaki 856‑8562, Japan, Department of Gastroenterology and Hepatology, NTT West Kyushu Hospital, Chuo‑ku, Kumamoto 862‑8655, Japan
Pages: 349-355
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Published online on: January 16, 2014

https://doi.org/10.3892/mco.2014.245
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Abstract

The number of available studies on the role of human serum albumin (HSA) in the treatment of cirrhotic ascites is currently limited. In this study, we aimed to investigated the parameters associated with diuretic therapy with HSA in patients with advanced cirrhotic ascites. The patient inclusion criteria were cirrhotic ascites and a serum albumin (Alb) concentration of <3.5 g̸dl. A total of 49 patients registered and 38 patients were ultimately included in this study. The enrolled patients were mainly treated with oral spironolactone and furosemide, which were not specified; the HSA amount was also not specified, although the administration period was set to a maximum of 7 days. Our results demonstrated that the administration of HSA significantly increased the serum levels of Alb [0.97 g̸dl; two‑sided 95% confidence interval (CI): 0.83‑1.11 g̸dl] and decreased body weight (‑2.24 kg; 95% CI: ‑3.06 to ‑1.43 kg), hematocrit ratio (0.96; 95% CI: 0.94‑0.98) and plasma renin concentration (day 4; geometric mean fold change, ‑0.1528; 95% CI: ‑0.2510 to ‑0.0545; log‑transformed data) in patients with advanced cirrhotic ascites. The observed weight loss was found to be correlated with the total amount of HSA administered (P=0.0012), as indicated by the results of the multiple linear regression analysis. In conclusion, this study confirmed the efficacy of HSA in patients with advanced cirrhotic ascites.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Contribution of diuretic therapy with human serum albumin to the management of ascites in patients with advanced liver cirrhosis: A prospective cohort study

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