Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells

  • Authors:
    • Ya‑Jen Chang
    • Wei‑Hsin Hsu
    • Chih‑Hsien Chang
    • Keng‑Li Lan
    • Gann Ting
    • Te‑Wei Lee
  • View Affiliations / Copyright

    Affiliations: Institute of Nuclear Energy Research, Lungtan, Taoyuan, Taiwan, R.O.C., Cancer Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C., National Health Research Institutes, Taipei, Taiwan, R.O.C.
  • Pages: 380-384
    |
    Published online on: January 20, 2014
       https://doi.org/10.3892/mco.2014.246
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rhenium‑188 (188Re) displays abundant intermediate energy β emission and possesses a physical half‑life of 16.9 h. Sorafenib is an orally available multikinase inhibitor that targets Raf kinases and vascular endothelial growth factor receptors (VEGFRs). Sorafenib has demonstrated preclinical and clinical activity against several types of tumors, such as renal cell and colorectal carcinoma. In this study, we investigated the efficacy of radiotherapeutics of 188Re‑liposomes combined with sorafenib in a C26‑luc metastatic colorectal liver tumour mouse model. Liver metastases were established by intrasplenic injection of C26‑luc murine colon cancer cells. Based on the results of the toxicity assessment, an administration dose of 80% the maximum tolerated dose was selected. 188Re‑liposomes were administered on day 1, when metastases of several hundred micrometers in diameter were observed. In the combination therapy group, 10 mg̸kg sorafenib (co‑developed and co‑marketed by Bayer and Onyx Pharmaceuticals as Nexavar) was administered every other day for 1 week and the survival of mice was assessed. The tumor growth was more significantly inhibited in the 188Re‑liposome plus sorafenib group compared with the 188Re‑liposome alone, sorafenib alone and untreated normal saline groups (P=0.0000). Furthermore, 188Re‑liposomes combined with sorafenib achieved higher survival rates compared with the 188Re‑liposome alone, sorafenib alone and untreated normal saline groups (P=0.0000). These results support the use of combined radio‑chemotherapy with 188Re‑liposomes plus sorafenib as a viable treatment option in the adjuvant setting for liver metastases of colorectal cancer.
View Figures

Figure 1

Figure 2

View References

1. 

Reissfelder C, Timke C, Schmitz-Winnenthal H, et al: A randomized controlled trial to investigate the influence of low dose radiotherapy on immune stimulatory effects in liver metastases of colorectal cancer. BMC Cancer. 11:4192011. View Article : Google Scholar

2. 

Reissfelder C, Rahbari NN, Koch M, Ulrich A, Pfeilschifter I, Waltert A, Muller SA, Schemmer P, Buchler MW and Weitz J: Validation of prognostic scoring systems for patients undergoing resection of colorectal cancer liver metastases. Ann Surg Oncol. 16:3279–3288. 2009. View Article : Google Scholar : PubMed/NCBI

3. 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

4. 

Cummings LC, Payes JD and Cooper GS: Survival after hepatic resection in metastatic colorectal cancer: a population-based study. Cancer. 109:718–726. 2007. View Article : Google Scholar : PubMed/NCBI

5. 

Vavrova J and Rezacova M: The importance of senescence in ionizing radiation-induced tumour suppression. Folia Biol. 57:41–46. 2011.PubMed/NCBI

6. 

Bakkenist CJ and Kastan MB: DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499–506. 2003. View Article : Google Scholar : PubMed/NCBI

7. 

Jeggo PA, Geuting V and Lobrich M: The role of homologous recombination in radiation-induced double-strand break repair. Radiother Oncol. 101:7–12. 2011. View Article : Google Scholar : PubMed/NCBI

8. 

Lobrich M and Jeggo PA: The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer. 7:861–869. 2007. View Article : Google Scholar : PubMed/NCBI

9. 

Jeggo PA and Löbrich M: DNA double-strand breaks: their cellular and clinical impact? Oncogene. 26:7717–7719. 2007. View Article : Google Scholar : PubMed/NCBI

10. 

Davis ME, Chen ZG and Shin DM: Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 7:771–782. 2008. View Article : Google Scholar : PubMed/NCBI

11. 

Cho K, Wang X, Nie S, Chen ZG and Shin DM: Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res. 14:1310–1316. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Wolpin BM, Meyerhardt JA, Mamon HJ and Mayer RJ: Adjuvant treatment of colorectal cancer. CA Cancer J Clin. 57:168–185. 2007. View Article : Google Scholar

13. 

Brannon-Peppas L and Blanchette JO: Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev. 56:1649–1659. 2004. View Article : Google Scholar : PubMed/NCBI

14. 

Chang YJ, Chang CH, Chang TJ, Yu CY, Chen LC, Jan ML, Luo TY, Lee TW and Ting G: Biodistribution, pharmacokinetics and microSPECT/CT imaging of 188Re-bMEDA-liposome in a C26 murine colon carcinoma solid tumor animal model. Anticancer Res. 27:2217–2225. 2007.PubMed/NCBI

15. 

Chen LC, Chang CH, Yu CY, Chang YJ, Hsu WC, Ho CL, Yeh CH, Luo TY, Lee TW and Ting G: Biodistribution, pharmacokinetics and imaging of 188Re-BMEDA-labeled pegylated liposomes after intraperitoneal injection in a C26 colon carcinoma ascites mouse model. Nucl Med Biol. 34:415–423. 2007.

16. 

Ibrahim N, Yu Y, Walsh WR and Yang JL: Molecular targeted therapies for cancer: Sorafenib mono-therapy and its combination with other therapies (Review). Oncol Rep. 27:1303–1311. 2012.PubMed/NCBI

17. 

Dal Lago L, D′Hondt V and Awada A: Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors. Oncologist. 13:845–858. 2008.PubMed/NCBI

18. 

Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 7:3129–3140. 2008. View Article : Google Scholar : PubMed/NCBI

19. 

Wilhelm SM, Carter C, Tang L, et al: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64:7099–7109. 2004. View Article : Google Scholar : PubMed/NCBI

20. 

Escudier B, Eisen T, Stadler WM, et al TARGET Study Group: Sorafenib in advanced clear-cell renal-cell carcinoma. New Engl J Med. 356:125–134. 2007. View Article : Google Scholar : PubMed/NCBI

21. 

Llovet JM, Ricci S, Mazzaferro V, et al SHARP Investigators Study Group: Sorafenib in advanced hepatocellular carcinoma. New Engl J Med. 359:378–390. 2008. View Article : Google Scholar : PubMed/NCBI

22. 

Suen AW, Galoforo S, Marples B, McGonagle M, Downing L, Martinez AA, Robertson JM and Wilson GD: Sorafenib and radiation: a promising combination in colorectal cancer. Int J Radiat Oncol Biol Phys. 78:213–220. 2010. View Article : Google Scholar : PubMed/NCBI

23. 

Kim YB, Jeung HC, Jeong I, Lee K, Rha SY, Chung HC and Kim GE: Mechanism of enhancement of radiation-induced cytotoxicity by sorafenib in colorectal cancer. J Radiat Res. 54:52–60. 2013. View Article : Google Scholar : PubMed/NCBI

24. 

Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S and Bardelli A: Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 26:5705–5712. 2008.

25. 

Ratain MJ, Eisen T, Stadler WM, et al: Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol. 24:2505–2512. 2006. View Article : Google Scholar

26. 

Wehler TC, Hamdi S, Maderer A, et al: Single-agent therapy with sorafenib or 5-FU is equally effective in human colorectal cancer xenograft - no benefit of combination therapy. Int J Colorect Dis. 28:385–398. 2013. View Article : Google Scholar : PubMed/NCBI

27. 

Kuo YC, Lin WC, Chiang IT, Chang YF, Chen CW, Su SH, Chen CL and Hwang JJ: Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-kappaB expression in vitro and in vivo. Biomed Pharmacother. 66:12–20. 2012. View Article : Google Scholar : PubMed/NCBI

28. 

Martinelli E, Troiani T, Morgillo F, et al: Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells. Clin Cancer Res. 16:4990–5001. 2010. View Article : Google Scholar : PubMed/NCBI

29. 

Galal KM, Khaled Z and Mourad AM: Role of cetuximab and sorafenib in treatment of metastatic colorectal cancer. Indian J Cancer. 48:47–54. 2011. View Article : Google Scholar : PubMed/NCBI

30. 

Plastaras JP, Kim SH, Liu YY, et al: Cell cycle dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res. 67:9443–9454. 2007. View Article : Google Scholar : PubMed/NCBI

31. 

Amundson SA, Bittner M and Fornace AJ Jr: Functional genomics as a window on radiation stress signaling. Oncogene. 22:5828–5833. 2003. View Article : Google Scholar : PubMed/NCBI

32. 

Abraham RT: Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays. 25:627–630. 2003. View Article : Google Scholar : PubMed/NCBI

33. 

Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S and Dent P: Radiation-induced cell signaling: inside-out and outside-in. Mol Cancer Ther. 6:789–801. 2007. View Article : Google Scholar : PubMed/NCBI

34. 

Dent P, Yacoub A, Fisher PB, Hagan MP and Grant S: MAPK pathways in radiation responses. Oncogene. 22:5885–5896. 2003. View Article : Google Scholar : PubMed/NCBI

35. 

Deshpande A, Sicinski P and Hinds PW: Cyclins and cdks in development and cancer: a perspective. Oncogene. 24:2909–2915. 2005. View Article : Google Scholar : PubMed/NCBI

36. 

Jirawatnotai S, Hu Y, Michowski W, et al: A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 474:230–234. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chang YJ, Hsu WH, Chang CH, Lan KL, Ting G and Lee TW: Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells. Mol Clin Oncol 2: 380-384, 2014.
APA
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., & Lee, T. (2014). Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells. Molecular and Clinical Oncology, 2, 380-384. https://doi.org/10.3892/mco.2014.246
MLA
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., Lee, T."Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells". Molecular and Clinical Oncology 2.3 (2014): 380-384.
Chicago
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., Lee, T."Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells". Molecular and Clinical Oncology 2, no. 3 (2014): 380-384. https://doi.org/10.3892/mco.2014.246
Copy and paste a formatted citation
x
Spandidos Publications style
Chang YJ, Hsu WH, Chang CH, Lan KL, Ting G and Lee TW: Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells. Mol Clin Oncol 2: 380-384, 2014.
APA
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., & Lee, T. (2014). Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells. Molecular and Clinical Oncology, 2, 380-384. https://doi.org/10.3892/mco.2014.246
MLA
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., Lee, T."Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells". Molecular and Clinical Oncology 2.3 (2014): 380-384.
Chicago
Chang, Y., Hsu, W., Chang, C., Lan, K., Ting, G., Lee, T."Combined therapeutic efficacy of 188Re‑liposomes and sorafenib in an experimental colorectal cancer liver metastasis model by intrasplenic injection of C26‑luc murine colon cancer cells". Molecular and Clinical Oncology 2, no. 3 (2014): 380-384. https://doi.org/10.3892/mco.2014.246
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team