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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis

  • Authors:
    • Meng Yang
    • Xiaocong Kuang
    • Yanbin Pan
    • Meile Tan
    • Binzhu Lu
    • Jian Lu
    • Qiumei Cheng
    • Jianmin Li
  • View Affiliations / Copyright

    Affiliations: Postgraduate School, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Pathophysiology, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Dermatology, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China
  • Pages: 363-368
    |
    Published online on: January 22, 2014
       https://doi.org/10.3892/mco.2014.247
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Abstract

Angiogenesis is a potential prognostic factor that has been extensively investigated in patients with uveal melanoma (UM). Vascular endothelial growth factor (VEGF) expression is crucial in angiogenesis. However, there have been conflicting data regarding the clinicopathological data in UM. A meta‑analysis was performed of all the germane literature to assess the clinicopathological characteristics of VEGF expression by combining separately estimated odds ratio (OR) values. Our combined results demonstrated that, according to the available studies, the expression of VEGF in UM was significantly higher compared to normal tissue [338 patients and 99 controls; OR=16.15, 95% confidence interval (CI): 8.65‑30.12, P<0.00001]. When stratifying the studies by age (315 patients; OR=2.08, 95% CI: 1.19‑3.62, P=0.01), cell type (423 patients; OR=0.54, 95% CI: 0.32‑0.90, P=0.02), tumor size (222 patients; OR=0.30, 95% CI: 0.14‑0.68, P=0.004) and scleral invasion (248 patients; OR=0.34, 95% CI: 0.15‑0.78, P=0.01), significant clinicopathological information was provided. Our results indicated that VEGF expression in UM patients was significantly higher compared to that observed in controls. It was also significantly higher in patients who presented with scleral invasion and those who were aged <50 years. In addition, VEGF expression was higher in mixed‑cell type and epithelioid‑cell type UM and in patients with large‑sized tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Yang M, Kuang X, Pan Y, Tan M, Lu B, Lu J, Cheng Q and Li J: Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis. Mol Clin Oncol 2: 363-368, 2014.
APA
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J. ... Li, J. (2014). Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis. Molecular and Clinical Oncology, 2, 363-368. https://doi.org/10.3892/mco.2014.247
MLA
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J., Cheng, Q., Li, J."Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis". Molecular and Clinical Oncology 2.3 (2014): 363-368.
Chicago
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J., Cheng, Q., Li, J."Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis". Molecular and Clinical Oncology 2, no. 3 (2014): 363-368. https://doi.org/10.3892/mco.2014.247
Copy and paste a formatted citation
x
Spandidos Publications style
Yang M, Kuang X, Pan Y, Tan M, Lu B, Lu J, Cheng Q and Li J: Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis. Mol Clin Oncol 2: 363-368, 2014.
APA
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J. ... Li, J. (2014). Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis. Molecular and Clinical Oncology, 2, 363-368. https://doi.org/10.3892/mco.2014.247
MLA
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J., Cheng, Q., Li, J."Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis". Molecular and Clinical Oncology 2.3 (2014): 363-368.
Chicago
Yang, M., Kuang, X., Pan, Y., Tan, M., Lu, B., Lu, J., Cheng, Q., Li, J."Clinicopathological characteristics of vascular endothelial growth factor expression in uveal melanoma: A meta‑analysis". Molecular and Clinical Oncology 2, no. 3 (2014): 363-368. https://doi.org/10.3892/mco.2014.247
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