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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis

  • Authors:
    • Yanfeng Liu
    • Pengcheng He
    • Feng Liu
    • Lili Shi
    • Huachao Zhu
    • Xiaoyan Cheng
    • Jing Zhao
    • Yuan Wang
    • Mei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 411-414
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/mco.2014.248
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Abstract

A number of studies have provided estimates of the correlation between B‑cell lymphoma 2 (Bcl‑2) expression and its clinical significance in acute leukemia (AL); however, the results have been heterogeneous. In order to clarify the prognostic significance of Bcl‑2 status in patients with AL, a systematic review and meta‑analysis of 5 published studies including a total of 665 subjects was performed. The reported frequency of Bcl‑2 expression was 0‑99.00%. Bcl‑2‑positive patients had a higher median white blood cell count compared to Bcl‑2‑negative patients. Additionally, Bcl‑2‑negative patients had >2‑fold higher odds of achieving complete remission (CR) compared to Bcl‑2‑positive patients. The summary hazard ratio of Bcl‑2 negativity̸positivity for CR was 0.62 [95% confidence interval: 0.53‑0.81, P<0.001]. Although this meta‑analysis was based on data abstracted from observational studies, our results may justify the use of risk‑adapted therapeutic strategies for AL according to the Bcl‑2 expression status.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, He P, Liu F, Shi L, Zhu H, Cheng X, Zhao J, Wang Y and Zhang M: Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis. Mol Clin Oncol 2: 411-414, 2014.
APA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X. ... Zhang, M. (2014). Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 2, 411-414. https://doi.org/10.3892/mco.2014.248
MLA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X., Zhao, J., Wang, Y., Zhang, M."Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis". Molecular and Clinical Oncology 2.3 (2014): 411-414.
Chicago
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X., Zhao, J., Wang, Y., Zhang, M."Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis". Molecular and Clinical Oncology 2, no. 3 (2014): 411-414. https://doi.org/10.3892/mco.2014.248
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, He P, Liu F, Shi L, Zhu H, Cheng X, Zhao J, Wang Y and Zhang M: Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis. Mol Clin Oncol 2: 411-414, 2014.
APA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X. ... Zhang, M. (2014). Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 2, 411-414. https://doi.org/10.3892/mco.2014.248
MLA
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X., Zhao, J., Wang, Y., Zhang, M."Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis". Molecular and Clinical Oncology 2.3 (2014): 411-414.
Chicago
Liu, Y., He, P., Liu, F., Shi, L., Zhu, H., Cheng, X., Zhao, J., Wang, Y., Zhang, M."Prognostic significance of B‑cell lymphoma 2 expression in acute leukemia: A systematic review and meta‑analysis". Molecular and Clinical Oncology 2, no. 3 (2014): 411-414. https://doi.org/10.3892/mco.2014.248
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