Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2014 Volume 2 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer

  • Authors:
    • Michio Kimura
    • Eiseki Usami
    • Tetsufumi Kanematsu
    • Mina Iwai
    • Tomoaki Yoshimura
    • Hiromi Mori
    • Tadashi Sugiyama
    • Hitomi Teramachi
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Ogaki Municipal Hospital, Ogaki, Gifu 503‑8502, Japan, Department of Pharmacy, Gifu Social Insurance Hospital, Kani, Gifu 509-0206, Japan, Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, Gifu 501‑1196, Japan, Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Gifu 501‑1196, Japan
  • Pages: 466-472
    |
    Published online on: February 14, 2014
       https://doi.org/10.3892/mco.2014.260
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the treatment of advanced or recurrent gastric cancer, the prolongation of survival depends on the use of second‑line therapy, with paclitaxel (PTX) or irinotecan (CPT‑11) as the key agents. The present study aimed to retrospectively investigate the safety and continuity of weekly PTX and CPT‑11 monotherapy as second‑ or third‑line treatment for advanced or recurrent gastric cancer. A total of 62 patients who had received PTX or CPT‑11 for gastric cancer at the Ogaki Municipal Hospital (Ogaki, Japan) were retrospectively reviewed. Of the 47 patients who received PTX as second‑line therapy, 13 (27.7%) received third‑line therapy with CPT‑11. Second‑line PTX and third‑line CPT‑11 were discontinued due to progressive disease (PD) in 27 and 7 cases, respectively, and deterioration in the performance status (PS) in 20 and 4 cases, respectively. Only 1 case of discontinuation due to adverse events (AEs) was reported for third‑line CPT‑11. Furthermore, of the 15 patients who received CPT‑11 as second‑line treatment, 11 (73.3%) then received PTX as third‑line treatment. Second‑line CPT‑11 and third‑line PTX were discontinued due to PD in 9 and 6 cases, respectively, and deterioration in the PS in 4 and 5 cases, respectively, whereas there was only 1 case of discontinuation due to AEs for second‑line CPT‑11. Severe AEs for PTX and CPT‑11 were infrequent; however, the frequency of diarrhea was high when PTX was administered as third‑line therapy (63.6%), whereas the frequency of malaise was high when CPT‑11 was administered as second‑ (73.3%) and third‑line (76.9%) therapy. In conclusion, severe AEs due to PTX and CPT‑11 as second‑ and third‑line treatment for advanced or recurrent gastric cancer are infrequent and patients are generally able to continue treatment. However, the possibility of diarrhea with third‑line PTX and malaise with second‑ and third‑line CPT‑11 treatment should be considered when planning chemotherapy.
View Figures
View References

1. 

Boku N, Yamamoto S, Fukuda H, et al Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group: Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study. Lancet Oncol. 10:1063–1069. 2009. View Article : Google Scholar : PubMed/NCBI

2. 

Koizumi W, Narahara H, Hara T, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 9:215–221. 2008. View Article : Google Scholar : PubMed/NCBI

3. 

Shitara K, Oze I, Mizota A, et al: Randomized phase II study comparing dose escalated weekly paclitaxel vs. standard dose weekly paclitaxel for patients with previously treated advanced gastric cancer. Jpn J Clin Oncol. 41:287–290. 2011. View Article : Google Scholar

4. 

Shimoyama R, Yasui H, Boku N, et al: Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin. Gastric Cancer. 12:206–211. 2009. View Article : Google Scholar : PubMed/NCBI

5. 

Hironaka S, Zenda S, Boku N, Fukutomi A, Yoshino T and Onozawa Y: Weekly paclitaxel as second-line chemotherapy for advanced or recurrent gastric cancer. Gastric Cancer. 9:14–18. 2006. View Article : Google Scholar : PubMed/NCBI

6. 

Egawa T, Kubota T, Nagashima A, Doi M, Kitano M, Hayashi S, Yoshii H, Saikawa Y and Kitajima M: Usefulness of weekly administration of paclitaxel for advanced or recurrent gastric cancer. Jpn J Canc Chemother. 31:877–881. 2004.(In Japanese).

7. 

Koizumi W, Akiya T, Sato A, Yamaguchi K, Sakuyama T, Nakayama N, Tanabe S, Higuchi K, Sasaki T and Sekikawa T; Tokyo Cooperative Oncology Group (TCOG GI Group): Second-line chemotherapy with biweekly paclitaxel after failure of fluoropyrimidine-based treatment in patients with advanced or recurrent gastric cancer: a report from the gastrointestinal oncology group of the Tokyo Cooperative Oncology Group, TCOG GC-0501 trial. Jpn J Clin Oncol. 39:713–719. 2009.

8. 

Matsuda G, Kunisaki C, Makino H, et al: Phase II study of weekly paclitaxel as a second-line treatment for S-1-refractory advanced gastric cancer. Anticancer Res. 29:2863–2867. 2009.PubMed/NCBI

9. 

Kodera Y, Ito S, Mchizuki Y, et al Chubu Clinical Cancer Group: A phase II study of weekly paclitaxel as second-line chemotherapy for advanced gastric cancer (CCOG0302 study). Anticancer Res. 27:2667–2671. 2007.PubMed/NCBI

10. 

Chun JH, Kim HK, Lee JS, Choi JY, Lee HG, Yoon SM, Choi IJ, Ryu KW, Kim YW and Bae JM: Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy. Jpn J Clin Oncol. 34:8–13. 2004. View Article : Google Scholar : PubMed/NCBI

11. 

Kawamura H, Yokota R, Watarai H, et al: Third-line CPT-11 chemotheraphy for gastric cancer cases of non-curative gastrectomy or recurrence. Jpn J Canc Chemother. 37:1051–1054. 2010.(In Japanese).

12. 

Kuculzeybek Y, Dirican A, Erten C, Somali I, Can A, Demir L, Bayoglu IV, Akyol M, Medeni M and Tarhan MO: Second-line irinotecan after cisplatin, fluoropyrimidin and docetaxel for chemotherapy of metastatic gastric cancer. Asian Pac J Cancer Prev. 13:2771–2774. 2012. View Article : Google Scholar : PubMed/NCBI

13. 

Oda H, Mizuno T, Yamashita Y, Nomura H, Saito K, Tamaru S, Kageyama S and Katayama N: Irinotecan as second-line chemotherapy for 5-FU-resistant gastric cancer with disseminated intravascular coagulation: a case report. Jpn J Canc Chemother. 38:1517–1520. 2011.(In Japanese).

14. 

Goto A, Sukawa Y, Igarashi H, et al: Irinotecan as the key chemotherapeutic agent in second-line treatment of metastatic gastric cancer after failure of first-line S-1 or S-1/CDDP therapy. Jpn J Canc Chemother. 38:1461–1466. 2011.(In Japanese).

15. 

Farhat FS: A general review of the role of irinotecan (CPT11) in the treatment of gastric cancer. Med Oncol. 24:137–146. 2007. View Article : Google Scholar : PubMed/NCBI

16. 

Fujitani K, Narahara H, Takiuchi H, Tsujinaka T, Satomi E, Gotoh M, Hirao M, Furukawa H and Taguchi T: Phase I and pharmacokinetic study of S-1 combined with weekly paclitaxel in patients with advanced gastric cancer. Oncology. 69:414–420. 2005. View Article : Google Scholar : PubMed/NCBI

17. 

Kumagai K, Saikawa Y, Nakamura R, Takahashi T, Kubota T, Kumai K, Kitagawa Y and Kitajima M: Clinical experience of second-line chemotherapy with S-1/CPT-11 for highly advanced gastric cancer. Jpn J Canc Chemother. 35:245–250. 2008.(In Japanese).

18. 

Komatsu Y, Yuki S, Fuse N, et al: Phase 1/2 clinical study of irinotecan and oral S-1 (IRIS) in patients with advanced gastric cancer. Adv Ther. 27:483–492. 2010. View Article : Google Scholar : PubMed/NCBI

19. 

Shitara K, Matsuo K, Mizota A, et al: Association of fluoropyrimidines, platinum agents, taxanes, and irinotecan in any line of chemotherapy with survival in patients with advanced gastric cancer. Gastric Cancer. 14:155–160. 2011. View Article : Google Scholar : PubMed/NCBI

20. 

Thuss-Patience PC, Kretzschmar A, Bichev D, Deist T, Hinke A, Breithaupt K, Dogan Y, Gebauer B, Schumacher G and Reichardt P: Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer - a randomized phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Eur J Cancer. 47:2306–2314. 2011. View Article : Google Scholar

21. 

Kang JH, Lee SI, Lim do H, et al: Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol. 30:1513–1518. 2012. View Article : Google Scholar : PubMed/NCBI

22. 

Akasaka O, Iwase S, Miwa H, Ando T, Morita S, Koh R, Kasama M, Matsueda R and Anan H: Combination chemotherapy of S-1 and CPT-11 for advanced recurrent gastric cancer. Jpn J Canc Chemother. 36:1833–1837. 2009.(In Japanese).

23. 

Kimura M, Usami E, Okada K, Nakao T, Yoshimura T and Yasuda T: Safety evaluation for chemotherapy with S-1 and cisplatin based on nutrition factors using body mass index and serum albumin levels in patients with advanced and recurrent gastric cancer. J Jpn Soc Hosp Pharm. 45:785–788. 2009.(In Japanese).

24. 

Kimura M, Morihata K, Ito D, Iwai M, Okada K, Usami E, Nakao T, Yoshimura T and Yasuda T: Continuous administration and safety of S-1 in adjuvant chemotherapy for gastric cancer. Jpn J Canc Chemother. 37:829–834. 2010.(In Japanese).

25. 

Ueda S, Hironaka S, Yasui H, et al: Randomized phase III study of irinotecan (CPT-11) versus weekly paclitaxel (wPTX) for advanced gastric cancer (AGC) refractory to combination chemotherapy (CT) of fluoropyrimidine plus platinum (FP): WJOG4007 trial. J Clin Oncol. 30:(American Society of Clinical Oncology, 48th Annual Meeting): abs. 4002. 2012.

26. 

Shitara K, Matsuo K, Takahari D, et al: Neutropenia as a prognostic factor in advanced gastric cancer patients undergoing second-line chemotherapy with weekly paclitaxel. Ann Oncol. 21:2403–2409. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kimura M, Usami E, Kanematsu T, Iwai M, Yoshimura T, Mori H, Sugiyama T and Teramachi H: Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer. Mol Clin Oncol 2: 466-472, 2014.
APA
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H. ... Teramachi, H. (2014). Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer. Molecular and Clinical Oncology, 2, 466-472. https://doi.org/10.3892/mco.2014.260
MLA
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H., Sugiyama, T., Teramachi, H."Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer". Molecular and Clinical Oncology 2.3 (2014): 466-472.
Chicago
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H., Sugiyama, T., Teramachi, H."Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer". Molecular and Clinical Oncology 2, no. 3 (2014): 466-472. https://doi.org/10.3892/mco.2014.260
Copy and paste a formatted citation
x
Spandidos Publications style
Kimura M, Usami E, Kanematsu T, Iwai M, Yoshimura T, Mori H, Sugiyama T and Teramachi H: Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer. Mol Clin Oncol 2: 466-472, 2014.
APA
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H. ... Teramachi, H. (2014). Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer. Molecular and Clinical Oncology, 2, 466-472. https://doi.org/10.3892/mco.2014.260
MLA
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H., Sugiyama, T., Teramachi, H."Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer". Molecular and Clinical Oncology 2.3 (2014): 466-472.
Chicago
Kimura, M., Usami, E., Kanematsu, T., Iwai, M., Yoshimura, T., Mori, H., Sugiyama, T., Teramachi, H."Safety and continuity of second‑ and third‑line therapy with paclitaxel or irinotecan for advanced and recurrent gastric cancer". Molecular and Clinical Oncology 2, no. 3 (2014): 466-472. https://doi.org/10.3892/mco.2014.260
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team