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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting

  • Authors:
    • Hiroki Ueda
    • Chigusa Shimono
    • Tomoyasu Nishimura
    • Megumi Shimamoto
    • Hiroki Yamaue
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Oncology Center, School of Medicine, Wakayama Medical University, Wakayama, Wakayama, Japan, Ambulatory Therapy Center, Wakayama Medical University, School of Medicine, Wakayama, Wakayama, Japan, Ambulatory Therapy Center, School of Medicine, Wakayama Medical University, Wakayama, Wakayama, Japan
  • Pages: 375-379
    |
    Published online on: February 20, 2014
       https://doi.org/10.3892/mco.2014.263
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Abstract

In order to ensure the continuity of chemotherapy, it is crucial to provide appropriate supportive care to prevent chemotherapy‑induced nausea and vomiting (CINV). The frequency of CINV is greatly affected by the type and combination of chemotherapy employed, which requires further investigation. With the use of patient diaries, a prospective study on the efficacy of antiemetic regimens for nausea and vomiting was conducted in 103 patients receiving highly or moderately emetogenic chemotherapy in the Ambulatory Therapy Center of our institution between August, 2010 and March, 2011. In this study, the efficacy of palonosetron in the delayed phase was affirmed. on days 4 and 5, in particular, palonosetron exhibited a significantly higher efficacy compared to that of other conventional serotonin (5‑HT3) receptor antagonists (5‑HT3RAs). When the effects of chemotherapy on food intake were assessed by switching granisetron to palonosetron, an improvement in appetite was observed in one‑quarter of the cases in the delayed phase. In addition, palonosetron has not been associated with any severe adverse drug reactions. It was therefore suggested that the use of palonosetron be recommended as a 5‑HT3RA. In conclusion, our data suggested that palonosetron is effective and may be used as a 5‑HT3RA, since it is crucial that we take adequate measures against CINV in order to maintain the patients' quality of life and to develop antiemetic regimens that ensure the continuity of chemotherapy without dose reduction.
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Copy and paste a formatted citation
Spandidos Publications style
Ueda H, Shimono C, Nishimura T, Shimamoto M and Yamaue H: Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting. Mol Clin Oncol 2: 375-379, 2014.
APA
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., & Yamaue, H. (2014). Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting. Molecular and Clinical Oncology, 2, 375-379. https://doi.org/10.3892/mco.2014.263
MLA
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., Yamaue, H."Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting". Molecular and Clinical Oncology 2.3 (2014): 375-379.
Chicago
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., Yamaue, H."Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting". Molecular and Clinical Oncology 2, no. 3 (2014): 375-379. https://doi.org/10.3892/mco.2014.263
Copy and paste a formatted citation
x
Spandidos Publications style
Ueda H, Shimono C, Nishimura T, Shimamoto M and Yamaue H: Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting. Mol Clin Oncol 2: 375-379, 2014.
APA
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., & Yamaue, H. (2014). Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting. Molecular and Clinical Oncology, 2, 375-379. https://doi.org/10.3892/mco.2014.263
MLA
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., Yamaue, H."Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting". Molecular and Clinical Oncology 2.3 (2014): 375-379.
Chicago
Ueda, H., Shimono, C., Nishimura, T., Shimamoto, M., Yamaue, H."Palonosetron exhibits higher total control rate compared to first‑generation serotonin antagonists and improves appetite in delayed‑phase chemotherapy‑induced nausea and vomiting". Molecular and Clinical Oncology 2, no. 3 (2014): 375-379. https://doi.org/10.3892/mco.2014.263
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