Expression and clinical significance of girdin in gastric cancer

Wang,Caihua; Lin,Jie; Li,Lurong; Wang,Yun

doi:10.3892/mco.2014.265

May-June 2014 Volume 2 Issue 3

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May-June 2014 Volume 2 Issue 3

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Article

Expression and clinical significance of girdin in gastric cancer

Authors:
- Caihua Wang
- Jie Lin
- Lurong Li
- Yun Wang
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Guanghe Chinese and Western Medicine Hospital, Zhangjiagang, Jiangsu 215633, P.R. China, Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China
Pages: 425-428
|
Published online on: February 24, 2014

https://doi.org/10.3892/mco.2014.265
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Abstract

Gastric cancer is one of the most common malignant tumors and the second leading cause of cancer‑related mortality. Elucidating the molecular mechanism underlying the development of gastric cancer is crucial in identifying gastric cancer‑susceptible populations, screening for tumor markers and in the application of gene therapy. This study was conducted to investigate girdin expression in gastric cancer and para‑cancer tissues and to elucidate the role of girdin in the development of gastric cancer. Tissue microarray and streptavidin‑peroxidase immunohistochemical staining were used to detect girdin expression in 105 gastric cancer and 72 para‑cancer tissue samples. Analyses of the patients' clinical and pathological data were also performed. The expression ratio of girdin was 40.0% in gastric cancer and 11.1% in the para‑cancer tissues and the difference was statistically significant (P<0.05). Girdin expression was found to be positively correlated (P<0.05) with tumor invasion depth and lymph node metastasis, while no significant associations were found between girdin expression and gender, age, tumor size, pathological grade and clinical stage (P>0.05). In conclusion, the upregulation of girdin expression in gastric cancer may contribute to tumor metastasis and cancer development, suggesting that girdin may be a novel indicator for evaluating lymph node metastasis and gastric cancer outcome.

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1.	Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar
2.	Enomoto A, Murakami H, Asai N, et al: Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell. 9:389–402. 2005. View Article : Google Scholar : PubMed/NCBI
3.	Enomoto A, Ping J and Takahashi M: Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways. Ann NY Acad Sci. 1086:169–184. 2006. View Article : Google Scholar : PubMed/NCBI
4.	Weng L, Enomoto A, Ishida-Takagishi M, Asai N and Takahashi M: Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis. Cancer Sci. 101:836–842. 2010. View Article : Google Scholar : PubMed/NCBI
5.	Kitamura T, Asai N, Enomoto A, et al: Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol. 10:329–337. 2008. View Article : Google Scholar : PubMed/NCBI
6.	Enomoto A, Asai N, Namba T, et al: Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. Neuron. 63:774–787. 2009. View Article : Google Scholar : PubMed/NCBI
7.	Liu C, Zhang Y, Xu H, et al: Girdin protein: a new potential distant metastasis predictor of breast cancer. Med Oncol. 29:1554–1560. 2012. View Article : Google Scholar : PubMed/NCBI
8.	Ling Y, Jiang P, Cui SP, et al: Clinical implications for girdin protein expression in breast cancer. Cancer Invest. 29:405–410. 2011. View Article : Google Scholar : PubMed/NCBI
9.	Jun BY, Kim SW, Jung CK, et al: Expression of girdin in human colorectal cancer and its association with tumor progression. Dis Colon Rectum. 56:51–57. 2013. View Article : Google Scholar : PubMed/NCBI
10.	Forte GI, Calà C, Scola L, et al: Role of environmental and genetic factor interaction in age-related disease development: the gastric cancerparadigm. Rejuvenation Res. 11:509–512. 2008. View Article : Google Scholar : PubMed/NCBI
11.	Brivanlou AH and Darnell JE Jr: Signal transduction and the control of gene expression. Science. 295:813–818. 2002. View Article : Google Scholar : PubMed/NCBI
12.	Ghosh P, Garcia-Marcos M and Farquhar MG: GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr. 5:237–248. 2011. View Article : Google Scholar : PubMed/NCBI
13.	Jiang P, Enomoto A, Jijiwa M, et al: An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 68:1310–1318. 2008. View Article : Google Scholar : PubMed/NCBI
14.	Ghosh P, Garcia-Marcos M, Bornheimer SJ and Farquhar MG: Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 182:381–393. 2008. View Article : Google Scholar : PubMed/NCBI
15.	Zhang B, Gu F, She C, et al: Reduction of Akt2 inhibits migration and invasion of glioma cells. Int J Cancer. 125:585–595. 2009. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression and clinical significance of girdin in gastric cancer

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Abstract

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