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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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July-August 2014 Volume 2 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors

  • Authors:
    • Qi Niu
    • Wei Wang
    • Qian Li
    • Yong Li
    • Douglas M. Ruden
    • Fenghua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, 309 PLA Hospital, Haidian, Beijing 100091, P.R. China, Department of Internal Medicine, Beijing Language and Culture University Hospital, Haidian, Beijing 100083, P.R. China, Department of Obstetrics and Gynecology, Institute of Environmental Health Sciences, C.S. Mott Center for Human Health and Development, Wayne State University, Detroit, MI 48201, USA, Department of Pathology, 309 PLA Hospital, Haidian, Beijing 100091, P.R. China
  • Pages: 491-496
    |
    Published online on: April 14, 2014
       https://doi.org/10.3892/mco.2014.275
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Abstract

Cisplatin [cis‑diammineplatinum dichloride (DDP)] resistance is a major limitation in the treatment of lung cancer. We previously demonstrated that DDP dissolved in 5% ethanol (5% ethanol‑DDP) injected intratumorally was able to eradicate DDP‑resistant lung tumors and prolong survival, as 5% ethanol improved DDP delivery to the tumor. The present study aimed to investigate the efficacy of DDP in various concentrations of ethanol and determine the optimal ethanol concentration in which DDP exhibits optimal efficacy in reducing tumor volume and prolonging survival. The efficiency of DDP dissolved in 2, 5, 10, 20 and 50% ethanol (v̸v) in DDP‑resistant A549̸DDP lung tumor‑bearing Balb̸C nude mice was investigated. Tumor growth and survival were evaluated in all the treatment groups. Microvessel density in xenograft tumor tissues was measured by immunohistochemistry. Our results revealed that 5% ethanol‑DDP exhibited the highest efficiency in reducing tumor volume and prolonging survival among all the investigated ethanol‑DDP combinations. We found that 5% ethanol‑DDP produced the most significant inhibition of tumor angiogenesis among all the remaining ethanol‑DDP combinations, while treatment with ethanol alone increased tumor angiogenesis. In conclusion, 5% ethanol‑DDP produced the strongest tumor growth inhibition and longest survival among all the investigated ethanol‑DDP combinations, possibly providing a novel therapeutic strategy for improving the survival of patients with DDP‑resistant lung cancer. The potent inhibition of tumor angiogenesis by 5% ethanol‑DDP may be one of the mechanisms underlying its superior efficiency.
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Copy and paste a formatted citation
Spandidos Publications style
Niu Q, Wang W, Li Q, Li Y, Ruden DM and Wang F: Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors. Mol Clin Oncol 2: 491-496, 2014.
APA
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D.M., & Wang, F. (2014). Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors. Molecular and Clinical Oncology, 2, 491-496. https://doi.org/10.3892/mco.2014.275
MLA
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D. M., Wang, F."Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors". Molecular and Clinical Oncology 2.4 (2014): 491-496.
Chicago
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D. M., Wang, F."Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors". Molecular and Clinical Oncology 2, no. 4 (2014): 491-496. https://doi.org/10.3892/mco.2014.275
Copy and paste a formatted citation
x
Spandidos Publications style
Niu Q, Wang W, Li Q, Li Y, Ruden DM and Wang F: Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors. Mol Clin Oncol 2: 491-496, 2014.
APA
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D.M., & Wang, F. (2014). Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors. Molecular and Clinical Oncology, 2, 491-496. https://doi.org/10.3892/mco.2014.275
MLA
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D. M., Wang, F."Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors". Molecular and Clinical Oncology 2.4 (2014): 491-496.
Chicago
Niu, Q., Wang, W., Li, Q., Li, Y., Ruden, D. M., Wang, F."Intratumoral injection of cisplatin in various concentrations of ethanol for cisplatin‑resistant lung tumors". Molecular and Clinical Oncology 2, no. 4 (2014): 491-496. https://doi.org/10.3892/mco.2014.275
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