Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2014 Volume 2 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma

  • Authors:
    • Isabella Wai Yin Cheuk
    • Shea Ping Yip
    • Dora Lai Wan Kwong
    • Vincent Wing Cheung Wu
  • View Affiliations / Copyright

    Affiliations: Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, SAR, P.R. China, Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam, Hong Kong, SAR, P.R. China
  • Pages: 553-558
    |
    Published online on: April 14, 2014
       https://doi.org/10.3892/mco.2014.276
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Radiation‑induced fibrosis is one of the late complications of radiotherapy (RT) for nasopharyngeal carcinoma (NPC). The aim of this study was to investigate the association between X-ray repair cross-complementing protein 1 and 3 (XRCC1 and XRCC3, respectively) gene haplotypes and radiation‑induced fibrosis in NPC patients. Genomic DNA was extracted from blood samples of 120 NPC patients previously treated with RT. In total, 12 tag single‑nucleotide polymorphisms (SNPs) were selected from the XRCC1 and XRCC3 genes and were genotyped using restriction fragment length polymorphism analysis or unlabeled probe melting analysis. Single‑marker and haplotype analyses were performed using multivariate logistic regression analysis. The functional variant rs861539 of XRCC3 may be associated with radiation‑induced fibrosis [asymptotic P‑value (Pasym)<0.05]. No significant association was observed between radiation‑induced fibrosis and any of the tag SNPs of XRCC1 and XRCC3 in either single‑marker or haplotype analysis after 10,000 permutations [empirical P‑value (Pemp)>0.05]. Our preliminary results indicated that the rs861539 variant of XRCC3 may be associated with an increased risk of radiation‑induced fibrosis; however, a large‑scale study is required to confirm this result.
View Figures

Figure 1

Figure 2

View References

1 

Wei WI and Sham JS: Nasopharyngeal carcinoma. Lancet. 365:2041–2054. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Kam MK, Teo PM, Chau RM, et al: Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience. Int J Radiat Oncol Biol Phys. 60:1440–1450. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Lee AW, Law SC, Ng SH, et al: Retrospective analysis of nasopharyngeal carcinoma treated during 1976–1985 late complications following megavoltage irradiation. Br J Radiol. 65:918–928. 1992.

4 

Alsbeih G, Al-Harbi N, Al-Hadyan K, El-Sebaie M and Al-Rajhi N: Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes. Radiat Res. 173:505–511. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Alsbeih GA, El-Sebaie MM, Al-Rajhi NM, et al: Association between XRCC1 G399A polymorphism and late complications to radiotherapy in Saudi head and neck cancer patients. J Egypt Natl Canc Inst. 20:302–308. 2008.PubMed/NCBI

6 

Andreassen CN, Alsner J, Overgaard J, et al: TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Radiother Oncol. 75:18–21. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Andreassen CN, Alsner J, Overgaard M and Overgaard J: Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes. Radiother Oncol. 69:127–135. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Azria D, Ozsahin M, Kramar A, et al: Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. Clin Cancer Res. 14:6284–6288. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Brem R, Cox DG, Chapot B, et al: The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage. Carcinogenesis. 27:2469–2474. 2006.

10 

Burri RJ, Stock RG, Cesaretti JA, et al: Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. Radiat Res. 170:49–59. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Damaraju S, Murray D, Dufour J, et al: Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Clin Cancer Res. 12:2545–2554. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Giotopoulos G, Symonds RP, Foweraker K, et al: The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes. Br J Cancer. 96:1001–1007. 2007. View Article : Google Scholar

13 

Moullan N, Cox DG, Angèle S, Romestaing P, Gerard JP and Hall J: Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev. 12:1168–1174. 2003.PubMed/NCBI

14 

Suga T, Iwakawa M, Tsuji H, et al: Influence of multiple genetic polymorphisms on genitourinary morbidity after carbon ion radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 72:808–813. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Zschenker O, Raabe A, Boeckelmann IK, et al: Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol. 97:26–32. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Chang-Claude J, Ambrosone CB, Lilla C, et al: Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Br J Cancer. 100:1680–1686. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Popanda O, Marquardt JU, Chang-Claude J and Schmezer P: Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res. 667:58–69. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Alsbeih G, El-Sebaie M, Al-Harbi N, Al-Hadyan K, Shoukri M and Al-Rajhi N: SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers. Radiat Oncol. 8:1252013. View Article : Google Scholar : PubMed/NCBI

19 

de Bakker PI, Yelensky R, Pe’er I, Gabriel SB, Daly MJ and Altshuler D: Efficiency and power in genetic association studies. Nat Genet. 37:1217–1223. 2005.PubMed/NCBI

20 

International HapMap Consortium. The International HapMap Project. Nature. 426:789–796. 2003. View Article : Google Scholar

21 

Purcell S, Neale B, Todd-Brown K, et al: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 81:pp. 559–575. 2007, http://pngu.mgh.harvard.edu/~purcell/plink. Accessed, July 19, 2013

22 

Schwarzer G: Meta: An R package for meta-analysis. R News. 7:pp. 40–45. 2007, http://cran.r-project.org/web/packages/meta/index.html. Accessed, September 8, 2013

23 

Higgins JPT and Green S: Cochrane Handbook for Systematic Reviews of Interventions, version 5.10. The Cochrane Collaboration; 2011, http://handbook.cochrane.org. Accessed July 27, 2013

24 

Bentzen SM: Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer. 6:702–713. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Andreassen CN and Alsner J: Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. Radiother Oncol. 92:299–309. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Barnett GC, Coles CE, Elliott RM, et al: Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study. Lancet Oncol. 13:65–77. 2012. View Article : Google Scholar : PubMed/NCBI

27 

West CM, Dunning AM and Rosenstein BS: Genome-wide association studies and prediction of normal tissue toxicity. Semin Radiat Oncol. 22:91–99. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Talbot CJ, Tanteles GA, Barnett GC, et al: A replicated association between polymorphisms near TNFα and risk for adverse reactions to radiotherapy. Br J Cancer. 107:748–753. 2012.PubMed/NCBI

29 

Kerns SL, Ostrer H, Stock R, et al: Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 78:1292–1300. 2010. View Article : Google Scholar

30 

Lorimore SA, Coates PJ and Wright EG: Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene. 22:7058–7069. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Barnett GC, West CM, Coles CE, et al: Standardized total average toxicity score: a scale- and grade-independent measure of late radiotherapy toxicity to facilitate pooling of data from different studies. Int J Radiat Oncol Biol Phys. 82:1065–1074. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheuk IW, Yip SP, Kwong DL and Wu VW: Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma. Mol Clin Oncol 2: 553-558, 2014.
APA
Cheuk, I.W., Yip, S.P., Kwong, D.L., & Wu, V.W. (2014). Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma. Molecular and Clinical Oncology, 2, 553-558. https://doi.org/10.3892/mco.2014.276
MLA
Cheuk, I. W., Yip, S. P., Kwong, D. L., Wu, V. W."Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma". Molecular and Clinical Oncology 2.4 (2014): 553-558.
Chicago
Cheuk, I. W., Yip, S. P., Kwong, D. L., Wu, V. W."Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 553-558. https://doi.org/10.3892/mco.2014.276
Copy and paste a formatted citation
x
Spandidos Publications style
Cheuk IW, Yip SP, Kwong DL and Wu VW: Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma. Mol Clin Oncol 2: 553-558, 2014.
APA
Cheuk, I.W., Yip, S.P., Kwong, D.L., & Wu, V.W. (2014). Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma. Molecular and Clinical Oncology, 2, 553-558. https://doi.org/10.3892/mco.2014.276
MLA
Cheuk, I. W., Yip, S. P., Kwong, D. L., Wu, V. W."Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma". Molecular and Clinical Oncology 2.4 (2014): 553-558.
Chicago
Cheuk, I. W., Yip, S. P., Kwong, D. L., Wu, V. W."Association of XRCC1 and XRCC3 gene haplotypes with the development of radiation‑induced fibrosis in patients with nasopharyngeal carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 553-558. https://doi.org/10.3892/mco.2014.276
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team