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July-August 2014 Volume 2 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy

  • Authors:
    • Ahmed Ibrahim
    • Mohamed Sobeh
    • Aya Ismail
    • Ahmed Alaa
    • Hussein Sheashaa
    • Mohamed Sobh
    • Farid Badria
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt, Medical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt, Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
  • Pages: 581-585
    |
    Published online on: April 16, 2014
       https://doi.org/10.3892/mco.2014.278
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Abstract

Although flavonoids have been identified as a versatile source of anticancer agents, to the best of our knowledge, no study has yet investigated their anticolon cancer activity in depth. Therefore, the aim of this study was to investigate the association between the structural characteristics of flavonoids and their anticolon cancer activity in the Caco‑2 human colon cancer cell line. Our findings demonstrated that the hydroxylation of C5 and C7 in ring A significantly enhanced the anticolon cancer activity of flavonoids over that of 5‑fluorouracil, the classic reference cytotoxic agent. By contrast, the glycosylation or the presence of hydroxyl groups in ring B significantly decreased flavonoid anticancer activity. Collectively, these findings suggest a novel, rational design of flavonoid‑related compounds that may improve the treatment of colorectal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Ibrahim A, Sobeh M, Ismail A, Alaa A, Sheashaa H, Sobh M and Badria F: Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy. Mol Clin Oncol 2: 581-585, 2014.
APA
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., & Badria, F. (2014). Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy. Molecular and Clinical Oncology, 2, 581-585. https://doi.org/10.3892/mco.2014.278
MLA
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., Badria, F."Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy". Molecular and Clinical Oncology 2.4 (2014): 581-585.
Chicago
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., Badria, F."Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy". Molecular and Clinical Oncology 2, no. 4 (2014): 581-585. https://doi.org/10.3892/mco.2014.278
Copy and paste a formatted citation
x
Spandidos Publications style
Ibrahim A, Sobeh M, Ismail A, Alaa A, Sheashaa H, Sobh M and Badria F: Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy. Mol Clin Oncol 2: 581-585, 2014.
APA
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., & Badria, F. (2014). Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy. Molecular and Clinical Oncology, 2, 581-585. https://doi.org/10.3892/mco.2014.278
MLA
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., Badria, F."Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy". Molecular and Clinical Oncology 2.4 (2014): 581-585.
Chicago
Ibrahim, A., Sobeh, M., Ismail, A., Alaa, A., Sheashaa, H., Sobh, M., Badria, F."Free‑B‑Ring flavonoids as potential lead compounds for colon cancer therapy". Molecular and Clinical Oncology 2, no. 4 (2014): 581-585. https://doi.org/10.3892/mco.2014.278
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